Dong, Kaiwu;Sang, Rui;Liu, Jie;Razzaq, Rauf;Franke, Robert;Jackstell, Ralf;Beller, Matthias published 《Palladium-Catalyzed Carbonylation of sec- and tert-Alcohols》 in 2017. The article was appeared in 《Angewandte Chemie, International Edition》. They have made some progress in their research.Safety of 2,5-Dimethyl-2,5-hexanediol The article mentions the following:
A general palladium-catalyzed synthesis of linear esters directly from sec- and tert-alcs. is described. Compared to the classic Koch-Haaf reaction, which leads to branched products, this new transformation gives the corresponding linear esters in high yields and selectivity. Key for this protocol is the use of an advanced palladium catalyst system with pytbpx as the ligand. A variety of aliphatic and benzylic alcs. can be directly used and the catalyst efficiency for the benchmark reaction is outstanding (turnover number up to 89 000). To complete the study, the researchers used 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Safety of 2,5-Dimethyl-2,5-hexanediol
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts