Month: September 2022

Recommanded Product: 2425-77-6《Exploration on varying patterns of morphological features and quality of armeniacae semen amarum in rancid process based on colorimeter, electronic nose, and GC/MS coupled with human panel》 was published in 2022. The authors were Shao, Yuanyang;Chen, Huirong;Lin, Hongxin;Feng, Huishang;Gong, Jianting;Cao, Guangzhao;Hong, Weifeng;Yao, Yuebao;Zou, Huiqin;Yan, Yonghong, and the article was included in《Frontiers in Pharmacology》. The author mentioned the following in the article:

In recent years, the domestic and international trade volumes of Chinese medicinal materials (CMMs) keep increasing. By the end of 2019, the total amount of exported CMMs reached as high as US $1.137 billion, while imported was US $2.155 billion. A stable and controllable quality system of CMMs apparently becomes the most important issue, which needs multifaceted collaboration from harvesting CMMs at a proper season to storing CMMs at a proper temperature However, due to imperfect storage conditions, different kinds of deteriorations are prone to occur, for instance, get moldy or rancid, which not only causes a huge waste of CMM resources but also poses a great threat to clin. medication safety and public health. The key issue is to quickly and accurately distinguish deteriorated CMM samples so as to avoid consuming low-quality or even harmful CMMs. However, some attention has been paid to study the changing quality of deteriorated CMMs and a suitable method for identifying them. In this study, as a medicine and food material which easily becomes rancid, armeniacae semen amarum (ASA) was chosen as a research objective, and exptl. ASA samples of different rancidness degrees were collected. Then, various kinds of anal. methods and technologies were applied to explore the changing rules of ASA quality and figure out the key indicators for the quality evaluation of ASA in the rancid process, including the human panel, colorimeter, electronic nose, and GC/MS. This study aims to analyze the correlation between the external morphol. features and the inner chem. compounds, to find out the specific components from ”quant. change” to ”qual. change” in the process of ”getting rancid,” and to discover the dynamic changes in the aforementioned key indicators at different stages of rancidness. The results showed since ASA samples began to get rancid with the extension of storage time, morphol. features, namely, surface color and smell, changed significantly, and the degree of rancidness further deepened at the same time. Based on macroscopic identification accomplished via the human panel, ASA samples with varying degrees of rancidness were divided into four groups. The result of colorimeter anal. was in agreement with that of the human panel, as well as the determination of the amygdalin content and peroxide value. Moreover, there were obvious differences in the amygdalin content and peroxide value among ASA samples with different rancidness degrees. With a higher degree of rancidness, the content of amygdalin decreased, while the peroxide value increased significantly. The rancidness degree of ASA has a neg. correlation with the amygdalin content and a pos. correlation with the peroxide value. The newly discovered nonanal and 2-bromopropiophenone in rancid ASA samples may be the key components of ”rancidity smell,” and these two components would be the exclusive components that trigger ”quant. change” to ”qual. change” in the process of rancidness of ASA. This study sheds light on studying the internal mechanism of ”rancidness” of CMMs and provides an important basis for the effective storage and safe medication of easy-to-get rancid herbs, and it also plays an important foundation for the establishment of a stable and controllable quality system for CMMs. And 2-Hexyl-1-decanol (cas: 2425-77-6) was used in the research process.

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Recommanded Product: 2425-77-6 This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

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Serwa, Remigiusz;Nam, Tae-gyu;Valgimigli, Luca;Culbertson, Sean;Rector, Christopher L.;Jeong, Byeong-Seon;Pratt, Derek A.;Porter, Ned A. published 《Preparation and Investigation of Vitamin B₆-Derived Aminopyridinol Antioxidants》. The research results were published in《Chemistry – A European Journal》 in 2010.HPLC of Formula: 148-51-6 The article conveys some information:

3-Pyridinols bearing amine substitution para to the hydroxylic moiety have previously been shown to inhibit lipid peroxidation more effectively than typical phenolic antioxidants, for example, α-tocopherol. We report here high-yielding, large-scale syntheses of mono- and bicyclic aminopyridinols from pyridoxine hydrochloride (i.e., vitamin B₆). This approach provides straightforward, scaleable access to novel, potent, mol. scaffolds whose antioxidant properties have been investigated in homogeneous solutions and in liposomal vesicles. These mol. aggregates mimic cell membranes that are the targets of oxidative damage in vivo. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 HPLC of Formula: 148-51-6) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Yi, Zhi-ying;Feng, Tao;Li, Xiao-bei;Bing, Fang-ling published 《Preliminary study on glycosidically bound aroma compounds from pomegranate juice》. The research results were published in《Xiandai Shipin Keji》 in 2017.HPLC of Formula: 78-69-3 The article conveys some information:

The characteristic absorption peaks of glycosidically bound aroma precursors from pomegranate juice were initially identified from UV-visible spectra. The aglycons and the glycones were determined by HPLC and GC-MS anal. before and after enzymic hydrolysis. The glycosidically bound aroma precursors were analyzed by monitoring the evolution of thephysicochem. properties of pomegranate juice without or with enzymic hydrolysis. Characteristic absorption peaks of the glycosides were obtained using UV-visible spectra. The total soluble solid and reducing sugar content of the pomegranate juice showed significant differences for the samples treated with and without enzymic hydrolysis. Glucose and fructose were determined as sugar moieties of the glycosides in pomegranate juice by HPLC anal. A total of 36 volatile compounds were identified by GC-MS, and the bound aromas detected in the juice were mostly aromatic alcs., terpenes, and aldehydes, which mainly included 1-hexyl alc., cis-3-hexen-1-ol, tetrahydrolinalool, and phenethyl alc. The results provide evidence to further explain the structure of glycosidically bound aroma precursors from pomegranate juice. And 3,7-Dimethyloctan-3-ol (cas: 78-69-3) was used in the research process.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.HPLC of Formula: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Formula: C8H12ClNO2《Synthesis of aflatoxins by the non-growing mycelia of Aspergillus parasiticus and the effect of inhibitors》 was published in 1975. The authors were Gupta, S. R.;Prasanna, H. R.;Viswanathan, L.;Venkitasubramanian, T. A., and the article was included in《Journal of General Microbiology》. The author mentioned the following in the article:

Aflatoxins were synthesized by nongrowing mycelia of A. parasiticus, the amount and type (B or G) being dependent on the buffer used in the suspension medium. Incorporation of acetate-14C into aflatoxin was decreased by compounds that inhibit ATP production or interfere with the utilization of certain amino acids. In contrast, the specific activities of aflatoxins were increased by compounds that diverted acetate from metabolic pathways other than those leading to aflatoxin formation. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.

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Wang, Jiabao;Gong, Yuxin;Sun, Deli;Gong, Hegui published 《Nickel-catalyzed reductive benzylation of tertiary alkyl halides with benzyl chlorides and chloroformates》 in 2021. The article was appeared in 《Organic Chemistry Frontiers》. They have made some progress in their research.Recommanded Product: 3,7-Dimethyloctan-3-ol The article mentions the following:

Ni-Catalyzed reductive cross-coupling of tertiary alkyl halides with benzyl chlorides and chloroformates has been developed, which provides an efficient method for the construction of benzylated all-carbon quaternary centers in moderate to excellent yields with high functional group tolerance. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
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Tang, Shuqin;Sun, Xiangfei;Qiao, Xinhang;Cui, Wenxuan;Yu, Feixiang;Zeng, Xiaowen;Covaci, Adrian;Chen, Da published 《Prenatal Exposure to Emerging Plasticizers and Synthetic Antioxidants and Their Potency to Cross Human Placenta》 in 2022. The article was appeared in 《Environmental Science & Technology》. They have made some progress in their research.Formula: C14H22O The article mentions the following:

Gestational exposure to environmental chems. and subsequent permeation through the placental barrier represents potential health risks to both pregnant women and their fetuses. In the present study, we explored prenatal exposure to a suite of 46 emerging plasticizers and synthetic antioxidants (including five transformation products of 2,6-di-tert-butyl-4-hydroxytoluene, BHT) and their potency to cross human placenta based on a total of 109 maternal and cord serum pairs. Most of these chems. have rarely or never been investigated for prenatal exposure and associated health risks. Eleven of them exhibited detection frequency greater than 50% in maternal blood, including di-Bu fumarate (DBF), 2,6-di-tert-butylphenol (2,4-DtBP), 1,3-diphenylguanidine (DPG), methyl-2-(benzoyl)benzoate (MBB), tri-Et citrate (TEC), BHT, and its five metabolites, with a median concentration from 0.05 to 3.1 ng/mL. The transplacental transfer efficiency (TTE) was determined for selected chems. with valid measurements in more than 10 maternal/cord blood pairs, and the mean TTEs exhibited a large variation (i.e., 0.29-2.14) between chems. The determined TTEs for some of the target chems. were comparable to the predicted values by our previously proposed models developed from mol. descriptors, indicating that their transplacental transfer potency could be largely affected by physicochem. properties and mol. structures. However, addnl. biol. and physiol. factors may influence the potency of environmental chems. to cross human placenta. Overall, our study findings raise concern on human exposure to an increasing list of plastic additives during critical life stages (e.g., pregnancy) and potential health risks. To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .

4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Formula: C14H22O

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Braga, Soraia Cristina Gonzaga Neves;Oliveira, Luciana Fontes;Reis de Andrade Silva, Adriana;Efraim, Priscilla;de Jesus Poppi, Ronei;Augusto, Fabio published 《Harvest influence in volatile composition of chocolates produced with hybrid varieties of Bahia’s cocoa was investigated using GC × GC-QMS and chemometrics》. The research results were published in《BrJAC–Brazilian Journal of Analytical Chemistry》 in 2019.Category: alcohols-buliding-blocks The article conveys some information:

Cocoa varieties are important in Brazil due to their resistance to “witch’s broom” disease. In this work, the chromatog. profiles of chocolates produced from eleven cocoa varieties harvested from two different harvests were analyzed. A total of 22 samples were analyzed by comprehensive two-dimensional gas chromatog. coupled to mass spectrometry (GC × GC-MS), using headspace solid phase microextration (HS-SPME). Multiway principal component anal. (MPCA) were conducted to study the differences between the two harvests. Two principal components were responsible for the separation of the profiles between the harvests and their resp. loadings were evaluated. Hydrocarbons were the principal group responsible for this separation, as some pyrazines and aldehydes. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Category: alcohols-buliding-blocks Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
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Hatairaktham, Suneerat;Masaratana, Patarabutr;Hantaweepant, Chattree;Srisawat, Chatchawan;Sirivatanauksorn, Vorapan;Siritanaratkul, Noppadol;Panichkul, Narumol;Kalpravidh, Ruchaneekorn W. published 《Curcuminoids supplementation ameliorates iron overload, oxidative stress, hypercoagulability, and inflammation in non-transfusion-dependent β-thalassemia/Hb E patients》 in 2021. The article was appeared in 《Annals of Hematology》. They have made some progress in their research.Recommanded Product: 119-47-1 The article mentions the following:

Curcuminoids, polyphenol compounds in turmeric, possess several pharmacol. properties including antioxidant, iron-chelating, and anti-inflammatory activities. Effects of curcuminoids in thalassemia patients have been explored in a limited number of studies using different doses of curcuminoids. The present study aims to evaluate the effects of 24-wk curcuminoids supplementation at the dosage of 500 and 1000 mg/day on iron overload, oxidative stress, hypercoagulability, and inflammation in non-transfused β-thalassemia/Hb E patients. In general, both curcuminoids dosages significantly lowered the levels of oxidative stress, hypercoagulability, and inflammatory markers in the patients. In contrast, reductions in iron parameter levels were more remarkable in the 1000 mg/day group. Subgroup anal. revealed that a marker of hypercoagulability was significantly decreased only in patients with baseline ferritin ≤ 1000 ng/mL independently of curcuminoids dosage. Moreover, the alleviation of iron loading parameters was more remarkable in patients with baseline ferritin > 1000 ng/mL who receive 1000 mg/day curcuminoids. On the other hand, the responses of oxidative stress markers were higher with 500 mg/day curcuminoids regardless of baseline ferritin levels. Our study suggests that baseline ferritin levels should be considered in the supplementation of curcuminoids and the appropriate curcuminoids dosage might differ according to the required therapeutic effect. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Recommanded Product: 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Teshima, Yoshikazu;Saito, Masahiko;Mikie, Tsubasa;Komeyama, Kimihiro;Osaka, Itaru published 《Bithiazole Dicarboxylate Ester: An Easily Accessible Electron-Deficient Building Unit for π-Conjugated Polymers Enabling Electron Transport》 in 2021. The article was appeared in 《Macromolecules (Washington, DC, United States)》. They have made some progress in their research.Synthetic Route of C16H34O The article mentions the following:

Thiazole has been less focused, compared to thiophene, as the building unit for π-conjugated polymers that are used in organic electronic devices despite its electron deficiency and ability to coplanarize the polymer backbone, which are crucial for design of such π-conjugated polymers. Here, we show that bithiazole dicarboxylate ester (BETz), which is quite easily synthesized, is a promising building unit for π-conjugated polymers. Copolymers based on BETz, having unsubstituted bithiophene and bithiazole as counits, indeed form highly crystalline structures in thin films, which is beneficial for semiconducting properties. Of particular interest is that the BETz-based polymers are found to show electron-transport property even though the LUMO energy levels are not very low, as they show ambipolar and unipolar n-channel behaviors depending on the counit in organic transistor devices. We believe that BETz allows us to design a wide variety of π-conjugated polymers that provide fascinating functions in organic electronic devices. To complete the study, the researchers used 2-Hexyl-1-decanol (cas: 2425-77-6) .

2-Hexyl-1-decanol(cas: 2425-77-6) has been shown to inhibit the growth of b16 mouse melanoma cells, suggesting it may be useful for treating skin cancer.Synthetic Route of C16H34O This fatty acid also has transport properties and can form hydrogen bonds with other molecules.

Reference:
Alcohol – Wikipedia,
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Product Details of 599-64-4《Cobalt-Nanoparticles Catalyzed Efficient and Selective Hydrogenation of Aromatic Hydrocarbons》 was published in 2019. The authors were Murugesan, Kathiravan;Senthamarai, Thirusangumurugan;Alshammari, Ahmad S.;Altamimi, Rashid M.;Kreyenschulte, Carsten;Pohl, Marga-Martina;Lund, Henrik;Jagadeesh, Rajenahally V.;Beller, Matthias, and the article was included in《ACS Catalysis》. The author mentioned the following in the article:

The development of inexpensive and practical catalysts for arene hydrogenations is key for future valorizations of this general feedstock. Here, we report the development of cobalt nanoparticles supported on silica as selective and general catalysts for such reactions. The specific nanoparticles were prepared by assembling cobalt-pyromellitic acid-piperazine coordination polymer on com. silica and subsequent pyrolysis. Applying the optimal nanocatalyst, industrial bulk, substituted, and functionalized arenes as well as polycyclic aromatic hydrocarbons are selectively hydrogenated to obtain cyclohexane-based compounds under industrially viable and scalable conditions. The applicability of this hydrogenation methodol. is presented for the storage of H₂ in liquid organic hydrogen carriers. And 4-(2-Phenylpropan-2-yl)phenol (cas: 599-64-4) was used in the research process.

4-(2-Phenylpropan-2-yl)phenol(cas:599-64-4) is a natural product found in Panax ginseng.Product Details of 599-64-4 4-(2-Phenylpropan-2-yl)phenol is a useful reagent for preparing and characterizing aromatic polyphosphonates as high refractive index polymers.

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