Month: September 2022

Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diolIn 2016, Archelas, Alain;Zhao, Wei;Faure, Bruno;Iacazio, Gilles;Kotik, Michael published 《Epoxide hydrolase-catalyzed enantioselective conversion of trans-stilbene oxide: Insights into the reaction mechanism from steady-state and pre-steady-state enzyme kinetics》. 《Archives of Biochemistry and Biophysics》published the findings. The article contains the following contents:

A detailed kinetic study based on steady-state and pre-steady-state measurements is described for the highly enantioselective epoxide hydrolase Kau2. The enzyme, which is a member of the α/β-hydrolase fold family, preferentially reacts with the (S,S)-enantiomer of trans-stilbene oxide (TSO) with an E value of ∼200. The enzyme follows a classical two-step catalytic mechanism with formation of an alkyl-enzyme intermediate in the first step and hydrolysis of this intermediate in a rate-limiting second step. Tryptophan fluorescence quenching during TSO conversion appears to correlate with alkylation of the enzyme. The steady-state data are consistent with (S,S) and (R,R)-TSO being two competing substrates with marked differences in k_cat and K_m values. The high enantiopreference of the epoxide hydrolase is best explained by pronounced differences in the second-order alkylation rate constant (k₂/K_S) and the alkyl-enzyme hydrolysis rate k₃ between the (S,S) and (R,R)-enantiomers of TSO. Our data suggest that during conversion of (S,S)-TSO the two active site tyrosines, Tyr¹⁵⁷ and Tyr²⁵⁹, serve mainly as electrophilic catalysts in the alkylation half-reaction, polarizing the oxirane oxygen of the bound epoxide through hydrogen bond formation, however, without fully donating their hydrogens to the forming alkyl-enzyme intermediate.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Name: rel-(1R,2S)-1,2-Diphenylethane-1,2-diol) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

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Zhu, Lihui;Li, Jiasheng;Yang, Jun;Au-Yeung, Ho Yu published 《Cross dehydrogenative C-O coupling catalysed by a catenane-coordinated copper(I)》. The research results were published in《Chemical Science》 in 2020.Formula: C15H16O The article conveys some information:

Catalytic activity of copper(I) complexes supported by phenanthroline-containing catenane ligands towards a new C(sp3)-O dehydrogenative cross-coupling of phenols ROH (R = Ph, 4-(2-phenylpropan-2-yl)phenyl, 2-formyl-4-methoxyphenyl, etc.) and bromodicarbonyls R¹C(O)CH(Br)C(O)R² (R¹ = Me, Ph, OBn, etc.; R² = OEt, OMe, OtBu, OBn) is reported. As the phenanthrolines are interlocked by the strong and flexible mech. bond in the catenane, the active catalyst with an open copper coordination site can be revealed only transiently and the stable, coordinatively saturated Cu(I) pre-catalyst is quickly regenerated after substrate transformation. Compared with a control Cu(I) complex supported by non-interlocked phenanthrolines, the catenane-supported Cu(I) is highly efficient with a broad substrate scope, and can be applied in gram-scale transformations without a significant loss of the catalytic activity. This work demonstrates the advantages of the catenane ligands that provide a dynamic and responsive copper coordination sphere, highlighting the potential of the mech. bond as a design element in transition metal catalyst development. To complete the study, the researchers used 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) .

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Formula: C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Adeleye, Temitope Adewumi;Ajiboye, Clement Odunayo;Ojah, Emmanuel Onah;Okesanjo, Toyin Patrick;Moronkola, Dorcas Olufunke published 《Composition and antioxidant potential of leaf and stem essential oils from Nigerian Indigofera spicata Forssk》. The research results were published in《Journal of Medicinal Plants Research》 in 2021.Synthetic Route of C16H34O The article conveys some information:

The chem. compositions and antioxidant evaluation of the essential oils (EOs) obtained by hydrodistillation from the leaf and stem of Indigofera spicata Forssk (Fabaceae) grown in Nigeria have been studied. The EOs were analyzed using gas chromatog. coupled with mass spectrometry (GC-MS) and the antioxidant potential was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging ability method. The essential oils from the leaf and stem obtained in 0.007% and 0.009% yield have been found to contain 18 and 17 compounds resp. 13 compounds identified in the stem EOs make 90.2% of it. Sesquiterpenes (49.2%) and alcs. (30.7%) are dominant classes of compounds in the leaf EOs, with the most abundant compounds as caryophyllene (38.2%), humulene (6.2%) and m-eugenol (27.5%). Whereas esters (47.2%), and monoterpenoids (20.8%) dominate the stem essential oils with major constituents as linalyl acetate (23.9%), α-terpinyl acetate (12.8%), 3,5,5-trimethyhexyl acetate (9.4%), and linalool (20.8%). Common to both EOs were linalool, (leaf, 1.9%) caryophyllene (stem 5.9%), linanyl acetate (leaf, 2.5%). Comparison of the composition pattern of the leaf and stem EOs of I. spicata revealed significant qual. and quant. differences. Monoterpenes, sesquiterpenoid, diterpenoid, epoxide and ether were exclusive to the leaf oil while saturated, unsaturated hydrocarbons and anhydride were found only in the stem oil. The IC₅₀ values of antioxidant evaluations show the leaf EO (36.97μg/mL) has more potential than the stem oil (39.89μg/mL) and comparable to that of the controls Vitamin C and Butylhydroxyl Anisole with IC₅₀ values 24.20 and 24.21μg/mL resp. Most of these identified compounds have been known for various pharmacol. activities such as antioxidant, antitumor, anti-inflammatory, even as fragrances and the antioxidant potential of the oils justify the ethno-medicinal uses of I. spicata. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Synthetic Route of C16H34O It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Yamada, Shoya;Kawasaki, Mayu;Fujihara, Michiko;Watanabe, Masaki;Takamura, Yuta;Takioku, Maho;Nishioka, Hiromi;Takeuchi, Yasuo;Makishima, Makoto;Motoyama, Tomoharu;Ito, Sohei;Tokiwa, Hiroaki;Nakano, Shogo;Kakuta, Hiroki published 《Competitive Binding Assay with an Umbelliferone-Based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening》 in 2019. The article was appeared in 《Journal of Medicinal Chemistry》. They have made some progress in their research.Recommanded Product: 2,5-Dimethyl-2,5-hexanediol The article mentions the following:

Ligands for retinoid X receptors (RXRs), “rexinoids”, are attracting interest as candidates for therapy of type 2 diabetes and Alzheimer’s and Parkinson’s diseases. However, current screening methods for rexinoids are slow and require special apparatus or facilities. Here, we created 7-hydroxy-2-oxo-6-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-2H-chromene-3-carboxylic acid (10, CU-6PMN) as a new fluorescent RXR agonist and developed a screening system of rexinoids using 10. Compound 10 was designed based on the fact that umbelliferone emits strong fluorescence in a hydrophilic environment, but the fluorescence intensity decreases in hydrophobic environments such as the interior of proteins. The developed assay using 10 enabled screening of rexinoids to be performed easily within a few hours by monitoring changes of fluorescence intensity with widely available fluorescence microplate readers, without the need for processes such as filtration. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Recommanded Product: 2,5-Dimethyl-2,5-hexanediol

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Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Analysis of the volatile components of Polygonum chinense L. extracted with different solvents by GC-MS》 was published in 2021. The authors were Wei, Anda;Zhu, Hua;Xie, Fengfeng;Zhang, Miao;Huang, Piaoiing;Yang, Wenqi, and the article was included in《Agricultural Biotechnology》. The author mentioned the following in the article:

This study was conducted to investigate the volatile components of Polygonum chinense L. The volatile components of the methanol extract, Et acetate extract, chloroform extract and petroleum ether extract of P. chinense were analyzed and determined by gas chromatog. The volatile components of the methanol extract from P. chinense were the most, and phenolic acids and ketones accounted for a relatively high proportion, among which pyrogallic acid had the highest content. The Et acetate extract contained the second most volatile components, mostly acids and esters, of which ss-sitosterol had the highest content; the chloroform and petroleum ether extracts had relatively few types of volatile components, most of which were alkanes, and the content of -sitosterol shared by the two was the highest. The common substances of the four extracts were palmitic acid and phytol. This study provides a theor. basis for the quality evaluation of P. chinense and a scientific basis for its resource development. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Application In Synthesis of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Wang, Peng;Wang, Junjie;Zhang, Huaiyu;Wang, Cong;Zhao, Lunaike;Huang, Ting;Qing, Ken published 《Chemical Composition, Crystal Morphology, and Key Gene Expression of the Cuticular Waxes of Goji (Lycium barbarum L.) Berries》. The research results were published in《Journal of Agricultural and Food Chemistry》 in 2021.Category: alcohols-buliding-blocks The article conveys some information:

The cuticular wax of fruit is closely related to quality, storability, and pathogen susceptibility after harvest. However, little is known about the cuticular wax of goji berry (Lycium barbarum L.) cultivars. In the present study, the chem. composition, crystal structures, and expression levels of associated genes of the cuticular wax of six goji cultivars were investigated. We detected 70 epicuticular wax compounds in six goji cultivars. Among them, fatty acids, alkanes, and primary alcs. were the major components of the cuticular wax of goji berries, which were related to the formation of irregular lamellar crystal structures. The terpenoid compounds in the cuticular wax of goji berries were highly resistant to Alternaria rot. Moreover, the CER1, CER6, LACS1, MAH1, LTP4, ABC11, MYB96, and WIN1 genes in goji berries might be closely related to wax synthesis. These results provide valuable information for breeding and screening goji cultivars suitable for postharvest storage. To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Category: alcohols-buliding-blocks2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Brzic, Sasa;Kovacevic, Nemanja;Grzetic, Jelena;Bogosavljevic, Marica;Mijatov, Slavko;Bogdanov, Jovica;Kovacevic, Tihomir published 《Multi-component elastomeric composites based on castor oil/AgI/KI for cloud seeding: processing and modeling of reagent efficiency》 in . The article was appeared in 《Polymer Bulletin (Heidelberg, Germany)》. They have made some progress in their research.Product Details of 119-47-1 The article mentions the following:

This study involves the development of sustainable technol./methodol. for the production, characterization and numerical calculation of highly effective multi-component anti-hail seeding reagents (seeding composites) based on silver iodide and iodide of an alkali metal, homogenized in synthetic or bio polyurethane binder. Polyurethane-based seeding composites are produced via casting method and the results of uniaxial tensile tests, hardness and dynamic-mech. anal. show that applied technique is more suitable compared to the conventional dry homogenization of the seeding active agents. Lower viscosity, uniform powd. seeding agents distribution and improved mech. properties, e.g. higher tensile strength (5.05 MPa) and Shore A hardness (89 ShA) are achieved using castor oil as bio-polymer binder, compared to the synthetic polymer hydroxyl terminated poly(butadiene). In addition, significantly higher glass transition temperature obtained for seeding composite with castor oil as polymer binder indicating higher d. and branched polymer network. Numerical models of the convective clouds are used to determine composition and mass of seeding agent which gives the best results concerning hail suppression or rain intensification. Results show that composite seeding reagents which contain silver iodide and potassium iodide in a molar ratio of 1:2 upon combustion generate freezing nuclei which are active above 0 °C, providing the most effective cloud seeding with 10.53% hail accumulations suppression. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Product Details of 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Doiuchi, Daiki;Nakamura, Tatsuya;Hayashi, Hiroki;Uchida, Tatsuya published 《Non-Heme-Type Ruthenium Catalyzed Chemo- and Site-Selective C-H Oxidation》 in 2020. The article was appeared in 《Chemistry – An Asian Journal》. They have made some progress in their research.Recommanded Product: 78-69-3 The article mentions the following:

Herein, a Ru(II)(BPGA) complex that could be used to catalyze chemo- and site-selective C-H oxidation was developed. The described ruthenium complex was designed by replacing one pyridyl group on tris(2-pyridylmethyl)amine with an electron-donating amide ligand that was critical for promoting this type of reaction. More importantly, higher reactivities and better chemo-, and site-selectivities were observed for reactions using the cis-ruthenium complex rather than the trans-one. This reaction could be used to convert sterically less hindered methyne and/or methylene C-H bonds of a various organic substrates, including natural products, into valuable alc. or ketone products. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Chen, Zhao;Li, Yuanli;Liu, Xiaomin;Cui, Zhenggang published 《Dialkyl Sulfobetaine Surfactants Derived from Guerbet Alcohol Polyoxypropylene-Polyoxyethylene Ethers for SP Flooding of High Temperature and High Salinity Reservoirs》. The research results were published in《Journal of Surfactants and Detergents》 in 2021.Electric Literature of C16H34O The article conveys some information:

Dialkyl hydroxypropyl sulfobetaine (HSB) surfactants, C16GA-(PO)5-(EO)3-HSB and C24GA-(PO)10-(EO)10-HSB, were synthesized from Guerbet alcs. (GA) polyoxypropylene-polyoxyethylene (PO-EO) ethers and their behaviors in surfactant-polymer (SP) flooding of high temperature and high salinity reservoirs were examined and compared with their anionic hydroxypropyl sulfonate (HS) counterparts, C16GA-(PO)5-(EO)3-HS and C24GA-(PO)10-(EO)10-HS. The PO-EO chain embedded improves their aqueous solubility, and the sulfobetaines show better salt resistance than sulfonates. For a reservoir condition of total salinity 19,640 mg L-1 and 60-80°C, C16GA-(PO)5-(EO)3-HSB alone can reduce crude oil/connate water interfacial tension (IFT) to ultralow at 0.25-5 mM, which can be further widened to 0.1-5 mM by mixing with dodecylhexyl (C12+6) glyceryl ether hydroxypropyl sulfobetaine (C12+6GE-HSB), a slightly hydrophobic surfactant. C24GA-(PO)10-(EO)10-HSB is more hydrophobic for the specified reservoir condition, however, by mixing with hexadecyl di-Me hydroxypropyl sulfobetaine (C16HSB), a hydrophilic surfactant, ultralow IFT can also be achieved at a total concentration of 0.25-5 mM. The anionic counterparts can also reduce IFT to ultralow by mixing with C12+6GE-HSB and C16HSB, resp. Moreover, the optimum binary mixture, C16GA-(PO)5-(EO)3-HSB/C12+6GE-HSB at a molar fraction ratio of 0.6/0.4, can keep the neg. charged solid surface water-wet (θw = 12-23°) in a wide concentration range, and can still achieve ultralow IFT after stored at 90°C for 90 days (initially 5 mM), which overall are favor of improving oil displacement efficiency at high temperature and high salinity reservoir conditions. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Electric Literature of C16H34O It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Product Details of 80-46-6In 2017, Han, Jie;Cao, Zhi;Qiu, Wei;Gao, Wei;Hu, Jiangyong;Xing, Baoshan published 《Probing the specificity of polyurethane foam as a ‘solid-phase extractant’: Extractability-governing molecular attributes of lipophilic phenolic compounds》. 《Talanta》published the findings. The article contains the following contents:

The long-proposed use of open-cell polyurethane foam (PUF) as a convenient ‘solid-phase extractant’ for aqueous organic compounds was hindered by a critical lack of understanding on the underlying specificity of its extraction mechanism. The authors tasked ourselves to understand the hierarchy of mol. structure, properties, and partitioning characteristics of compounds in PUF and aqueous phase by targeting lipophilic phenolic compounds (LPCs) as a group of primary targets for PUF extraction Using six structurally related bisphenol analogs as comparative probes, the authors identified mol. lipophilicity and H-bond acidity as key mol. attributes that governed their extractability by PUF. Mol. modeling study on H-bonding interactions between PUF surrogates, bisphenols, and water mols. elucidated the governing effect of H-bond acidity in the binding affinity of guest mols. onto PUF lone-pair donors. A holistic view must be adopted when assessing the extractability of LPCs with reactive lone-pair donors e.g. bisphenol S which forms multidentate H-bond adducts with water mols. The authors validated the authors’ theory on two model groups of monofunctional LPCs, alkylphenols and chlorophenols, with the observation that the presence of a 2nd proton-donating moiety dramatically enhanced the extractability of bisphenol mols. The specificity of PUF rendered it selective towards compounds with correlating mol. attributes against other structural analogs and coexisting matrix organics For LPCs, the PUF macromol. structure can be conceptualized as a flexible ‘mol. zipper network’ that is most affinitive towards nonionic, permeable, and lipophilic guest mols. with multiple reactive proton donors. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Product Details of 80-46-6

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