Baldwin, Austin K.;Corsi, Steven R.;Stefaniak, Owen M.;Loken, Luke C.;Villeneuve, Daniel L.;Ankley, Gerald T.;Blackwell, Brett R.;Lenaker, Peter L.;Nott, Michelle A.;Mills, Marc A. published 《Risk-Based Prioritization of Organic Chemicals and Locations of Ecological Concern in Sediment From Great Lakes Tributaries》. The research results were published in《Environmental Toxicology and Chemistry》 in 2022.COA of Formula: C14H22O The article conveys some information:
With improved anal. techniques, environmental monitoring studies are increasingly able to report the occurrence of tens or hundreds of chems. per site, making it difficult to identify the most relevant chems. from a biol. standpoint. For the present study, organic chem. occurrence was examined, individually and as mixtures, in the context of potential biol. effects. Sediment was collected at 71 Great Lakes (USA/Canada) tributary sites and analyzed for 87 chems. Multiple risk-based lines of evidence were used to prioritize chems. and locations, including comparing sediment concentrations and estimated porewater concentrations with established whole-organism benchmarks (i.e., sediment and water quality criteria and screening values) and with high-throughput toxicity screening data from the US Environmental Protection Agency′s ToxCast database, estimating additive effects of chem. mixtures on common ToxCast endpoints, and estimating toxic equivalencies for mixtures of alkylphenols and polycyclic aromatic hydrocarbons (PAHs). This multiple-lines-of-evidence approach enabled the screening of more chems., mitigated the uncertainties of individual approaches, and strengthened common conclusions. Collectively, at least one benchmark/screening value was exceeded for 54 of the 87 chems., with exceedances observed at all 71 of the monitoring sites. Chems. with the greatest potential for biol. effects, both individually and as mixture components, were bisphenol A, 4-nonylphenol, indole, carbazole, and several PAHs. Potential adverse outcomes based on ToxCast gene targets and putative adverse outcome pathways relevant to individual chems. and chem. mixtures included tumors, skewed sex ratios, reproductive dysfunction, hepatic steatosis, and early mortality, among others. The results provide a screening-level prioritization of chems. with the greatest potential for adverse biol. effects and an indication of sites where they are most likely to occur. To complete the study, the researchers used 4-tert-Octylphenol (cas: 140-66-9) .
4-tert-Octylphenol(cas: 140-66-9) is a common environmental pollutant showing weak estrogenic effects.COA of Formula: C14H22O It has been shown to cause harm to vertebrate male reproductive systems.
Reference:
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