Duvall, Bridget team published research on Bioorganic & Medicinal Chemistry in 2020 | 72824-04-5

Reference of 72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

In general, the hydroxyl group makes alcohols polar. 72824-04-5, formula is C9H17BO2, Because of hydrogen bonding, alcohols tend to have higher boiling points than comparable hydrocarbons and ethers. Reference of 72824-04-5

Duvall, Bridget;Zimmermann, Sarah C.;Gao, Run-Duo;Thomas, Ajit G.;Kalcic, Filip;Veeravalli, Vijayabhaskar;Elgogary, Amira;Rais, Rana;Rojas, Camilo;Le, Anne;Slusher, Barbara S.;Tsukamoto, Takashi research published 《 Allosteric kidney-type glutaminase (GLS) inhibitors with a mercaptoethyl linker》, the research content is summarized as follows. A series of allosteric kidney-type glutaminase (GLS) inhibitors possessing a mercaptoethyl (-SCH2CH2-) linker I [R = Ph, 2-pyridyl, 3-F3CC6H4; R1 = Ph, 2-pyridyl, 3-F3CC6H4, 4-Me2NC6H4] and II [X = CH2, S; Y = CH2, S] were synthesized in an effort to further expand the structural diversity of chemotypes derived from bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), a prototype allosteric inhibitor of GLS. BPTES analog I [R = Ph; R1 = Ph] with a mercaptoethyl linker between the two thiadiazole rings was found to potently inhibit GLS with an IC50 value of 50 nM. Interestingly, the corresponding derivative with an Pr (-CH2CH2CH2-) linker showed substantially lower inhibitory potency (IC50 = 2.3μM) while the derivative with a dimethylsulfide (-CH2SCH2-) linker showed no inhibitory activity at concentrations up to 100μM, underscoring the critical role played by the mercaptoethyl linker in the high affinity binding to the allosteric site of GLS. Addnl. mercaptoethyl-linked compounds were synthesized and tested as GLS inhibitors to further explore SAR within this scaffold including derivatives possessing a pyridazine as a replacement for one of the two thiadiazole moiety.

Reference of 72824-04-5, Allylboronic acid pinacol ester is a useful research compound. Its molecular formula is C9H17BO2 and its molecular weight is 168.04 g/mol. The purity is usually 95%.
Allylboronic acid pinacol ester is an allylation reagent that is used to produce aldehydes from ketones. It reacts with water, yielding the desired product and formaldehyde as a byproduct. The reaction proceeds through a sequence of steps, in which the boronate ester first reacts with water to form an allylboronate ion and hydrogen gas. This intermediate then reacts with potassium t-butoxide to produce the desired allyl alcohol and potassium borohydride. Finally, the palladium complex catalyst reduces the carbonyl group of the starting material, converting it into an aldehyde. Allylboronic acid pinacol ester is commercially available as a white solid, but can also be synthesized from 2-chloro-5-pinacolylborane (pinacol) in high yield using catalytic cross coupling reactions., 72824-04-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts