Month: April 2022

Product Details of 16588-26-4. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about L-(-)-Quebrachitol as a Ligand for Selective Copper(0)-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles. Author is Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Sun, Wenjiao; Wu, Ying; Chen, Guoliang.

L-(-)-Quebrachitol (QCT) was found as a ligand of copper powder for selective N-arylation of nitrogen-containing heterocycles with aryl halides. Furthermore, another potential catalytic system (copper powder/QCT/t-BuOK) was successfully adapted to unactivated aryl chlorides.

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Electric Literature of C10H10ClNO. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the ring contraction and deformylative functionalization of piperidine derivatives. Author is Wang, Fang; Zhang, Xinying; He, Yan; Fan, Xuesen.

In this paper, a selective synthesis of pyrrolidin-2-ones and 3-iodopyrroles via the cascade reactions of N-substituted piperidines is presented [e.g., N-phenylpiperidine → N-phenyl-2-pyrrolidinone (58%) in presence of Cu(OAc)2/KI/Oxone/O2 in MeCN and N-phenylpiperidine → 3-iodo-N-phenylpyrrole (65%) in presence of Cu(OAc)2/I2/DMAP/O2 in MeCN]. Mechanistically, the formation of pyrrolidin-2-ones involves a domino process including the in situ formation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation and ipso-oxidation On the other hand, 3-iodopyrroles are believed to be formed via the initial generation of pyrrolidine-2-carbaldehyde followed by carboxylic acid formation, decarboxylation, dehydrogenation, iodination and aromatization. Interestingly, either pyrrolidin-2-ones or 3-iodopyrroles could be obtained selectively from the same substrates, and the selectivity was easily tuned by using a specific oxidant and additive.

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Category: alcohols-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Pyridine-3,5-dicarbonitrile, is researched, Molecular C7H3N3, CAS is 1195-58-0, about HMO [Hueckel molecular orbital] calculation and the reactivity of quinolinecarbonitriles and isoquinolinecarbonitriles with nucleophilic reagents.

Simple Hueckel MO calculations were carried out to explain the fact that the Grignard reagents attack the CN group of 2- and 4-quinolinecarbonitriles and 1- and 3-isoquinolinecarbonitriles, whereas the ring is attacked in the case of 3-quinolinecarbonitrile and 4-isoquinolinecarbonitrile. These facts could be explained by the reactivity indexes obtained with the following parameters: α + 0.5β for the Coulomg integral of N in the ring, α + 1.1β for the Coulomb integral of N of the cyano group, and 1.4β for resonance integral of the cyano group. The νCN absorption could be correlated with the π-bond order of the cyano group and the chem. shifts of H with the π-electron density (qr) by the equation: δ = 19.64 – 12.20qr. 1-Propionylisoquinoline, b5 125°, was prepared

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Synthetic Route of C8H12Cl2Pt. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Synthesis, Coordination and Electrochemistry of a Ferrocenyl-Tagged Aminobisphosphane Ligand.

Group 10 element diphosphine square planar complexes [FcN(CH2PPh2)2MY2] (Fc = ferrocenyl; M = Ni, Pd, Pt; Y = Cl, Br), Group 11 tetraphosphine tetrahedral complexes [[FcN(CH2PPh2)2]2M]X (M = Cu, Ag, Au; X = BF4, SbF6) and gold binuclear complexes [FcN(CH2PPh2AuCl)2], [FcN(CH2PPh2)2Au]2[SbF6]2 were prepared and examined for their redox activity. Introducing a ferrocene moiety into a mol. results in the incorporation of a metal center and a redox active moiety. The ligand FcN(CH2PPh2)2 (1) was prepared by alkylation of ferrocenamine FcNH2 with hydroxymethylphosphine HOCH2PPh2 and converted to diselenide FcN(CH2P(Se)Ph2)2 (1-Se) for crystallog. identification. Furthermore, a pair of open and cyclic digold(I) complexes containing bis-phosphane 1 as a P,P-bridging ligand, were isolated. Ligand 1, the corresponding phosphane selenide 1-Se and all complexes (except for the poorly soluble [(μ(P,P’)-1)2Au2][SbF6] and unstable [Ag(1-κ2P,P’)2][SbF6]) were further analyzed by cyclic voltammetry.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sheng, Yao; Wang, Xueguang; Yue, Shengnan; Cheng, Gonglin; Zou, Xiujing; Lu, Xionggang researched the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4 ).Computed Properties of C6H3BrClNO2.They published the article 《In Situ Synthesized Silica-Supported Co@N-Doped Carbon as Highly Efficient and Reusable Catalysts for Selective Reduction of Halogenated Nitroaromatics》 about this compound( cas:16588-26-4 ) in ChemCatChem. Keywords: aromatic amine preparation chemoselective; nitrobenzene reduction cobalt catalyst. We’ll tell you more about this compound (cas:16588-26-4).

Silica-supported Co@N-doped carbon (Co@CN/SiO2) catalysts were first prepared by a one-step impregnation with a mixed solution of cobalt nitrate, glucose and urea, followed by in situ carbonization and reduction The Co@CN/SiO2 catalysts were investigated for the selective reduction of nitro aromatics RNO2 (R = Ph, 4,5-dichloro-2-nitroaniline, 2-chloro-3-nitropyridine, etc.) to the corresponding anilines RNH2 using hydrazine hydrate. The Co@CN/SiO2-500 carbonized at 500°C exhibited the highest catalytic activity and excellent stability without any decay of activity after 6 cycles for the reduction of nitrobenzene. Both metallic Co atoms and Co-N species formed in the Co@CN/SiO2 catalysts were active, but the Co-N species were dominant active sites. The high activities of the Co@CN/SiO2 catalysts were attributed to the synergistic effect between the Co and N atoms, promoting heterolytic cleavage of hydrazine to form H+/H- pairs. Representative examples demonstrated that the Co@CN/SiO2-500 could completely transform various halogen-substituted nitro aromatics to the corresponding halogenated anilines with high TOFs and selectivity of >99.5%.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 12080-32-9, is researched, SMILESS is C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-], Molecular C8H12Cl2PtJournal, ChemPhotoChem called Mesoionic 1,2,3-Triazolo[1,5-a]pyridine-3-ylidenes in Phosphorescent Platinum(II) Complexes, Author is Soellner, Johannes; Strassner, Thomas, the main research direction is crystal structure mol triazolopyridinylidene platinum diketone complex optimized DFT; uv vis photoluminescence phosphorescence triazolopyridinylidene platinum diketone complex redox.SDS of cas: 12080-32-9.

Mesoionic carbene ligands based on 1,2,3-triazole platforms can be used in cyclometalated platinum(II) complexes to achieve an efficient phosphorescence even at room temperature In this report, 1,2,3-triazolo[1,5-a]pyridine-3-ylidenes are employed in such mols. along with β-diketonates with varying steric demand. For full structural characterization, NMR spectroscopy and XRD experiments were employed. The photophys. properties were studied in solid poly(Me methacrylate) (PMMA) matrixes, as well as dichloromethane solutions In PMMA, the synthesized complexes show quantum yields of 47-54% with emission bands in the yellow region of the visible spectrum. Cyclic voltammetry measurements along with DFT calculations helped to assign the nature of the observed emissions.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Bioorganic & Medicinal Chemistry Letters called GDC-0449-A potent inhibitor of the hedgehog pathway. [Erratum to document cited in CA151:550392], Author is Robarge, Kirk D.; Brunton, Shirley A.; Castanedo, Georgette M.; Cui, Yong; Dina, Michael S.; Goldsmith, Richard; Gould, Stephen E.; Guichert, Oivin; Gunzner, Janet L.; Halladay, Jason; Jia, Wei; Khojasteh, Cyrus; Koehler, Michael F. T.; Kotkow, Karen; La, Hank; LaLonde, Rebecca L.; Lau, Kevin; Lee, Leslie; Marshall, Derek; Marsters, James C.; Murray, Lesley J.; Qian, Changgeng; Rubin, Lee L.; Salphati, Laurent; Stanley, Mark S.; Stibbard, John H. A.; Sutherlin, Daniel P.; Ubhayaker, Savita; Wang, Shumei; Wong, Susan; Xie, Minli, which mentions a compound: 16588-26-4, SMILESS is BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl, Molecular C6H3BrClNO2, Recommanded Product: 16588-26-4.

