Houston, Sevan D.;Fahrenhorst-Jones, Tyler;Xing, Hui;Chalmers, Benjamin A.;Sykes, Melissa L.;Stok, Jeanette E.;Farfan Soto, Clementina;Burns, Jed M.;Bernhardt, Paul V.;De Voss, James J.;Boyle, Glen M.;Smith, Maree T.;Tsanaktsidis, John;Savage, G. Paul;Avery, Vicky M.;Williams, Craig M. published 《The cubane paradigm in bioactive molecule discovery: further scope, limitations and the cyclooctatetraene complement》. The research results were published in《Organic & Biomolecular Chemistry》 in 2019.Application of 110-03-2 The article conveys some information:
The cubane Ph ring bioisostere paradigm was further explored in an extensive study covering a wide range of pharmaceutical and agrochem. templates, which included antibiotics (cefaclor, penicillin G) and antihistamine (diphenhydramine), a smooth muscle relaxant (alverine), an anesthetic (ketamine), an agrochem. insecticide (triflumuron), an antiparasitic (benznidazole) and an anticancer agent (tamibarotene). This investigation highlights the scope and limitations of incorporating cubane into bioactive mol. discovery, both in terms of synthetic compatibility and phys. property matching. Cubane maintained bioisosterism in the case of the Chagas disease antiparasitic benznidazole, although it was less active in the case of the anticancer agent (tamibarotenne). Application of the cyclooctatetraene (COT) (bio)motif complement was found to optimize benznidazole relative to the benzene parent, and augmented anticancer activity relative to the cubane analog in the case of tamibarotene. Like all bioisosteres, scaffolds and biomotifs, however, there are limitations (e.g. synthetic implementation), and these have been specifically highlighted herein using failed examples. A summary of all templates prepared to date by our group that were biol. evaluated strongly supports the concept that cubane is a valuable tool in bioactive mol. discovery and COT is a viable complement. To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Application of 110-03-2
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