Dryzhakov, Marian;Moran, Joseph published 《Autocatalytic Friedel-Crafts Reactions of Tertiary Aliphatic Fluorides Initiated by B(C6F5)3·H2O》. The research results were published in《ACS Catalysis》 in 2016.Name: 3,7-Dimethyloctan-3-ol The article conveys some information:
The C-F bond is the strongest single bond to carbon, constituting an intrinsic challenge for selective catalytic activation in the presence of other functional groups. Existing methods for the activation of tertiary aliphatic fluorides involve stoichiometric abstraction with fluorophilic Lewis acids or by Lewis-acid-catalyzed trapping with Si reagents. Herein, we describe a B(C6F5)3·H2O-catalyzed Friedel-Crafts reaction of tertiary alkyl fluorides that proceeds rapidly at room temperature without trapping reagents. The method is completely selective for F– over traditionally better leaving groups and displays an autocatalytic kinetic profile. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .
3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Name: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.
Reference:
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