Month: September 2022

Yamashita, Junko;Hirata, Yukio published 《Running fits and γ-aminobutyric acid of the superior colliculus of the mouse》 in 1979. The article was appeared in 《Journal of Nutritional Science and Vitaminology》. They have made some progress in their research.Electric Literature of C8H12ClNO2 The article mentions the following:

The γ-aminobutyric acid content of the superior colliculus of the mouse brain was decreased following the induction of running fits by the intracollicular injection of the antivitamin B₆ compound semicarbazide. Aminooxyacetic acid hemihydrochloride, an inhibitor of 4-aminobutyrate-2-oxoglutarate aminotransferase (EC 2.6.1.19) with a resultant increase in GABA levels, has been shown to exert an antidotal effect on the induction of running fits. Therefore, this type of convulsive behavior is apparently associated with diminished levels of GABA in the superior colliculus. Running fits were also induced by the antivitamin B₆ compounds thiosemicarbazide and 4-deoxypyridoxine-HCl, and presumedly this was also the result of a decrease in GABA level. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Electric Literature of C8H12ClNO2) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Reference:
Alcohol – Wikipedia,
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Schmode, Philip;Hochgesang, Adrian;Goel, Mahima;Meichsner, Florian;Mohanraj, John;Fried, Martina;Thelakkat, Mukundan published 《A Solution-Processable Pristine PEDOT Exhibiting Excellent Conductivity, Charge Carrier Mobility, and Thermal Stability in the Doped State》 in 2021. The article was appeared in 《Macromolecular Chemistry and Physics》. They have made some progress in their research.COA of Formula: C16H34O The article mentions the following:

PEDOT:PSS [poly(3,4-ethylenedioxythiophene) polystyrene sulfonate] is a widely used insoluble conducting polymer, which is therefore processed from dispersions. In this work, PEDOT homopolymers (PEDOT-C₆C₈ 1 and 2) highly soluble in common solvents like toluene, THF, and chloroform are synthesized with a high control of mol. weight and low dispersity using Kumada catalyst transfer polymerization of a newly synthesized EDOT monomer carrying a branched alkyl substituent. Pristine PEDOT-C₆C₈ allows the use in accumulation mode transistors with a high charge carrier mobility of 5 x 10^-4 cm² V^-1 s^-1. Moreover, these polymers can be doped in a controlled fashion, reaching conductivities of 10^-3 S cm^-1 at 10 mol% of a dopant, Spiro-MeOTAD(TFSI)₂. The doped state is remarkably stable, retaining 80% of the initial value after annealing under nitrogen at 100 °C and being exposed to ambient atm. for up to 12 h. During doping, the hole injection barrier decreases and reaches an impressively low value of 130 meV at only 2.5 mol% dopant loading without loss in carrier mobility; as monitored using UV photoelectron- and impedance spectroscopy. This new design concept leading to highly soluble polymers with well-controlled mol. weights provides solution-processable PEDOT dopable in a well-controlled fashion. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.COA of Formula: C16H34O This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Alcohol – Wikipedia,
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HPLC of Formula: 78-69-3In 2021, Murad, Ary R.;Iraqi, Ahmed;Aziz, Shujahadeen B.;Abdullah, Sozan N.;Brza, Mohamad A.;Saeed, Salah R.;Abdulwahid, Rebar T. published 《Fabrication of alternating copolymers based on cyclopentadithiophene-benzothiadiazole dicarboxylic imide with reduced optical band gap: synthesis, optical, electrochemical, thermal, and structural properties》. 《Polymers (Basel, Switzerland)》published the findings. The article contains the following contents:

A series of alternating copolymers containing cyclopentadithiophene (CPDT) flanked by thienyl moieties as electron-donor units and benzothiadiazole dicarboxylic imide (BTDI) as electron-acceptor units were designed and synthesized for solar cell applications. Different solubilizing side chains, including 2-ethylhexyl chains and n-octyl chains were attached to CPDT units, whereas 3,7-dimethyloctyl chains and n-octyl chains were anchored to the BTDI moieties. The impact of these substituents on the solubilities, mol. weights, optical and electrochem. properties, and thermal and structural properties of the resulting polymers was investigated. PCPDTDTBTDI-EH, DMO was synthesized via Suzuki polymerization, whereas PCPDTDTBTDI-8, DMO, and PCPDTDTBTDI-EH, 8 were prepared through direct arylation polymerization PCPDTDTBTDI-8, DMO has the highest number average mol. weight (M_n = 17,400 g mol-1) among all polymers prepared The PCPDTDTBTDI-8, DMO and PCPDTDTBTDI-8, 8 which have n-octyl substituents on their CPDT units have comparable optical band gaps (E_g ∼ 1.3 eV), which are around 0.1 eV lower than PCPDTDTBTDI-EH, DMO analogs that have 2-ethylhexyl substituents on their CPDT units. The polymers have their HOMO levels between -5.10 and -5.22 eV with PCPDTDTBTDI-EH, DMO having the deepest HOMO (HOMO) energy level. The LUMO (LUMO) levels of the polymers are between -3.4 and -3.5 eV. All polymers exhibit good thermal stability with decomposition temperatures surpassing 350 °C. Powder X-ray diffraction (XRD) studies have shown that all polymers have the amorphous nature in solid state. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Grand, Caroline;Cogen, Jeffrey M.;Wills, Scott T. published 《Stability of phenolic antioxidants in the presence of sulfonic acid: model compound studies for moisture-crosslinked polyethylene》. The research results were published in《Polymer Degradation and Stability》 in 2021.Formula: C23H32O2 The article conveys some information:

Alkoxysilane-functionalized polyethylene can be crosslinked in the presence of acid catalysts, including Bronsted acids, to yield durable pipe and cable insulation materials. To provide guidelines for the selection of stable phenolic antioxidants in the presence of Bronsted acids, reactions of 4 model alkylphenol compounds in the presence of p-dodecylbenzenesulfonic acid (DBSA) in dodecane were studied as a solution model for polyethylene-based systems. The results point to increasing stability towards DBSA of phenolic compounds when: (i) alkyl groups have less substitution (tertiary carbon compared to quaternary carbon), (ii) they have alkyl-substitution in the para position, and (iii) they have a reduced number of alkyl substituents around the phenol ring. Antioxidants with alkyl or isocyanurate bridges had reaction rates comparable to butylated hydroxytoluene (BHT) and followed the trend outlined in model alkylphenols. The sulfur-bridged antioxidant stood out as rapidly consumed under the reaction conditions. Therefore, selection of phenolic antioxidants for formulations containing strong Bronsted acids should generally favor phenolic compounds with alkyl-substituted para positions and limited number of alkyl substituents in non-para positions, and without quaternary carbon substituents. Moreover, stability of alternate sulfur-containing antioxidants should be assessed if used with sulfonic acids, given the rapid decomposition of the sulfur-bridged antioxidant observed in this work. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
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Formula: C23H32O2《Comparative analysis of volatile profiles in four pine-mushrooms using HS-SPME/GC-MS and E-nose》 was published in 2022. The authors were Guo, Qiyong;Adelina, Nadya Mara;Hu, Jintao;Zhang, Ligang;Zhao, Yuhong, and the article was included in《Food Control》. The author mentioned the following in the article:

Pine-mushrooms is rich in bioactive compounds, possess a unique aroma profile for culinary art. In China, pine-mushroom has been produced in Southwest and Northeast area. However, the discrepancy of volatile profiles in pine-mushrooms from two regions was unclear due to different extraction and detection method applied in research. This study attempted to compare the volatile profiles of four pine-mushrooms from Southwest (LS) and Northeast (HEB, SY, MDJ) using Headspace Solid Phase Microextraction coupled with Gas Chromatog. Mass Spectrometry (HS-SPME/GC-MS) and Electronic nose (E-nose). showed a significant difference in aroma profiles among samples. A total of 100 volatile compounds were identified, and separated into 11 classes. Benzaldehyde and hexanal were detected in all samples, which could be the pivotal aroma components in pine-mushrooms. Aromatic components, were present in LS pine-mushroom from Southwest China, including abundant of Me (Z)-N-hydroxybenzenecarboximidate, benzaldehyde, and Me 3-phenylprop-2-enoate. Meanwhile, some alcs. (such as oct-1-en-3-ol, hexan-1-ol) were characteristic compounds present in HEB, SY and MDJ samples. Principal component anal. (PCA) of E-nose data showed a clear distinction among samples. In addition, this study also highlighted the correlation between key volatile compounds detected by GC-MS and E-nose sensors, which could be benefit for further explanation to the origin of differences in sensory quality of pine-mushrooms. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
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Reference of (S)-2-Amino-2-(4-fluorophenyl)ethanol《Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols》 was published in 2020. The authors were Zhang, Jiandong;Yang, Xiaoxiao;Dong, Rui;Gao, Lili;Li, Jing;Li, Xing;Huang, Shuangping;Zhang, Chaofeng;Chang, Honghong, and the article was included in《ACS Sustainable Chemistry & Engineering》. The author mentioned the following in the article:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. To complete the study, the researchers used (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Reference of (S)-2-Amino-2-(4-fluorophenyl)ethanol

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Alcohol – Wikipedia,
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HPLC of Formula: 78-69-3《Thiol-yne Click Post-Modification for the Synthesis of Chiral Microporous Organic Networks for Chiral Gas Chromatography》 was published in 2020. The authors were Cui, Yuan-Yuan;Yang, Cheng-Xiong;Yan, Xiu-Ping, and the article was included in《ACS Applied Materials & Interfaces》. The author mentioned the following in the article:

Microporous organic networks (MONs) have shown great potential in diverse domains recently. However, the application of MONs in chiral separation or catalysis has been largely lagged due to the lack of chiral MONs and the challenge to synthesize chiral MONs. Here we report a facile thiol-yne click strategy to post-synthesize chiral MONs for the first application in chiral gas chromatog. Three chiral MONs with different chiral centers were rationally designed and synthesized to fabricate their capillary columns for gas chromatog. resolution of various chiral compounds with better resolution than three com. chiral capillary columns. These results show the great potential of the thiol-yne click strategy for constructing newly chiral MONs and their application in chiral separation And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocks《Effect of Position and Structure of the Terminal Moieties in the Side Group on the Liquid Crystal Alignment Behavior of Polystyrene Derivatives》 was published in 2021. The authors were Yang, DaEun;Seo, Kyutae;Kang, Hyo, and the article was included in《Polymers (Basel, Switzerland)》. The author mentioned the following in the article:

We synthesized a series of polystyrene derivatives containing various side groups, such as the 4-(tert-butyl)-phenoxymethyl, 3-(tert-butyl)-phenoxymethyl, 2-(tert-butyl)-phenoxymethyl, 4-cumyl-phenoxymethyl, and 4-trityl-phenoxymethyl groups, through a polymer modification reaction to examine the liquid crystal (LC) alignment of these derivatives In general, the vertical LC alignment on polymer films can be affected by the position and structure of the terminal moiety of the polymer side group. For example, the LC cells fabricated with 4-(tert-butyl)-phenoxymethyl-substituted polystyrene having a tert-Bu moiety as a para-type attachment to the phenoxy groups of the polystyrene derivatives exhibited vertical LC alignment, whereas the LC cells prepared from 3-(tert-butyl)- and 2-(tert-butyl)-phenoxymethyl-substituted polystyrene films exhibited planar LC alignment. In addition, the LC cells fabricated from 4-cumyl- and 4-trityl-phenoxymethyl-substituted polystyrene films with addnl. Ph rings in the side groups exhibited planar LC alignment, in contrast to the LC alignment of the (tert-butyl)-phenoxymethyl-substituted polystyrene series. The vertical LC orientation was well correlated with the surface energy of these polymer films. For example, vertical LC orientation, which mainly originates due to the nonpolar tertiary carbon moiety having bulky groups, was observed when the surface energy of the polymer was lower than 36.6 mJ/m². To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Category: alcohols-buliding-blocks 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Umeyama, Tomokazu;Igarashi, Kensho;Sasada, Daiki;Ishida, Keiichi;Koganezawa, Tomoyuki;Ohtani, Shunsuke;Tanaka, Kazuo;Imahori, Hiroshi published 《Efficient Exciton Diffusion in Micrometer-Sized Domains of Nanographene-Based Nonfullerene Acceptors with Long Exciton Lifetimes in Blend Films with Conjugated Polymer》 in 2020. The article was appeared in 《ACS Applied Materials & Interfaces》. They have made some progress in their research.HPLC of Formula: 2425-77-6 The article mentions the following:

Phase-separated structures in photoactive layers composed of electron donors and acceptors in organic photovoltaics (OPVs) generally exert a profound impact on the device performance. Nonfullerene acceptors (NFAs) where a heteronanographene central core was furnished with branched alkoxy chains of different lengths, TACIC-EH, TACIC-BO, and TACIC-HD, were prepared to adjust the aggregation tendency and systematically probe the relations of film structures with photophys. and photovoltaic properties. The side-chain length showed negligible effects on the absorption properties and energy levels of TACICs. Regardless of the chain length, all TACIC films exhibited characteristically long singlet exciton lifetimes (1330-2330 ps) compared to those in solution (≤220 ps). Using a conjugated polymer donor, PBDB-T, the best OPV performance was achieved with TACIC-BO that contained medium-length chains, exhibiting a power conversion efficiency (PCE) of 9.92%. TACIC-HD with the longest chains showed deteriorated electron mobility due to the long insulating alkoxy groups. The PBDB-T:TACIC-HD-based device revealed a low charge collection efficiency and PCE (8.21%) relative to the PBDB-T:TACIC-BO-based device, but their film morphols. were analogous. TACIC-EH with the shortest chains showed low solubility and formed μm-sized large aggregates in the blend film with PBDB-T. Although the charge collection efficiency of PBDB-T:TACIC-EH was lower than that of PBDB-T:TACIC-BO, the efficiencies of exciton diffusion to the donor-acceptor interface were sufficiently high (>98%) owing to the elongated singlet exciton lifetime of TACIC-EH. The PCE of the PBDB-T:TACIC-EH-based device remained moderate (7.10%). Therefore, TACICs with the long singlet exciton lifetimes in the films provide a clear guideline for NFAs with low sensitivity of OPV device performance to the blend film structures, which is advantageous for large-scale OPV production with high reproducibility. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a branched alcohol. It is one of the constituent of the essential oil, extracted from the roots of Adiantum flabellulatum. HPLC of Formula: 2425-77-6

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Alcohol – Wikipedia,
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Wang, Hui;Shao, Hong-xia;Qin, Qiu-ming published 《Determination of 2,5-dimethyl-2,5-hexanediol in process components of voriconazole products for injection by UPLC-MS/MS》. The research results were published in《Zhejiang Huagong》 in 2021.Application In Synthesis of 2,5-Dimethyl-2,5-hexanediol The article conveys some information:

Objective: To establish an ultra high performance liquid phase-tandem mass spectrometry (UPLC-MS/MS) method for the determination of 2,5-dimethyl-2,5-hexanediol (DHD) in process components of voriconazole for injection. Methods: The sample was redissolved by water and added with internal standard 2-methylpentane-2,4-diol (MPD), extracted with acetonitrile and injected. The liquid mass spectrometer was used for anal. The mobile phase A was methanol, and mobile phase B was 0.1% ammonia solution Column ACQUITY UPLC BEH Ph (2.1 mm×50 mm, 1.7 μm) was used for separation Electrospray ionization source and multiple reaction monitoring (MRM) mode were used for neg. ion scanning detection. Results: DHD showed a good linearity within between 10.0-68.0 μg·L^-1 (r = 0.9990). The relative average deviation (RSD) of repeatability test was 1%, and the method recovery rate was 84-107%. The lower limit of detection (S/N ≈ 3) was 3.3 ppb, and the lower limit of quantification (S/N ≈ 10) was 10.0 ppb. The sample solution was stable in 24 h at room temperature Conclusion: UPLC-MS/MS method has many advantages, such as high sensitivity, accurate determination results, strong specificity and so on. UPLC-MS/MS method can be applied to the risk monitoring of DHD in process components of voriconazole for injection, and can provide a reference for the detection of DHD in other products. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Application In Synthesis of 2,5-Dimethyl-2,5-hexanediol

Reference:
Alcohol – Wikipedia,
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