《Certain High Production Volume Chemicals; Test Rule and Significant New Use Rule; Fourth Group of Chemicals》 was published in 2011. The article was appeared in 《Federal Register》. The authors have made some progress in their research.
EPA is proposing to issue a test rule under Toxic Substances Control Act (TSCA) section 4(a)(1)(B) to require manufacturers and processors of 23 high production volume (HPV) chem. substances to develop screening-level health, environmental, and fate data based on the potential for substantial exposures of workers and consumers to these chems. EPA is also proposing to issue simultaneously a significant new use rule (SNUR) for another 22 HPV chem. substances under tSCA section 5(a)(2). The SNUR would require persons to file a significant new use notice (SNUN) with EPA prior to manufacturing, importing, or processing any of these chem. substances for use in a consumer product or for any use, or combination of uses, that is reasonably likely to exposure 1,000 or more workers at a single corporate entity. The required notification would provide EPA with the opportunity to evaluate the intended use and, if necessary, to prohibit or limit that activity before it occurs. EPA is also soliciting comment on a number of issues with regard to both the test rule and the SNUR. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Safety of 2,5-Dimethyl-2,5-hexanediol
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts