Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 651780-02-8, is researched, Molecular C12H13BrN2O2, about Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions, the main research direction is indazole imidazopyrimidinyl thiazolyl imidazolothiazolyl imidazolyl preparation kinase inhibitor.Safety of tert-Butyl 5-bromo-1H-indazole-1-carboxylate.
The synthesis and biol. evaluation of 5-substituted indazoles as kinase inhibitors is reported. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicomponent reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for Gsk3β, Rock2, and Egfr.
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