In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. 24034-73-9, formula is C20H34O, Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble. COA of Formula: C20H34O
Calzada, Fernando;Ramirez-Santos, Jesica;Valdes, Miguel;Garcia-Hernandez, Normand;Pina-Jimenez, Emmanuel;Ordonez-Razo, Rosa Maria research published 《 Evaluation of Acute Oral Toxicity, Brine Shrimp Lethality, and Antilymphoma Activity of Geranylgeraniol and Annona macroprophyllata Leaf Extracts》, the research content is summarized as follows. In this study, we investigated the acute oral toxicity, brine shrimp lethality, and the antilymphoma activity of geranylgeraniol and the ethanolic and petroleum ether extracts of Annona macroprophyllata Donn.Sm., Annonaceae, leaves. Leaves were extracted by maceration with ethanol or petroleum ether. In acute oral toxicity anal., the ethanolic extract had a LD50 of 1587 mg/kg, while the petroleum ether extract had an LD50 of > 3000 mg/kg. This indicated that the petroleum ether extract may be less harmful than the ethanolic extract Furthermore, the petroleum ether extract showed low acute toxicity (category 5), significant brine shrimp lethality, and a high antilymphoma activity. Therefore, petroleum ether extract was purified by preparative thin layer chromatog. to yield geranylgeraniol. The results showed that geranylgeraniol (LC50 = 1.00μg/mL) was more potent than methotrexate (LC50 24.66μg/mL), a known chemotherapy drug. Addnl., geranylgeraniol showed high antilymphoma activity in Balb/c mice injected i.p. with 1 x 106 U-937 of human leukemic monocyte lymphoma cells, resulting in 50% effective inhibitory concentration (EC50) values of 4.38 mg/kg and 3.66 mg/kg for male and female mice, resp. The antilymphoma activity of geranylgeraniol was similar to that of methotrexate (EC50 = 1.07 mg/kg and 1.33 mg/kg, resp.). These findings suggest that geranylgeraniol may serve as a potential natural compound for the treatment of lymphoma.
24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.
Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
, COA of Formula: C20H34O
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts