Yang, Lu;Wenzel, Thomas;Williamson, R. Thomas;Christensen, Melodie;Schafer, Wes;Welch, Christopher J. published 《Expedited Selection of NMR Chiral Solvating Agents for Determination of Enantiopurity》. The research results were published in《ACS Central Science》 in 2016.Related Products of 579-43-1 The article conveys some information:
The use of NMR chiral solvating agents (CSAs) for the anal. of enantiopurity was known for decades, but was supplanted in recent years by chromatog. enantioseparation technol. While chromatog. methods for the anal. of enantiopurity are now commonplace and easy to implement, there are still individual compounds and entire classes of analytes where enantioseparation can prove extremely difficult, notably, compounds that are chiral by virtue of very subtle differences such as isotopic substitution or small differences in alkyl chain length. NMR anal. using CSAs can often be useful for such problems, but the traditional approach to selection of an appropriate CSA and the development of an NMR-based anal. method often involves a trial-and-error approach that can be relatively slow and tedious. The authors describe a high-throughput experimentation approach to the selection of NMR CSAs that employs automation-enabled screening of prepared libraries of CSAs in a systematic fashion. This approach affords excellent results for a standard set of enantioenriched compounds, providing a valuable comparative data set for the effectiveness of CSAs for different classes of compounds The technique was successfully applied to challenging pharmaceutical development problems that are not amenable to chromatog. solutions Overall, this methodol. provides a rapid and powerful approach for studying enantiopurity that compliments and augments conventional chromatog. approaches.rel-(1R,2S)-1,2-Diphenylethane-1,2-diol (cas: 579-43-1) were involved in the experimental procedure.
rel-(1R,2S)-1,2-Diphenylethane-1,2-diol(cas: 579-43-1 Related Products of 579-43-1) has been used in the preparation of trans-methyl meso-hydrobenzoin phosphite.
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