So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Xingjie; Xia, Aiyou; Chen, Haoyi; Liu, Yuanhong researched the compound: Pyridine-3,5-dicarbonitrile( cas:1195-58-0 ).Synthetic Route of C7H3N3.They published the article 《General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP》 about this compound( cas:1195-58-0 ) in Organic Letters. Keywords: aryl halide zinc cyanide nickel DMAP; cyanoarene preparation; heteroaryl halide zinc cyanide nickel DMAP; cyanoheteroarene preparation; nickel cyanation catalyst; DMAP cyanation mediator. We’ll tell you more about this compound (cas:1195-58-0).
A new and general nickel-catalyzed cyanation of hetero(aryl) chlorides using less toxic Zn(CN)2 as the cyanide source has been developed. The reaction relies on the use of inexpensive NiCl2·6H2O/dppf/Zn as the catalytic system and DMAP as the additive, allowing the cyanation to occur under mild reaction conditions (50-80 °C) with wide functional group tolerance. DMAP was found to be crucial for successful transformation, and the reaction likely proceeds via a Ni(0)/Ni(II) catalysis based on mechanistic studies. The method was also successfully extended to aryl bromides and aryl iodides.
Although many compounds look similar to this compound(1195-58-0)Synthetic Route of C7H3N3, numerous studies have shown that this compound(SMILES:N#CC1=CC(C#N)=CN=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
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