Month: April 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF, published in 2013-04-19, which mentions a compound: 16588-26-4, Name is 3-Bromo-4-chloronitrobenzene, Molecular C6H3BrClNO2, Quality Control of 3-Bromo-4-chloronitrobenzene.

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Efficient ligand-free copper-catalyzed N-arylation of amides with aryl halides in water, published in 2011-03-16, which mentions a compound: 7661-33-8, mainly applied to copper catalyzed arylation cross coupling amide aryl iodide, Recommanded Product: 1-(4-Chlorophenyl)pyrrolidin-2-one.

A convenient and efficient protocol has been developed for the cross-coupling of amides and aryl iodides using a ligand-free copper(I) oxide catalyst in water. A variety of amide derivatives afforded the corresponding N-arylated products in moderate to good yields (up to 88%).

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Synthesis and transition metal complexes of 1,1′-bis(diphenylethynylphosphino)ferrocene.Reference of Dichloro(1,5-cyclooctadiene)platinum(II).

The new ferrocene based bisphosphine [Fe{C5H4P(CCPh)2}2] (1) was synthesized in 82% yield by the treatment of bis(dichlorophosphino)ferrocene [Fe(C5H4PCl2)2] with four equivalent of lithium phenylacetylide. The reactions of 1 with aqueous H2O2, elemental sulfur or selenium afforded bis(chalcogenide) derivatives, [Fe{C5H4P(E)(CCPh)2}2] (2 E = O, 3 E = S, 4 E = Se). The reaction of 1 with [M(NC5H11)2(CO)4] (M = Mo, W), [RuCp(PPh3)2Cl] and [M(COD)Cl2] (M = Pd, Pt) resulted in the formation of the resp. chelate complexes, [Fe{C5H4P(CCPh)2}2{M(CO)4}] (5 M = Mo, 6 M = W), [Fe{C5H4P(CCPh)2}2{RuCp(Cl)}] (8) and [Fe{C5H4P(CCPh)2}2{MCl2}] (9 M = Pd, 10 M = Pt), whereas the reaction of 1 with [Ru(η6-p-cymene)Cl2]2 and [AuCl(SMe2)] yielded the corresponding bimetallic complexes [Fe{C5H4P(CCPh)2}2{RuCl2(η6-p-cymene)}2] (7) and [Fe{C5H4P(CCPh)2}2{AuCl}2] (15). The reactions between 1 and CuX in equimolar ratios also yielded binuclear complexes, [Fe{C5H4P(CCPh)2}2{CuX}2] (11 X = Cl, 12 X = Br, 13 X = I), whereas [Cu(CH3CN)4]BF4 yielded the cationic complex [(Fe{C5H4P(CCPh)2}2)2Cu]BF4 (14). All the compounds were characterized by spectroscopic methods and the structures of complexes 1, 5, 6, 8, 10, 13 and 14 were confirmed by single crystal x-ray diffraction studies.

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Category: alcohols-buliding-blocks. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Cyclometalated Platinum(II) Complexes with Mesoionic Dibenzofuranyl-1,2,3-triazol-4-ylidene Ligands: Synthesis, Characterization and Photophysical Properties. Author is Soellner, Johannes; Strassner, Thomas.

Platinum(II) complexes with mesoionic C-C*-cyclometalating 1,2,3-triazolylidene ligands are highly efficient phosphorescent emitters. Herein we report a series of this type bearing dibenzofuranyl-substituted carbenes along with different β-diketonate auxiliary ligands. They show luminescence in the green region of the visible spectrum and quantum yields of up to 78% at room temperature The proposed mol. structures were verified by NMR spectroscopy and x-ray diffraction experiments which prove the formation of the mesoionic carbene. Addnl., DFT calculations and cyclic voltammetry measurements were used to rationalize the observed photophys. properties of the reported complexes.

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Trusov, S. N.; Sevbo, D. P.; Veretennikova, N. L.; Mikhailitsyn, F. S. published an article about the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4,SMILESS:BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl ).Quality Control of 3-Bromo-4-chloronitrobenzene. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:16588-26-4) through the article.

