Ansari, Arshad J.; Yadav, Ayushi; Mukherjee, Anirban; Sathish, Elagandhula; Nagesh, Kommu; Singh, Ritesh published the artcile< Metal free amination of congested and functionalized alkyl bromides at room temperature>, SDS of cas: 5344-90-1, the main research area is aryl amine preparation; bromoamide aromatic heteroaromatic amine amination; benzodiazepine preparation.
The authors report a highly facile and unprecedented approach to synthesize congested N-(hetero)aryl amines, e.g., 4-NCC6H4NNHCMe2CONHOBn, en route to α-amino acid amides using α-bromoamides as alkylating agents under mild reaction conditions (room temperature). The involvement of aza-oxyallyl cations as alkylating agents is the hallmark of this reaction. This method was readily adapted for the rapid synthesis of coveted 1,4-benzodiazepine-3,5-diones I [R = R1 = H, MeO, R2 = OBn; R = R1 = R2 = H; R = R1 = MeO, R2 = H; R = H, R1 = Cl, R2 = OBn].
Chemical Communications (Cambridge, United Kingdom) published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, SDS of cas: 5344-90-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts