Recommanded Product: 140-66-9《Gonadal Soma-Derived Factor Expression is a Potential Biomarker for Predicting the Effects of Endocrine-Disrupting Chemicals on Gonadal Differentiation in Japanese Medaka (Oryzias Latipes)》 was published in 2022. The authors were Horie, Yoshifumi;Kanazawa, Nobuhiro;Takahashi, Chiho;Tatarazako, Norihisa;Iguchi, Taisen, and the article was included in《Environmental Toxicology and Chemistry》. The author mentioned the following in the article:
Chems. with androgenic or estrogenic activity induce the sex reversal and/or intersex condition in various teleost fish species. Previously, we reported that exposure to 17α-methyltestosterone, bisphenol A, or 4-nonylphenol induces changes in expression of the gonadal soma-derived factor (gsdf) gene accompanied by disruption of gonadal differentiation in Japanese medaka (Oryzias latipes). These findings suggest that gsdf expression might be a useful biomarker for predicting the potential effect of chems. on gonadal differentiation. We examined the gsdf expression in Japanese medaka exposed to chems. with estrogenic or androgenic activity. Exposure to the androgenic steroid 17β-trenbolone at 0.5-22.1μg/L induced the development of ovotestis (presence of ovarian tissue with testicular tissue) and female-to-male sex reversal in XX embryos, and exposure at 6.32 and 22.1μg/L significantly increased gsdf expression in XX embryos compared with controls at developmental stage 38 (1 day before hatching). In the present study, no statistically significant difference in gsdf mRNA expression was observed after exposure to 17β-estradiol, 17α-ethinylestradiol, and 4-t-octylphenol, which have estrogenic activity. In addition, antiandrogenic chems. or chems. without endocrine-disrupting activity did not induce changes in gsdf expression in XX or XY embryos. Thus, an increase in gsdf expression after androgen exposure was observed in XX embryos. Together, these findings indicate that gsdf expression might be useful for predicting the adverse effect of chems. on gonadal differentiation.4-tert-Octylphenol (cas: 140-66-9) were involved in the experimental procedure.
4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.Recommanded Product: 140-66-9 It has been shown to cause harm to vertebrate male reproductive systems.
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