Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. 7748-36-9, formula is C3H6O2, Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Two implementations are employed, the direct and indirect methods. Name: Oxetan-3-ol
Felts, Andrew S.;Bollinger, Katrina A.;Brassard, Christopher J.;Rodriguez, Alice L.;Morrison, Ryan D.;Scott Daniels, J.;Blobaum, Anna L.;Niswender, Colleen M.;Jones, Carrie K.;Jeffrey Conn, P.;Emmitte, Kyle A.;Lindsley, Craig W. research published 《 Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5》, the research content is summarized as follows. This letter describes the further chem. optimization of VU0424238 (auglurant), an mGlu5 NAM clin. candidate that failed in nonhuman primate (NHP) 28 day toxicol. due to accumulation of a species-specific aldehyde oxidase (AO) metabolite of the pyrimidine head group. Here, the authors excised the pyrimidine moiety, identified the min. pharmacophore, and then developed a new series of saturated ether head groups that ablated any AO contribution to metabolism Putative back-up compounds in this novel series provided increased sp3 character, uniform CYP450-mediated metabolism across species, good functional potency and high CNS penetration. Key to the optimization was a combination of matrix and iterative libraries that allowed rapid surveillance of multiple domains of the allosteric ligand.
Name: Oxetan-3-ol, Oxetan-3-ol is a useful research compound. Its molecular formula is C3H6O2 and its molecular weight is 74.08 g/mol. The purity is usually 95%.
Oxetan-3-ol is a synthetic hydroxy compound with the chemical formula C6H12O3. It is an organic solvent that can be used in reactions involving vinyl alcohol and oxetane, such as ring-opening polymerization and cationic polymerization. Oxetan-3-ol has also been shown to react with ethyl bromoacetate to form the corresponding oxetane, which can be used as a bioisostere for chloropropane, a potential replacement for chlorofluorocarbons., 7748-36-9.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts