Palvoelgyi, Adam Mark;Smith, Jakob;Schnuerch, Michael;Bica-Schroeder, Katharina published 《Counterion-Enhanced Pd/Enamine Catalysis: Direct Asymmetric α-Allylation of Aldehydes with Allylic Alcohols by Chiral Amines and Achiral or Racemic Phosphoric Acids》. The research results were published in《Journal of Organic Chemistry》 in 2021.Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:
We report a straightforward and efficient Pd/enamine catalytic procedure for the direct asym. α-allylation of branched aldehydes. The use of simple chiral amines and easily prepared achiral or racemic phosphoric acids, together with a suitable Pd-source resulted in a highly active and enantioselective catalyst system for the allylation of various α-branched aldehydes with different allylic alcs. The reported procedure could provide an easy access to both product antipodes. Furthermore, two possible orthogonal derivatizations of the enantioenriched aldehydes were performed without any decrease in enantioselectivity. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.
Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts