The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one(SMILESS: O=C1N(C2=CC=C(Cl)C=C2)CCC1,cas:7661-33-8) is researched.Electric Literature of C10H14N2O. The article 《Interception of amide ylides with sulfonamides: synthesis of (E)-N-sulfonyl amidines catalyzed by Zn(OTf)2》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:7661-33-8).
An efficient method was reported for the synthesis of (E)-N-sulfonyl amidines such as I [R1 = H, Me, Ph, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Me, i-Pr, Ph, etc.; R1R3 = (CH2)2, (CH2)3; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH2)2, etc.; R4 = Ph, 4-MeC6H4, 2-naphthyl, etc.] in good yields with excellent stereoselectivity via Zn-catalyzed intermol. condensation reaction between sulfonamides and various amides. The wide substrate scope, exceptional functional group tolerance, operational simplicity and neutral reaction conditions made this mechanistically novel method well suited for preparing amidine compounds I.
Compounds in my other articles are similar to this one(1-(4-Chlorophenyl)pyrrolidin-2-one)HPLC of Formula: 7661-33-8, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts