Formula: C15H16O《Accelerated SuFEx Click Chemistry For Modular Synthesis》 was published in 2022. The authors were Smedley, Christopher J.;Homer, Joshua A.;Gialelis, Timothy L.;Barrow, Andrew S.;Koelln, Rebecca A.;Moses, John E., and the article was included in《Angewandte Chemie, International Edition》. The author mentioned the following in the article:
The development of accelerated SuFEx click chem. (ASCC), an improved SuFEx method for the efficient and catalytic coupling of aryl and alkyl alcs. with a range of SuFExable hubs was reported. Barton’s hindered guanidine base (2-tert-butyl-1,1,3,3-tetramethylguanidine; BTMG) was demonstrated as a superb SuFEx catalyst, when used in synergy with silicon additive hexamethyldisilazane (HMDS), yielded stable S-O bond linkages in a single step; often within minutes. The powerful combination of BTMG and HMDS reagents allowed for catalyst loadings as low as 1.0 mol % and in congruence with click-principles, provided a scalable method that is safe, efficient and practical for modular synthesis. ASSC expands the number of accessible SuFEx products and will find significant application in organic synthesis, medicinal chem., chem. biol., and materials science. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.
4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts