Month: September 2022

Wang, Wanyi;Wang, Xin;Zhu, Qingqing;Zhou, Qunfang;Wang, Yawei;Liao, Chunyang;Jiang, Guibin published 《Occurrence of synthetic phenolic antioxidants in foodstuffs from ten provinces in China and its implications for human dietary exposure》. The research results were published in《Food and Chemical Toxicology》 in 2022.Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:

Synthetic phenolic antioxidants (SPAs) are widely used as food additives to delay the oxidation rate of oils and oil products. The concentrations and compositions of SPAs in Chinese residents most popular daily foods and the resulting exposure risk of SPAs are not clear. Therefore, this study collected food samples in 13 food categories (n = 289) from 10 provinces in China. At least one of the SPAs was detected in approx. 99.7% of foodstuffs, and the concentration of ∑SPAs ranged from not detected to 7830 (geometric mean (GM): 296 ng/g wet weight). 2,6-2 tert Bu p-1,4-benzoquinone (BHT-Q) was the main transformation product, but SPAs in food tend to exist in the parent form. A significant difference between food categories was analyzed. The highest GM of ΣSPAs occurred in cereals and cereal products, which was approx. 8 times higher than that in beverages. The estimated daily intakes of ΣSPAs in Chinese preschoolers, school-age children, adults and elderly individuals were 22200, 9970, 7540 and 7700 ng/kg bw/day, resp. The exposure risks of SPAs decreased with age. This is the first simultaneous anal. of SPAs in multiple provinces and multiple categories of foodstuffs. To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

Reference:
Alcohol – Wikipedia,
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Application In Synthesis of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol《ansa-Ruthenium(II) Complexes of R₂NSO₂DPEN-(CH₂)_n(η⁶-Aryl) Conjugate Ligands for Asymmetric Transfer Hydrogenation of Aryl Ketones》 was published in 2015. The authors were Kisic, Andrea;Stephan, Michel;Mohar, Barbara, and the article was included in《Advanced Synthesis & Catalysis》. The author mentioned the following in the article:

New 3rd generation designer ansa-ruthenium(II) complexes featuring N,C-alkylene-tethered N,N-dialkylsulfamoyl-DPEN/η⁶-arene ligands, exhibited good catalytic performance in the asym. transfer hydrogenation (ATH) of various classes of (het)aryl ketones in formic acid/triethylamine mixture In particular, benzo-fused cyclic ketones furnished 98 to >99.9% ee using a low catalyst loading. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Application In Synthesis of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

Reference:
Alcohol – Wikipedia,
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Recommanded Product: 78-69-3In 2019, Fu, Yu;Bak, Kathrine H.;Liu, Jing;De Gobba, Cristian;Toestesen, Marie;Hansen, Erik T.;Petersen, Mikael A.;Ruiz-Carrascal, Jorge;Bredie, Wender L. P.;Lametsch, Rene published 《Protein hydrolysates of porcine hemoglobin and blood: Peptide characteristics in relation to taste attributes and formation of volatile compounds》. 《Food Research International》published the findings. The article contains the following contents:

The objective of this study was to investigate the impact of endo- and exo-peptidase treatment on certain structural characteristics of peptides and volatile compounds of porcine Hb and whole blood hydrolyzates. Porcine Hb and whole blood were hydrolyzed by endo- and exo-peptidases. The presence of exopeptidases reduced the bitterness and altered the volatile profiles of protein hydrolyzates. Exopeptidase treatment can release terminal amino acids from peptides, which in turn may contribute to formation of volatile compounds by Maillard reactions. In contrast, endopeptidases conferred a slightly bitter taste and different volatile profiles. For Hb hydrolyzates, principal component anal. revealed that proteases were categorized into three groups based on endo- or exo-peptidase activity. Whole blood is a more complex raw material, yet the proteases were still categorized in a similar fashion. This work contributes to understanding structural characteristics responsible for taste and volatile profiles of protein hydrolyzates. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Bubmann, Tobias;Seidel, Andreas;Ruckdaeschel, Holger;Altstaedt, Volker published 《Transparent PC/PMMA Blends with Enhanced Mechanical Properties via Reactive Compounding of Functionalized Polymers》. The research results were published in《Polymers (Basel, Switzerland)》 in 2022.Safety of 4-(2-Phenylpropan-2-yl)phenol The article conveys some information:

Reactive compounding of terminally phenolic OH-functionalized polycarbonate (PC) with epoxy-functionalized polymethylmethacrylate (PMMA) prepared by copolymerization with glycidyl methacrylate was investigated. It was spectroscopically demonstrated that a PC/PMMA copolymer was formed during the melt reaction of the functional groups. Zirconium acetylacetonate could catalytically accelerate this reaction. Correlations of the phenomenol. (optical and mech.) properties with the mol. level and mesoscopic (morphol.) structure were discussed. By the investigated reactive compounding process, transparent PC/PMMA blends with two-phase morphologies were obtained in a continuous twin-screw extruder, which, for the first time, combined the high transmission of visible light with excellent mech. performance (e.g., synergistically improved tensile and flexural strength and high scratch resistance). The transparency strongly depended on (a) the degree of functionalization in both PC and PMMA, (b) the presence of the catalyst, and (c) the residence time of the compounding process. The in-situ-formed PC/PMMA copolymer influenced the observed macroscopic properties by (a) a decrease in the interphase tension, leading to improved and stabilized phase dispersion, (b) the formation of a continuous gradient of the polymer composition and thus of the optical refractive indexes in a diffuse mesoscopic interphase layer separating the PC and PMMA phases, and (c) an increase in the phase adhesion between PC and PMMA due to mech. polymer chain entanglement in this interphase. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Safety of 4-(2-Phenylpropan-2-yl)phenol 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kosower, Nechama S.;Rock, Rica A. published 《Seizures in experimental porphyria》. The research results were published in《Nature (London, United Kingdom)》 in 1968.Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride The article conveys some information:

Rats made porphyric by allylisopropylacetamide (I) are susceptible to induced convulsions. Female Sprague-Dawley rats (150-160 g.) were injected daily with 400 mg. I/kg. in 0.15M NaCl for 8-10 days. Controls received NaCl. Twenty-four hrs. after the last injection, control and exptl. animals were injected with isonicotinoylhydrazide (II) or 4-methoxymethylpyridoxol-HCl (III) at pH 7, or deoxypyridoxol-HCl (IV) at pH 7. Other animals were given pyridoxal-HCl (V) 15 min. prior to injection of the compounds At 0.75 millimoles II/kg., clonic-tonic convulsions occurred in 60% of porphyric rats and in none of the controls; at 1.12 millimoles/kg., 90% of the porphyric rats convulsed, and 20% of controls. At 0.5-2 millimoles/kg., V did not alter the convulsions induced by II. Following III at 0.25 millimoles/kg., 70% of porphyric rats convulsed, and all convulsed at 0.75 millimoles/kg. (but no controls convulsed). No difference was noted between controls and animals injected with IV. These compounds may act by interfering with pyridoxal 5-phosphate in the nervous system.5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) were involved in the experimental procedure.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Application In Synthesis of 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
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Electric Literature of C11H16O《Catalytic and enantioselective bromoetherification of olefinic 1,3-diols: mechanistic insight》 was published in 2016. The authors were Ke, Zhihai;Tan, Chong Kiat;Liu, Yi;Lee, Keefe Guang Zhi;Yeung, Ying-Yeung, and the article was included in《Tetrahedron》. The author mentioned the following in the article:

How can high enantioselectivity be achieved when the racemic background reaction proceeds at a rate comparable to that of the catalytic asym. reaction. We attempted to rationalize this counterintuitive observation by studying the effect of (1) catalyst structure, (2) temperature and addition sequence of components, (3) catalyst loading, and (4) Bronsted acid additives. In the course of our investigation, it was found that increasing the amount of catalyst used led to inhibition of the stoichiometric reaction. Olefinic 1,3-diol 1, 5 mol % of catalyst 3a, 1 equiv of MsOH, and NBS were added at low temperature in a specific sequence to provide the best performance for the enantioselective bromoetherification. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Electric Literature of C11H16O

Reference:
Alcohol – Wikipedia,
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Diler, Fatma;Burhan, Hakan;Genc, Hayriye;Kuyuldar, Esra;Zengin, Mustafa;Cellat, Kemal;Sen, Fatih published 《Efficient preparation and application of monodisperse palladium loaded graphene oxide as a reusable and effective heterogeneous catalyst for suzuki cross-coupling reaction》 in 2020. The article was appeared in 《Journal of Molecular Liquids》. They have made some progress in their research.Reference of 3,7-Dimethyloctan-3-ol The article mentions the following:

A homogeneously dispersed graphene oxide supported palladium nanomaterial (Pd@GO) has been successfully synthesized and used as a catalyst in cross-coupling reactions at room temperature Various anal. techniques such as X-ray Diffraction (XRD), XPS, transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM) were used to characterize the monodisperse Pd@GO. Monodisperse Pd@GO nanomaterials were used for the cross-coupling reactions which brought together organic mols. with functional significance. This catalyst showed superior catalytic activity and stability for these coupling reactions. High product yields, short reaction times and mild reaction conditions, obtained by the using of developed catalysts. Importantly, the catalyst can be used at least five experiments successfully without losing its efficiency. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Reference of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ling, Xiaoxi;Masson, Eric published 《Cucurbituril Slippage: Cations as Supramolecular Lubricants》 in 2012. The article was appeared in 《Organic Letters》. They have made some progress in their research.COA of Formula: C8H18O2 The article mentions the following:

The dethreading rate of a polyaminated axle flanked by two benzo-15-crown-5 stoppers from the cavity of Cucurbit[7]uril (CB[7]) was enhanced by up to 500 times in the presence of aqueous metallic and organic cations. Cations likely stabilize the highest energy transition state of the dethreading process by interacting with both crown ether and CB[7] units.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.COA of Formula: C8H18O2

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Qiu-yu;Zhang, Hai-feng;Zhu, Wen-zheng;Xue, Pan-pan;Sha, Wen-xuan;Su, Jia-min;Zhou, Xiao-yan published 《Effects of heating methods on quality and volatile substance contents of frozen red bean paste buns》 in 2021. The article was appeared in 《Xiandai Shipin Keji》. They have made some progress in their research.COA of Formula: C16H34O The article mentions the following:

The effects of heating methods on the quality and volatile substance contents of frozen red bean paste buns were examined Frozen red bean paste buns were heated using three methods, namely, steaming using a multifunction oven, steaming using a traditional food steamer, and microwave heating. Changes in quality parameters such as water content, texture, color, sp. volume, heating characteristics, and volatile flavor substance contents of the heated red bean paste buns were determined The results showed that heating methods had significant effects on the quality and relative contents of volatile flavor substances of frozen red bean paste buns (p<0.05). According to water content anal., microwave heating had the smallest effect in the proton migration rate. Texture anal. revealed that heating using a traditional food steamer yielded the least hard and chewy buns. L* values of the buns heated using microwave were the lowest whereas their a* values were the highest. The sp. volume of buns heated using a traditional food steamer was the largest, with the lowest water loss rate. In addition, buns heated using microwave had the highest pH values. Solid phase microextraction and gas chromatog.-mass spectrometry assays identified 52, 55, and 54 types of volatile flavor substances from buns heated using the three methods. The identified volatile flavor substances were mainly alcs., acids, esters, aldehydes, ketones, and phenols. The results further indicated that heating using a traditional food steamer was the most suitable method for frozen dough. These findings shall provide a theor. basis for the selection and control of heating methods for frozen dough.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.COA of Formula: C16H34O It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

Reference:
Alcohol – Wikipedia,
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Zhao, Fengqian;Ai, Han-Jun;Wu, Xiao-Feng published 《Radical Carbonylation under Low CO Pressure: Synthesis of Esters from Activated Alkylamines at Transition Metal-Free Conditions》 in 2021. The article was appeared in 《Chinese Journal of Chemistry》. They have made some progress in their research.Electric Literature of C15H16O The article mentions the following:

High CO pressure (> 40 bar) is usually needed in radical carbonylation reactions in the absence of metal catalyst. In this communication, a transition-metal-free radical carbonylation of activated alkylamines with phenols and alcs. under low CO pressure (1-6 bar) was developed. Various esters were obtained in moderate to excellent yields under simple reaction conditions with good functional group compatibility. The experimental procedure involved many compounds, such as 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Electric Literature of C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts