What unique challenges do researchers face in 651780-02-8

Although many compounds look similar to this compound(651780-02-8)SDS of cas: 651780-02-8, numerous studies have shown that this compound(SMILES:CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

SDS of cas: 651780-02-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate, is researched, Molecular C12H13BrN2O2, CAS is 651780-02-8, about Deprotection of N-tert-Butoxycarbonyl (Boc) Protected Functionalized Heteroarenes via Addition-Elimination with 3-Methoxypropylamine. Author is Gulledge, Zachary Z.; Carrick, Jesse D..

Continued pursuit of functionalized soft-N-donor complexant scaffolds with favorable solubility and kinetics profiles applicable for the separation of the trivalent minor actinides from the lanthanides has attracted significant interest over the last three decades. Recent work from this laboratory resulted in the production of various N-Boc protected [1,2,4]triazinyl-pyridin-2-yl indole Lewis basic procomplexants which necessitated the removal of the indole N-Boc protecting group prior to evaluation of complexant efficacy in separations assays. Traditional deprotection strategies involving trifluoroacetic and other protic and Lewis acids proved unsuccessful in removal of the recalcitrant indole-N-Boc protecting group necessitating the development of a new strategy for deprotection of this complexant class. A serendipitous result facilitated utilization of 3-methoxypropylamine as a mild deprotecting agent for various N-Boc protected heteroarenes via a proposed addition-elimination mechanism. Method development, application to various heteroarenes including indoles, 1,2-indazoles, 1,2-pyrazoles, and related derivatives, a ten-fold scale-up reaction, and exptl. evaluation of a preliminary mechanistic hypothesis are reported herein.

Although many compounds look similar to this compound(651780-02-8)SDS of cas: 651780-02-8, numerous studies have shown that this compound(SMILES:CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts