Gurkan-Alp, A. Selen;Mumcuoglu, Mine;Andac, Cenk A.;Dayanc, Emre;Cetin-Atalay, Rengul;Buyukbingol, Erdem published 《Synthesis, anticancer activities and molecular modeling studies of novel indole retinoid derivatives》. The research results were published in《European Journal of Medicinal Chemistry》 in 2012.HPLC of Formula: 110-03-2 The article conveys some information:
In this study, novel (E)-3-(5-substituted-1H-indol-3-yl)-1-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-en-1-one derivatives were synthesized and their anticancer effects were determined in vitro. Novel indole retinoid compounds have anti-proliferative capacity in liver, breast, and colon cancer cell lines. This anti-proliferative effect was further analyzed in breast cancer cell line panel by using the most potent compound The latter can inhibit proliferation at very low IC50 concentrations in all of the breast cancer cell lines. Here, we present some evidence on apoptotic termination of cancer cell proliferation which may be primarily driven by the inhibition of RXRα and, to a lesser extent, RXRγ. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.
2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.HPLC of Formula: 110-03-2
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