On page 1, lines 59 -62 are incorrect; the correct versions of the lines are given. On page 5 lines 220-225 are incorrect; the correct versions of the lines are given. In addition, References 25, citing K Sasai et al., (2006) and 26, citing JT Romer et al., (2004), were erroneous omitted.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 651780-02-8, is researched, SMILESS is CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12, Molecular C12H13BrN2O2Journal, Article, Research Support, N.I.H., Extramural, Organic Letters called Thioetherification via Photoredox/Nickel Dual Catalysis, Author is Jouffroy, Matthieu; Kelly, Christopher B.; Molander, Gary A., the main research direction is thioether aryl heteroaryl preparation; aryl heteroaryl bromide thioetherification thiol hypervalent alkylsilicate nickel photoredox.HPLC of Formula: 651780-02-8.

Hypervalent alkylsilicates represent new and readily accessible precursors for the generation of alkyl radicals under photoredox conditions. Alkyl radicals generated from such silicates serve as effective hydrogen atom abstractors from thiols, furnishing thiyl radicals. The reactive sulfur species generated in this manner can be funneled into a nickel-mediated cross-coupling cycle employing aromatic bromides to furnish thioethers. The serendipitous discovery of this reaction and its utilization for the thioetherification of various aryl and heteroaryl bromides with a diverse array of thiols are described. The S-H selective H atom abstraction event enables a wide range of functional groups, including those bearing protic moieties, to be tolerated.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《On cyclic intermediates in substitution reactions. VII. The alkaline solvolysis of some N-aryl-4-bromobutanamides》. Authors are Heine, Harold W.; Love, Peter; Bove, John L..The article about the compound:1-(4-Chlorophenyl)pyrrolidin-2-onecas:7661-33-8,SMILESS:O=C1N(C2=CC=C(Cl)C=C2)CCC1).Electric Literature of C10H10ClNO. Through the article, more information about this compound (cas:7661-33-8) is conveyed.

cf. C.A. 49, 1556b. The rates of the solvolysis of 3 N-aryl-4-bromobutanamides have been studied in MeOH. The rates of the reaction as determined by the measurement of the release of bromide ion are 1st order with respect to MeO-. The reaction products are the corresponding pyrrolidones. These results are discussed in terms of a mechanism involving the formation and conversion of a bromoamido ion to a pyrrolidone. SOCl2 (20 cc.) added dropwise to 37.1 g. Br(CH2)3CO2H, the mixture held 2 days at room temperature, the excess SOCl2 removed in vacuo, and the residue distilled gave a distillate, b31 88-90°, nD201.4899; a 37.1-g. sample of the distillate added dropwise with stirring to 37.2 g. PhNH2 in 500 cc. CHCl3, the mixture stirred 15 min., the precipitate filtered and washed with CHCl3, the combined filtrate and washing concentrated in vacuo, and the crude residue dissolved in ligroine, b. 65-110°, cooled, and then chilled to -78° gave 38% Br(CH2)3CONHPH (I), m. 75-6°. In the same manner except with a reaction time of 4 hrs. was prepared the p-Me derivative (II) of I, m. 90-1° (from petr. ether), in 63.2% yield. The p-Cl derivative (III) of I, m. 100-1° (from petr. ether), was prepared with a reaction time of 2 hrs. in 69.2% yield. A solution (100 cc.) 0.05M in NaOMe and 0.05M in III kept at 22.9° until all bromide ion had been released, the MeOH evaporated in vacuo, the residue washed with H2O, and the residue dried at 50° and recrystallized from petr. ether (b. 30-60°) gave 0.940 g. 1-(p-chlorophenyl)pyrrolidone (IV), m. 95-7°. The average rate constants of the alk. solvolyses determined at 22.90° were: III 5.65, I 1.80, and II 1.03 × 10 l./min./mole.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Platinum(II) complexes containing hydrazide-based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents.Application of 12080-32-9.

Four new N,N-bis(diphenylphosphino)amine ligands (amine = 1-amino-4-methylpiperazine (L1), N-aminophthalimide (L2), 4-aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using IR and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single-crystal x-ray diffraction techniques. The antitumor activities of the synthesized complexes determined using MTT assay on MDA-MB-231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose- and time-dependent manner (e.g. at a complex concentration of 100 μg ml-1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1-C4, resp.). Theor. approaches were also used to investigate the energy and the nature of metal-ligand and metal-chlorine interactions in the complexes, which could explain their biol. activities. The interaction between ligand and Pt is stronger in C2, while the Pt-Cl interaction is weaker in this complex in comparison with the other complexes.

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