Some title derivatives were synthesized and tested for trichinellocidal activity. N-[3-bromophenyl-4-(5-chloroquinolinoxy)]-3,5-dibromosalicylamide exhibited trichinellocidal activity (in mice infected with decapsulated Trichinella spiralis) that was close to that of mebendazole.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Rhodium(III)-Catalyzed C-H Vinylation of Arenes: Access to Functionalized Styrenes, the main research direction is vinyltriethoxysilane arene rhodium catalyst regioselective oxidative vinylation green chem; vinylarene preparation; acetanilide vinyltriethoxysilane rhodium catalyst regioselective oxidative vinylation palladium heterocyclization; acylindole preparation green chem.Formula: C10H10ClNO.

An effective method were developed for Rh(III)-catalyzed direct vinylation of arenes to give functionalized styrenes, using vinyltriethoxysilane as a convenient and inexpensive vinyl source. A wide variety of substrates, including 1-aryl-2-pyrrolidinones, anilines, benzamides and ketones were compatible with this reaction. Moreover, this method can be applied to the two-step synthesis of functionalized indoles. Mechanistic investigation reveals that the reaction probably proceeds through an oxidative Heck/desilylation pathway.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Oxidation of organic compounds. XCIV. Synthesis of 3,5-dicyanopyridine by the oxidative ammonolysis of 3,5-butidine, published in 1973, which mentions a compound: 1195-58-0, mainly applied to lutidine ammoxidation; pyridinedicarbonitrile, Product Details of 1195-58-0.

Ammoxidation of 3,5-lutidine (I) using 1:9:17 I-O-NH3 at 350° in the presence of fused vanadium oxide-titanium oxide with a 0.5 sec contact time gave 40% 3,5-pyridinedicarbonitrile (II) and 5-methyl-3-pyridinecarbonitrile. Hydrolysis of II in aqueous NaOH gave 3,5-pyridinedicarboxylic acid.

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Puttock, Emma V.; Sturala, Jiri; Kistemaker, Jos C. M.; Williams, J. A. Gareth published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Reference of Dichloro(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

Five Pt(II) complexes are described in which the metal ion is bound to anionic N N N-coordinating ligands. The central, deprotonated N atom is derived from an imide Ar-C(:O)-NH-C(:O)-Ar {PtL1-2Cl; Ar = pyridine or pyrimidine}, an amide py-C(:O)-NH-CH2-py {PtL3Cl}, or a hydrazide py-C(:O)-NH-N:CH-py {PtL4Cl}. The imide complexes PtL1-2Cl show no significant emission in solution but are modestly bright green/yellow phosphors in the solid state. PtL3Cl is weakly phosphorescent. PtL4Cl is formed as a mixture of isomers, bound through either the amido or imino nitrogen, the latter converting to the former upon absorption of light. Remarkably, the imino form displays fluorescence in solution, λ0,0=535 nm, whereas the amido shows phosphorescence, λ0,0=624 nm, τ=440 ns. It is highly unusual for two isomeric compounds to display emission from states of different spin multiplicity. The amido-bound PtL4Cl can act as a bidentate O N-coordinating ligand, demonstrated by the formation of bimetallic complexes with iridium(III) or ruthenium(II).

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Formula: C10H10ClNO. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology. Author is Chang, Raymond K.; Clairmont, Brice P.; Lin, Shirley; MacArthur, Amy H. Roy.

A copper iodide-catalyzed concurrent tandem catalytic (CTC) methodol. has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the N-aryl secondary or tertiary amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol% CuI, 60 mol% N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200° after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts Mechanistic studies are consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

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Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 651780-02-8, is researched, Molecular C12H13BrN2O2, about Indazoles: Regioselective Protection and Subsequent Amine Coupling Reactions, the main research direction is indazole regioselective protection Buchwald amine coupling.Application of 651780-02-8.

Indazoles are unselectively protected under strongly basic conditions to give a mixture at positions N-1 and N-2. Under mildly acidic conditions, regioselective protection at N-2 takes place. Thermodn. conditions lead to regioselective protection at N-1. This trend applies to various substituted indazoles. Protected 5-bromoindazoles participate in Buchwald reactions with a range of amines to generate novel derivatives

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