Month: September 2022

Reference of 3,7-Dimethyloctan-3-olIn 2018, Malysheva, A. G.;Kozlova, N. Yu.;Yudin, S. M. published 《The unaccounted hazard of processes of substances transformation in the environment in the assessment of the effectiveness of the application of technologies》. 《Gigiena i Sanitariya》published the findings. The article contains the following contents:

To solve environmental problems in the current economic conditions, the use of achievements in scientific and technol. progress acquires the special significance. This primarily concerns the creation, optimization, and improvement of environmentally friendly technologies for purification and neutralization of industrial emissions, new technologies for purification and disinfection of drinking water, development and implementation of environment improving phytotechnologies and many other environmental and health-improving measures. The present system of environmental and anal. monitoring of the state of environmental objects exposed to various technologies for its recovery, based on the use of phys. and chem. or biol. factors, requires the control of chem. safety, taking into account the possibility of formation of byproducts of transformation with respect to their harmlessness for use. The studies were performed using a chromatog.-mass spectrometric system including a gas chromatograph with full electronic control of gas flows and a digital pressure and flow control mode with automatic determination of column parameters, mass spectrometric detector with a quadrupole mass analyzer that provides measurements in the range of mass numbers from 1 to 1050, and a thermal desorber with a gas sample cryo-focusing. Examples of assessing the effectiveness and chem. safety of the application of new environmental protection technologies for cleaning air emissions from a number of enterprises and measures for improving the air environment of enclosed spaces show that their application, on the one hand, is aimed at directly addressing their specific purpose, i.e., a significant reduction in the qual. and quant. composition of pollutants in production emissions has been established, including an important component in terms of environmental aspects, such as the smell and on the other hand – a neg. side effect associated with the formation of toxic and dangerous products of transformation is simultaneously established, even for substances of natural origin, a significant part of which does not have hygienic standards, and consequently their impact on public health remains unaccounted. The side effect was often manifested by a change in the direction of deterioration in the chem. composition of the environment object that is phys. and chem. affected by the use of the new technol. For an adequate assessment of the quality of the environment and chem. safety of public health, an important condition is to take into account the multicomponent nature of the composition of chem. contaminants and to take into account the transformation products of substances affecting humans under real environmental conditions. Studies focused on identification with a quant. assessment of air emission components before and after the application of a new environmental technol. or a better environmental and health improvement measure allow to monitor environmental objects taking into account the actual content and changes in the group and component composition under the influence of the chem. impact of new technol. and to make recommendations for further improvement of the new technol. from the point of view of environmental aspects, which, in turn, is aimed at preserving the health of the population. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Reference of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Gurkan-Alp, A. Selen;Mumcuoglu, Mine;Andac, Cenk A.;Dayanc, Emre;Cetin-Atalay, Rengul;Buyukbingol, Erdem published 《Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives》. The research results were published in《European Journal of Medicinal Chemistry》 in 2012.HPLC of Formula: 110-03-2 The article conveys some information:

In this study, novel (E)-3-(5-substituted-1H-indol-3-yl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one derivatives were synthesized and their anticancer effects were determined in vitro. Novel indole retinoid compounds have anti-proliferative capacity in liver, breast, and colon cancer cell lines. This anti-proliferative effect was further analyzed in breast cancer cell line panel by using the most potent compound The latter can inhibit proliferation at very low IC₅₀ concentrations in all of the breast cancer cell lines. Here, we present some evidence on apoptotic termination of cancer cell proliferation which may be primarily driven by the inhibition of RXRα and, to a lesser extent, RXRγ. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.HPLC of Formula: 110-03-2

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HPLC of Formula: 599-64-4In 2020, Medvedev, Alexander V.;Medvedeva, Lyubov A.;Martsen, Elena;Moeser, Mathew;Gorman, Kristen L.;Lin, Benjamin;Blackwell, Brett;Villeneuve, Daniel L.;Houck, Keith A.;Crofton, Kevin M.;Makarov, Sergei S. published 《Harmonized Cross-Species Assessment of Endocrine and Metabolic Disruptors by Ecotox FACTORIAL Assay》. 《Environmental Science & Technology》published the findings. The article contains the following contents:

Environmental pollution is a threat to humans and wildlife species. Of particular concern are endocrine disrupting chems. (EDCs). An important target of EDCs is nuclear receptors (NRs) that control endocrine and metabolic responses through transcriptional regulation. Owing in part to structural differences of NRs, adverse effects of EDCs vary significantly among species. Here, we describe a multiplexed reporter assay (the Ecotox FACTORIAL) enabling parallel assessment of compounds’ effects on estrogen, androgen, thyroid, and PPARγ receptors of representative mammals, birds, reptiles, amphibians, and fish. The Ecotox FACTORIAL is a single-well assay comprising a set of species-specific, one-hybrid GAL4-NR reporter constructs transiently transfected into test cells. To harmonize cross-species assessments, we used a combination of two approaches. First, we used the same type of test cells for all reporters; second, we implemented a parallel detection of reporter RNAs. The assay demonstrated excellent quality, reproducibility, and insignificant intra-assay variability. Importantly, the EC₅₀ values for NR ligands were consistent with those reported for conventional assays. Using the assay allowed ranking the hazard potential of environmental pollutants (e.g., bisphenols, polycyclic aromatic hydrocarbons, and synthetic progestins) across species. Furthermore, the assay permitted detecting taxa-specific effects of surface water samples. Therefore, the Ecotox FACTORIAL enables harmonized assessment of the endocrine and metabolic disrupting activity of chems. and surface water in humans as well as in wildlife species. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.HPLC of Formula: 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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Electric Literature of C15H16O《Access to Chiral Bisphenol Ligands (BPOL) through Desymmetrizing Asymmetric Ortho-Selective Halogenation》 was published in 2020. The authors were Xiong, Xiaodong;Zheng, Tianyu;Wang, Xinyan;Tse, Ying-Lung Steve;Yeung, Ying-Yeung, and the article was included in《Chem》. The author mentioned the following in the article:

A facile strategy to prepare potent chiral bisphenols (BPOLs) through the desymmetrizing asym. ortho-halogenation was described. Both theor. and exptl. studies were conducted in order to shed light on the mechanistic picture. The halogen handles in the BPOL products were manipulated to yield unsym. chiral BPOL ligands, which were potential privileged catalyst scaffolds and was applied in other asym. catalytic reactions.4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) were involved in the experimental procedure.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Electric Literature of C15H16O 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

Reference:
Alcohol – Wikipedia,
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Recommanded Product: 579-43-1In 2017, Mecozzi, Francesco;Dong, Jia Jia;Saisaha, Pattama;Browne, Wesley R. published 《Oxidation of Vicinal Diols to α-Hydroxy Ketones with H₂O₂ and a Simple Manganese Catalyst》. 《European Journal of Organic Chemistry》published the findings. The article contains the following contents:

α-Hydroxy ketones are valuable synthons in organic chem. Here we show that oxidation of vic-diols to α-hydroxy ketones with H₂O₂ can be achieved with an in situ prepared catalyst based on manganese salts and pyridine-2-carboxylic acid. Furthermore the same catalyst is effective in alkene epoxidation, and it is shown that alkene oxidation with the Mn^II catalyst and H₂O₂ followed by Lewis acid ring opening of the epoxide and subsequent oxidation of the alkene to α-hydroxy ketones can be achieved under mild (ambient) conditions. To complete the study, the researchers used rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) .

Desymmetrization of rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas:579-43-1 Recommanded Product: 579-43-1) using chiral phosphine catalyst has been reported. Conversion of meso-hydrobenzoin to trans-stillbene oxide by treatment with an aryl sulfonyl chloride and aqueous sodium hydroxide has been reported.

Reference:
Alcohol – Wikipedia,
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Today I want to share an article with you. The article is 《Impact of crossflow microfiltration on aroma and sensory profiles of a potential functional citrus-based food》,you can find this article in 《Journal of the Science of Food and Agriculture》. The following contents are mentioned:

Citrus juices can be cold-concentrated by crossflow microfiltration (CMF) in order to obtain functional foods enriched in carotenoids, flavonoids and pectins. The work aimed to characterize the organoleptic quality of this type of micronutrient-dense foods through their aroma profile and sensory anal. Two citrus concentrates with and without a diafiltration step were compared. Both citrus products were very different, linked to aroma compound, sugar and organic acid contents. Due to its sugar/acidity balance and its better aromatic profile responsible for the citrus-floral flavor, the concentrate without diafiltration was preferred by the sensory panel. Thanks to a simple transfer model, we showed that retention of volatiles clearly varied from one aroma compound to another. The terpene hydrocarbons were the most retained by the membrane during CMF, probably because they were strongly associated with insoluble solids by adsorption. Even though the process modified their organoleptic profiles, both citrus-based products were well rated and can be consumed directly as pleasant functional drinks.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Fen;Song, Yaqin;Liu, Shaohui;Nie, Jun;He, Yong published 《Preparation of polymerizable thermal initiator and its application in photo-induced thermal frontal polymerization》 in 2019. The article was appeared in 《European Polymer Journal》. They have made some progress in their research.Related Products of 110-03-2 The article mentions the following:

Photo-induced frontal polymerization has been growing interesting in the recent decades. However, the conflict among the frontal starting temperature, the storage stability and the high leachability remain problems to be solved. A new polymerizable methacrylate functionalized aliphatic peroxide thermal initiator (named as IEM-HDHP) through modifying methacrylate group into the 2,5-dihydroperoxy-2,5-dimethylhexane (HDHP) was successfully prepared In the photo-induced frontal polymerization investigated, IEM-HDHP showed medium photo-induced frontal polymerization starting temperature, frontal velocity and best storage stability compared with two com. thermal initiators (benzoyl peroxide (BPO) and 1-(2-hydroperoxypropan-2-yl) benzene) (CHP). What’s more, the lowest amount of small mol. leachability makes it outstanding from the two competitors. At the same time, IEM-HDHP is the only one to lead to the sample stick with complete and smooth appearance in this work. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Related Products of 110-03-2

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Alcohol – Wikipedia,
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Wang, Yali;Yang, Lu;Zhang, Ke;Chen, Xiaoxiang;Wang, Hangyu;Cheng, Ping;Wang, Jinhui published 《Untargeted metabolomics analysis of different grape varieties and different parts of wine grape using gas chromatography and mass spectrometry technique》. The research results were published in《Journal of Biobased Materials and Bioenergy》 in 2021.Recommanded Product: 2425-77-6 The article conveys some information:

Natural active compounds are an important key to the development and utilization of functional foods and medicine. In this study, the chem. diversity and varietal differences of wine grape were studied by using the untargeted metabolomics method based on gas chromatog.-mass spectrometry (GC-MS), and the secondary metabolites of different cultivars and different parts were analyzed. A GC-MS-based metabolomic approach and chemometrics tools was used to identify potential active compounds in Vitis vinifera. The results showed that the content of active compounds in red wine varieties was higher than that in white wine varieties, and the content of active ingredients in grape seeds was significantly higher than that in fruits. In conclusion, this study analyzed the metabolite composition and differentiation of different wine grape fruits in Turpan as a whole, and is expected to lay a foundation for the study of wine grape and to provide a theor. basis for development and utilization of the Dietary supplement and medicine on them. The experimental procedure involved many compounds, such as 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) is a fatty acid that is found in the essential oils of plants and has been shown to have fungicidal properties.Recommanded Product: 2425-77-6 It has also been shown to inhibit the growth of Candida glabrata when used as a cationic surfactant.

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Alcohol – Wikipedia,
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Guo, Pengfei;Liao, Shengyun;Wang, Shun;Shi, Jing;Tong, Xinli published 《Highly efficient and selectivity-controllable aerobic oxidative cleavage of C-C bond over heterogeneous Fe-based catalysts》. The research results were published in《Journal of Catalysis》 in 2021.Synthetic Route of C14H14O2 The article conveys some information:

A base-free selectivity-controllable aerobic oxidative cleavage of C-C bond with heterogeneous Fe-based catalysts (Fe_xO_y-N@C₃N₄) was developed. In the presence of oxygen, 1,2-diols were selectively transformed to the corresponding aldehyde, while the Me esters were orientedly produced from 1,2-diones in methanol medium.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.

rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Synthetic Route of C14H14O2) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.

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SDS of cas: 148-51-6In 1940, Harris, Stanton A. published 《Vitamin B₆. II. Reactions and derivatives》. 《Journal of the American Chemical Society》published the findings. The article contains the following contents:

Vitamin B₆-HCl (I) in an equal mixture of C₅H₅N and Ac₂O, allowed to stand overnight and then heated on a steam bath for 20 min., gives vitamin B₆ triacetate-HCl [2-methyl-3-acetoxy-4,5-bis(acetoxymethyl)-pyridine-HCl], m. 157°; it is stable in 0.01 N HCl but is slowly hydrolyzed in 0.01 N alkali at 37°. Vitamin B₆ dibromide-HBr (II) and 3 equivalents AcOAg in a 22% solution of AcOK in AcOH, heated on the steam bath for 0.5 hrs., give 25% of vitamin B₆ diacetate-HCl [2-methyl-3-hydroxy-4,5-bis(acetoxymethyl) pyridine-HCl], m. 160-1°; the aqueous solution gives a good FeCl₃ test; it has the same relative stability as the tri-Ac derivative Reduction of II with a PdBaSO₄ catalyst in EtOH gives 40% of 2,4,5-trimethyl-3-hydroxypyridine, m. 178°; HCl salt, m. 216°. Catalytic reduction of I with the Adams catalyst gives 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine-HCl, m. 267-8°; this is weakly active for the growth and promotion of acid formation by Streptobacterium plantarum, whereas III is inactive. I, exactly neutralized with 1 equivalent of MeONa in MeOH and heated at 125° for 4 hrs., gives a small yield of 2-methyl-3-hydroxy-4-methoxymethyl-5-hydroxymethylpyridine-HCl (III), m. 181°. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 SDS of cas: 148-51-6) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

Reference:
Alcohol – Wikipedia,
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