Charvin, Delphine team published research on Journal of Medicinal Chemistry in 2017 | 141699-55-0

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Related Products of 141699-55-0

Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 141699-55-0, formula is C8H15NO3, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Related Products of 141699-55-0

Charvin, Delphine;Pomel, Vincent;Ortiz, Millan;Frauli, Melanie;Scheffler, Sophie;Steinberg, Edith;Baron, Luc;Deshons, Laurene;Rudigier, Rachel;Thiarc, Delphine;Morice, Christophe;Manteau, Baptiste;Mayer, Stanislas;Graham, Danielle;Giethlen, Bruno;Brugger, Nadia;Hedou, Gael;Conquet, Francois;Schann, Stephan research published 《 Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4》, the research content is summarized as follows. The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson’s disease (PD). However, since the discovery of its therapeutic potential, no ligand has been successfully developed enough to be tested in the clinic. In the present paper, we report for the first time the medicinal chem. efforts conducted around the pharmacol. tool (-)-PHCCC. This work led to the identification of compound 40, a potent and selective mGluR4 pos. allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclin. rodent models of PD motor symptoms after i.p. administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. Moreover, we also describe the identification of compound 60 a close analog of compound 40 with improved pharmacokinetic profile after oral administration. On the basis of its favorable and unique preclin. profile, compound 60 (PXT002331, now foliglurax) was nominated as a candidate for clin. development.

141699-55-0, Tert-butyl 3-hydroxyazetidine-1-carboxylate is a useful research compound. Its molecular formula is C8H15NO3 and its molecular weight is 173.21 g/mol. The purity is usually 95%.

Tert-butyl 3-hydroxyazetidine-1-carboxylate has been shown to be a good substrate for the preparation of N-protected amino alcohols and amines by the process of reductive amination. In this synthesis, tert-butyl azetidinium chloride is used as a catalyst in the reaction with sodium hydroxide. The tert-butyl group can be removed using ammonium hydroxide in the presence of a base such as triethylamine. This reaction can be performed on a large scale, making it useful in the manufacture of pharmaceuticals. The efficiency and solubility of this process make it suitable for use as an introduction to other processes involving N-protected amino alcohols or amines., Related Products of 141699-55-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts