Name: 4-tert-Amylphenol《Risk-based high-throughput chemical screening and prioritization using exposure models and in vitro bioactivity assays》 was published in 2015. The authors were Shin, Hyeong-Moo;Ernstoff, Alexi;Arnot, Jon A.;Wetmore, Barbara A.;Csiszar, Susan A.;Fantke, Peter;Zhang, Xianming;McKone, Thomas E.;Jolliet, Olivier;Bennett, Deborah H., and the article was included in《Environmental Science & Technology》. The author mentioned the following in the article:
The authors present a risk-based high-throughput screening (HTS) method to identify chems. for potential health concerns or for which addnl. information is needed. The method is applied to 180 organic chems. as a case study. The authors first obtain information on how the chem. is used and identify relevant use scenarios (e.g., dermal application, indoor emissions). For each chem. and use scenario, exposure models are then used to calculate a chem. intake fraction, or a product intake fraction, accounting for chem. properties and the exposed population. The authors then combine these intake fractions with use scenario-specific estimates of chem. quantity to calculate daily intake rates (iR; mg/kg/day). These intake rates are compared to oral equivalent doses (OED; mg/kg/day), calculated from a suite of ToxCast in vitro bioactivity assays using in vitro-to-in vivo extrapolation and reverse dosimetry. Bioactivity quotients (BQs) are calculated as iR/OED to obtain estimates of potential impact associated with each relevant use scenario. Of the 180 chems. considered, 38 had maximum iRs exceeding min. OEDs (i.e., BQs >1). For most of these compounds, exposures are associated with direct intake, food/oral contact, or dermal exposure. The method provides high-throughput estimates of exposure and important input for decision makers to identify chems. of concern for further evaluation with addnl. information or more refined models. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.
4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Name: 4-tert-Amylphenol
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