Month: September 2022

HPLC of Formula: 599-64-4《Removal of selected emerging micropollutants from wastewater treatment plant effluent by advanced non-oxidative treatment – A lab-scale case study from Serbia》 was published in 2021. The authors were Bogunovic, Minja;Ivancev-Tumbas, Ivana;Cesen, Marjeta;Sekulic, Tatjana Djakovic;Prodanovic, Jelena;Tubic, Aleksandra;Heath, David;Heath, Ester, and the article was included in《Science of the Total Environment》. The author mentioned the following in the article:

The presence of 48 emerging micropollutants was tested in influent and effluent from primary and secondary treatment at a municipal wastewater treatment plant (WWTP) in Serbia. Sixteen emerging micropollutants (active pharmaceutical ingredients, bisphenols, parabens and UV filters) had concentrations >LOQ (maximum concentrate 33.4μg/L). The removal efficiency of primary treatment ranged from 2.0% – 96.0%. In the case of secondary treatment, except for ketoprofen (61.0%), diclofenac (62.6%) and carbamazepine (-20.0%), all other measured micropollutants had removal efficiency above 77.0%. Advanced non-oxidative lab-scale treatments were investigated. Powd. activated carbon (PAC) adsorption achieved removal efficiencies in the range 52.4-99.9%, novel coagulation with natural coagulant isolated from beans achieved removal efficiencies in range 3.2-99.9%, conventional coagulation with ferric chloride 3.12-96.4%, combined adsorption/coagulation 2.69-99.9% and combined PAC/ultrafiltration (PAC/UF) 60-99.9%. For most of the micropollutants, their removal efficiencies were similar to that reported in the literature. Novel natural coagulant showed significant potential compared to the conventional coagulant during a short episode of sub-optimal WWTP operation. When natural coagulant was applied as a part of an adsorption/coagulation hybrid process, there was no neg. effect on PAC adsorption, while for conventional coagulant that was not always the case. Also, a structure property relationship (SPR) study revealed correlations between the removal efficiency of the majority of treatments applied and total polar surface area (TPSA) of the micropollutants. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.HPLC of Formula: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Hu, Shuangling;Chen, Qinghua;Guo, Fei;Wang, Mingle;Zhao, Hua;Wang, Yu;Ni, Dejiang;Wang, Pu published 《(Z)-3-Hexen-1-ol accumulation enhances hyperosmotic stress tolerance in Camellia sinensis》 in 2020. The article was appeared in 《Plant Molecular Biology》. They have made some progress in their research.Quality Control of 2-Hexyl-1-decanol The article mentions the following:

Volatile components in fresh leaves are involved in the regulation of many stress responses, such as insect damage, fungal infection, high temperature Here, we found that 7-day hyperosmotic treatment specifically led to the accumulation of (Z)-3-hexen-1-ol, (E)-2-hexenal and Me salicylate. (Z)-3-hexen-1-ol pretreatment dramatically enhanced the hyperosmotic stress tolerance of tea plants and decreased stomatal conductance, whereas (E)-2-hexenal and Me salicylate pretreatments did not exhibit. qRT-PCR anal. revealed that exogenous ABA induced the expressions of related enzyme genes, and (Z)-3-hexen-1-ol could up-regulate the expressions of many DREB and RD genes. Moreover, exogenous (Z)-3-hexen-1-ol tremendously induced the expressions of specific LOX and ADH genes within 24 h. Taken together, hyperosmotic stress induced (Z)-3-hexen-1-ol accumulation in tea plant via LOX, HPL and ADH genes, (Z)-3-hexen-1-ol could dramatically enhance the hyperosmotic stress tolerance via the decrease of stomatal conductance and MDA, accumulation of ABA and proline, activation of DREB and RD gene expressions. Key message: Hyperosmotic stress induced (Z)-3-hexen-1-ol accumulation in Camellia sinensis via up-regulation of most LOX, HPL and ADH genes, while (Z)-3-hexen-1-ol could dramatically enhance the hyperosmotic stress tolerance via the decrease of stomatal conductance, accumulation of proline, activation of DREB and RD gene expressions, and probably pos. feedback regulation of LOXs and ADHs. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) may be employed as an organic solvent to study the extraction of non-polar acidic drugs from human plasma by parallel artificial liquid membrane extraction (PALME). Quality Control of 2-Hexyl-1-decanol

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Yang, Lu;Wenzel, Thomas;Williamson, R. Thomas;Christensen, Melodie;Schafer, Wes;Welch, Christopher J. published 《Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity》. The research results were published in《ACS Central Science》 in 2016.Related Products of 579-43-1 The article conveys some information:

The use of NMR chiral solvating agents (CSAs) for the anal. of enantiopurity was known for decades, but was supplanted in recent years by chromatog. enantioseparation technol. While chromatog. methods for the anal. of enantiopurity are now commonplace and easy to implement, there are still individual compounds and entire classes of analytes where enantioseparation can prove extremely difficult, notably, compounds that are chiral by virtue of very subtle differences such as isotopic substitution or small differences in alkyl chain length. NMR anal. using CSAs can often be useful for such problems, but the traditional approach to selection of an appropriate CSA and the development of an NMR-based anal. method often involves a trial-and-error approach that can be relatively slow and tedious. The authors describe a high-throughput experimentation approach to the selection of NMR CSAs that employs automation-enabled screening of prepared libraries of CSAs in a systematic fashion. This approach affords excellent results for a standard set of enantioenriched compounds, providing a valuable comparative data set for the effectiveness of CSAs for different classes of compounds The technique was successfully applied to challenging pharmaceutical development problems that are not amenable to chromatog. solutions Overall, this methodol. provides a rapid and powerful approach for studying enantiopurity that compliments and augments conventional chromatog. approaches.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Related Products of 579-43-1) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2020, Gautier, Francoise;Tourneix, Fleur;Assaf Vandecasteele, Hind;van Vliet, Erwin;Bury, Dagmar;Alepee, Nathalie published 《Read-across can increase confidence in the Next Generation Risk Assessment for skin sensitisation: A case study with resorcinol》. 《Regulatory Toxicology and Pharmacology》published the findings. The article contains the following contents:

Historically skin sensitization risk assessment for cosmetic ingredients was based on animal models, however regulatory demands have led to Next Generation Risk Assessment (NGRA), using data from New Approach Methodologies (NAM) and Defined Approaches (DA). This case study was meant to investigate if the use of resorcinol at 0.2% in a face cream was safe and a maximum use concentration could be defined. The NAM data and DA predictions could not provide sufficient confidence to determine a point of departure (POD). Therefore, the application of read-across was explored to increase the level of confidence. Analog searches in various tools and databases using “mode of action” and “chem. structural features” retrieved 535 analogs. After refinement by excluding analogs without a defined structure, similar reactivity profile and skin sensitization data, 39 analogs remained. A final selection was made based on three approaches: expert judgment, chem. similarity or Local Lymph Node Assay data (LLNA). All read-across approaches supported a moderate potency. A POD derived from the LLNA EC3 of 3.6% was determined leading to a favorable NGRA conclusion and a maximum use concentration of 0.36%. This was supported by a traditional risk assessment based on the available animal data for resorcinol. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2-Hexyl-1-decanol《Bithieno[3,4-c]pyrrole-4,6-dione-Mediated Crystallinity in Large-Bandgap Polymer Donors Directs Charge Transportation and Recombination in Efficient Nonfullerene Polymer Solar Cells》 was published in 2020. The authors were Zhao, Jiaji;Li, Qingduan;Liu, Shengjian;Cao, Zhixiong;Jiao, Xuechen;Cai, Yue-Peng;Huang, Fei, and the article was included in《ACS Energy Letters》. The author mentioned the following in the article:

Solution-processed nonfullerene bulk-heterojunction (BHJ) polymer solar cells (PSCs), which are composed of polymer donors and organic acceptors, are proven to manifest promising performance and long-term stability. In this concise contribution, bithieno[3,4-c]pyrrole-4,6-dione (BiTPD), which is a TPD derivative but presents a large planar structure and strong electron-withdrawing ability, was used to construct a large-bandgap polymer donor PBiTPD. Results show that the polymer donor PBiTPD realized power conversion efficiency (PCE) as high as 14.2% in fullerene-free BHJ solar cells. Larger ionization potential value, more favorable face-on backbone orientation, and stronger crystallinity were concurrently obtained in PBiTPD. Correspondingly, improved and more balanced charge transportation; less nongeminate and trap-assisted recombination losses; and thus high fill factor (FF) of 67%, short-circuit c.d. (Jsc) of 25.6 mA·cm^-2, and high open-circuit voltage (Voc) of 0.83 V were concurrently achieved in PBiTPD-based devices. PBiTPD does clear the way for a novel and promising class of large-bandgap polymer donor candidates.2-Hexyl-1-decanol (cas: 2425-77-6) were involved in the experimental procedure.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Safety of 2-Hexyl-1-decanol This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Category: alcohols-buliding-blocks《Inhibition of colitis by ring-modified analogues of 6-acetamido-2,4,5-trimethylpyridin-3-ol》 was published in 2020. The authors were Chaudhary, Chhabi Lal;Chaudhary, Prakash;Dahal, Sadan;Bae, Dawon;Nam, Tae-gyu;Kim, Jung-Ae;Jeong, Byeong-Seon, and the article was included in《Bioorganic Chemistry》. The author mentioned the following in the article:

6-Aminopyridin-3-ol scaffold has shown an excellent anti-inflammatory bowel disease activity. Various analogs with the scaffold were synthesized in pursuit of the diversity of side chains tethering on the C(6)-position. SAR among the analogs was investigated to understand the effects of the side chains and their linkers on their anti-inflammatory activities. In this study, structural modification moved beyond side chains on the C(6)-position and reached to pyridine ring itself. It expedited to synthesize diverse ring-modified analogs of a representative pyridine-3-ol, 6-acetamido-2,4,5-trimethylpyridin-3-ol. In the evaluation of compounds on their inhibitory actions against TNF-α-induced adhesion of monocytic cells to colonic epithelial cells, an in vitro model mimicking colon inflammation, the effects of compounds I , II, and III were greater than tofacitinib, an orally available anti-colitis drug, and compound dehydroxylated analog II exhibit the greatest activity. In addition, TNF-α-induced angiogenesis, which permits more inflammatory cell migration into inflamed tissues, was significantly blocked by compounds I and II in a concentration-dependent manner. In the comparison of in vivo therapeutic effects of compounds I , II, and III on dextran sulfate sodium (DSS)-induced colitis in mice, compound dehydroxylated analog II was the most potent and efficacious, and compound demethylated analog III was better than compound I which exhibited a similar degree of inhibitory effect to tofacitinib. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Category: alcohols-buliding-blocks) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Dryzhakov, Marian;Moran, Joseph published 《Autocatalytic Friedel-Crafts Reactions of Tertiary Aliphatic Fluorides Initiated by B(C₆F₅)₃·H₂O》. The research results were published in《ACS Catalysis》 in 2016.Name: 3,7-Dimethyloctan-3-ol The article conveys some information:

The C-F bond is the strongest single bond to carbon, constituting an intrinsic challenge for selective catalytic activation in the presence of other functional groups. Existing methods for the activation of tertiary aliphatic fluorides involve stoichiometric abstraction with fluorophilic Lewis acids or by Lewis-acid-catalyzed trapping with Si reagents. Herein, we describe a B(C₆F₅)₃·H₂O-catalyzed Friedel-Crafts reaction of tertiary alkyl fluorides that proceeds rapidly at room temperature without trapping reagents. The method is completely selective for F^– over traditionally better leaving groups and displays an autocatalytic kinetic profile. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Name: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Wakayama, Hideki;Sakasai, Mitsuyoshi;Yoshikawa, Keiichi;Inoue, Michiaki published 《Method for Predicting Odor Intensity of Perfumery Raw Materials Using Dose-Response Curve Database》. The research results were published in《Industrial & Engineering Chemistry Research》 in 2019.Quality Control of 3,7-Dimethyloctan-3-ol The article conveys some information:

The main purpose of this study is to facilitate fragrance development on the basis of scientific knowledge. To this end, data on 314 perfumery raw materials (PRMs) showing the relationship between PRM odor intensity and gas concentration were obtained, and a calculation model for the data was then developed with the following features: (1) maximum PRM coverage, (2) calculating values implying odor intensity from only arbitrary gas concentration, and (3) estimating odor intensity from the calculated values directly and easily. To verify the prediction accuracy of this model, the predicted odor intensity was compared with the evaluated value for both single component and a mixture, and the same degree of root mean square error (RMSE) was confirmed. RMSE in the single component was 6.22 while that in the mixture was 6.69. Thus, the odor intensity of a PRM or mixture can be predicted from arbitrary gas concentrations And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Quality Control of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Abd-Alla, Howaida I.;Taie, Hanan A. A.;Abd-Elmotaleb, Marwa M. published 《Comparative phytochemical and biological investigation of five Glycine max (L.) Merrill genotypes》 in 2019. The article was appeared in 《Asian Journal of Pharmaceutical and Clinical Research》. They have made some progress in their research.COA of Formula: C8H18O2 The article mentions the following:

Soybean (Glycine max L. Merrill) is the world′s most important consumed seed legume. The objectives of the present study were to determine the variability in phytochem. composition and biol. activities between five genotypes of G. maximum Lipoidal matters were determined using glucose (GLC). Amino acids were detected by the amino acid analyzer. The phytoconstituents present within each ethanol extract was investigated by gas chromatog.-mass spectrometry. The amount of total phenolics, flavonoids, and tannins was analyzed using a spectrophotometric technique, based on Folin-Ciocalteu reagent, aluminum chloride colorimetric assay, and the modified vanillin hydrochloric acid method, resp. Quercetin, catechin, and gallic acid were used as standard compounds, resp. Isoflavones content were detected by high-performance liquid chromatog. (HPLC)/photodiode array (PDA). The radical scavenging and antioxidant capacity of the genotypes using different in vitro anal. assays such as 2,2-di-Ph,1-picryl hydrazyl, 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), reducing power, metal chelating, and ferric reducing anti-oxidant power. Bu hydroxyl toluene and trolox were used as the reference antioxidant radical scavenger compounds Antitumor activity was evaluated by detecting the viability of Ehrlich ascites carcinoma cells on four different concentrations (1-5 mg/mL). GLC anal. showed the high value of total unsaturated fatty acids and 16 amino acids including glutamic acid with the highest concentration The variation between genotypes according to their chem. composition of the aldehydes, esters, ketones, alcoholics, and carboxylic content were reported. HPLC/PDA referred to the presence of daidzein, genistein, and in all genotypes. The results confirm the higher value of phytoconstituents of the genotype Giza 35 and Giza 21 as well as their better bioactivity. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.COA of Formula: C8H18O2

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Chen, Zong-yan;Wu, Xiao-lan;Ma, Jun;Xiao, Li;Wang, Tao;Lu, Hui-yi published 《Preparation of high quality tetrachloroethylene by impurity removal method》 in 2018. The article was appeared in 《Huaxue Shiji》. They have made some progress in their research.Application In Synthesis of 4-tert-Amylphenol The article mentions the following:

The purification process of tetrachloroethylene was investigated. The methods of extraction, adsorption, distillation separation and purification of tetrachloroethylene feasibility, and the parameters are optimized. The purity of tetrachloroethylene is improved because of the reduction of p-tert-amylphenol and other impurities. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Application In Synthesis of 4-tert-Amylphenol

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