Category: alcohols-buliding-blocksIn 2022, Li, Yong-Qing;Wang, Luo-Yi;Wang, Quan-chao;Hu, Yu-Cai;Ci, Yu-Chen;Cao, Yu-Cai published 《Synthesis and characterization of new benzyl-protected 2-iodo-4-tert-octylphenol and its application in preparation of 1-benzyloxy-2-(3,6-di-tert-butyl-9H-carbazolyl)-4-tert-octylbenzene》. 《Chemical Papers》published the findings. The article contains the following contents:
1-Benzyloxy-2-iodo-4-tert-octylbenzene was synthesized with new methods from 4-tert-octylphenol via bromination, benzyl protection and halogen exchange reaction. Improved yield and easy purification benefit this method. The effects of solvents and ligands in halogen exchange reaction were studied in detail. The synthesized 1-benzyloxy-2-iodo-4-tert-octylbenzene was further examined for its application in Ullmann coupling reaction for preparation of 1-benzyloxy-2-(3,6-di-tert-butyl-9H-carbazolyl)-4-tert-octylbenzene. These newly synthesized compounds were characterized by IR, GC, 1H NMR, 13C NMR, GC-MS and HRMS. And 4-tert-Octylphenol (cas: 140-66-9) was used in the research process.
4-tert-Octylphenol(cas: 140-66-9) has been used as a reference standard for the determination of the analyte in water samples using ultra-high-performance liquid chromatography/tandem mass spectrometry (UHPLC/MS/MS).Category: alcohols-buliding-blocks
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts