Simple alcohols are found widely in nature. Ethanol is the most prominent because it is the product of fermentation, a major energy-producing pathway. 24034-73-9, formula is C20H34O, Other simple alcohols, chiefly fusel alcohols, are formed in only trace amounts. More complex alcohols however are pervasive, as manifested in sugars, some amino acids, and fatty acids. , Related Products of 24034-73-9
Batista, Mateus Alves;de Lima Teixeira dos Santos, Abrahao Victor Tavares;do Nascimento, Aline Lopes;Moreira, Luiz Fernando;Souza, Indira Ramos Senna;da Silva, Heitor Ribeiro;Pereira, Arlindo Cesar Matias;da Silva Hage-Melim, Lorane Izabel;Carvalho, Jose Carlos Tavares research published 《 Potential of the Compounds from Bixa orellana Purified Annatto Oil and Its Granules (Chronic) against Dyslipidemia and Inflammatory Diseases: In Silico Studies with Geranylgeraniol and Tocotrienols》, the research content is summarized as follows. Some significant compounds present in annatto are geranylgeraniol and tocotrienols. These compounds have beneficial effects against hyperlipidemia and chronic diseases, where oxidative stress and inflammation are present, but the exact mechanism of action of such activities is still a subject of research. This study aimed to evaluate possible mechanisms of action that could be underlying the activities of these mols. For this, in silico approaches such as ligand topol. (PASS and SEA servers) and mol. docking with the software GOLD were used. Addnl., we screened some pharmacokinetic and toxicol. parameters using the servers PreADMET, SwissADME, and ProTox-II. The results corroborate the antidyslipidemia and anti-inflammatory activities of geranylgeraniol and tocotrienols. Notably, some new mechanisms of action were predicted to be potentially underlying the activities of these compounds, including inhibition of squalene monooxygenase, lanosterol synthase, and phospholipase A2. These results give new insight into new mechanisms of action involved in these mols. from annatto and Chronic.
Related Products of 24034-73-9, Geranylgeraniol is a diterpenoid that is hexadeca-2,6,10,14-tetraene substituted by methyl groups at positions 3, 7, 11 and 15 and a hydroxy group at position 1. It has a role as a plant metabolite, a volatile oil component and an antileishmanial agent. It is a diterpenoid and a polyprenol.
Geranylgeraniol, a precursor to geranylgeranylpyrophosphate, is an intermediate in the mevalonate pathway. Geranylgeraniol has been shown to prevent bone re-absorption, inhibition of osteoclast formation, and kinase activation in vitro. When working with statins, Geranylgeraniol can reduce the toxicity without inhibiting the cholesterol-producing effects. Geranylgeraniol has been documented to counteract the effects of fluvastatin by inhibiting activation of caspase-1 and production of IL-1. Additionally Geranylgeraniol has been found to induce apoptosis in HL-60 cells.
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Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts