COA of Formula: C8H12ClNO2《Effect of pyridoxal phosphate on toxicity and antitumor activity of mitomycin C and 4-deoxypyridoxine hydrochloride in rats. Preliminary observations》 was published in 1966. The authors were Fujimoto, Shigeru, and the article was included in《Cancer Chemotherapy Rept.》. The author mentioned the following in the article:
In rats bearing ascites hepatoma, combined therapy with mitomycin C and vitamin B6 arrested leukopenia, but failed to alleviate liver dysfunction and anemia. The growth of subcutaneous tumors was not stimulated by vitamin B6. Tumor growth was inhibited for 2 weeks after administration of 4-deoxypyridoxine-HCl, an antagonist of vitamin B6, to rats fed a diet free of vitamin B6. The administration of vitamin B6 did not lessen the effect of mitomycin C on subcutaneous tumors in rats. Vitamin B6 might counteract leukopenia, a side effect of antitumor agents, by an improvement in metabolism of proteins. And 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) was used in the research process.
5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 COA of Formula: C8H12ClNO2) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. DOP inhibits sphingosine-1-phosphate (S1P) lyase and reduces cyclic stretch-induced apoptosis in alveolar epithelial MLE-12 cells.
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