Synthetic Route of C11H16O《Evaluation of antibacterial activity, antioxidant properties of Cynara Scolymus L. aqueous leaf and pulp extracts and their effect on streptozotocin-induced diabetic rats》 was published in 2018. The authors were EL-Ghandour, Hanan M.;Wahdan, Ola A.;El-Chaghaby, Ghadir A., and the article was included in《Journal of Chemical, Biological and Physical Sciences》. The author mentioned the following in the article:
Cynara Scolymus L. (Artichoke) is appreciated as a medicinal plant possessing health benefits. Aqueous extracts of artichoke leaf and pulp were prepared and tested for antibacterial activity against four Gram-neg. bacteria (Escherichia coli, Nisseria gonorrhoeae, pseudomonas aeruqinosa and Salmonella sp.) and five Gram-pos. bacteria (Bacillus cereus, Listeria monocytogenes, Bacillus subtilis, Streptococcus faecalis and Staphylococcus aureus). Data revealed that aqueous pulp extract had moderate antibacterial activity against tested bacteria except Salmonella sp. for which the extract did not show any inhibition activity. Whereas, the aqueous leaf extract showed better activity against tested Gram-pos. bacteria except for Bacillus cereus species. Also, leaf extract exhibited activity against tested Gram-neg. bacteria except Salmonella sp. The total antioxidant capacities of Cynara leaf and pulp aqueous extracts valued 151.15 and 63.18 ppm ascorbic acid equivalent, resp. Gas chromatog./ mass anal. ensured the existence of more than 40 bioactive compounds in the extracts Biol. experiment was conducted on streptozotocin induced diabetic rats. Diabetes is associated with inflammation and generation of excessive free radical. Erythrocyte Sedimentation Rate (ESR) and C-Reactive ProteinC – reactive protein (CRP) tests were monitored as inflammation biomarkers. Supplementation with Cynara aqueous extracts led to decreased ESR levels indicating minimization of inflammatory condition. Blood glucose and ALT levels increased significantly (p = 0.05) in diabetic group, while CRP was not affected and neg. results were obtained in all treated groups. In conclusion, the results showed that both extracts ameliorated ESR levels reflecting the fact that they improve health status by vanishing the inflammatory and oxidative stress conditions associated with hyperglycemia. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .
4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Synthetic Route of C11H16O
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