Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about GDC-0449-A potent inhibitor of the hedgehog pathway.SDS of cas: 16588-26-4.
SAR for a wide variety of heterocyclic replacements for a benzimidazole led to the discovery of functionalized 2-pyridyl amides as novel inhibitors of the hedgehog pathway. The 2-pyridyl amides were optimized for potency, PK, and drug-like properties by modifications to the amide portion of the mol. resulting in I (GDC-0449). Amide I produced complete tumor regression at doses as low as 12.5 mg/kg BID in a medulloblastoma allograft mouse model that is wholly dependent on the Hh pathway for growth and is currently in human clin. trials, where it is initially being evaluated for the treatment of BCC.
Although many compounds look similar to this compound(16588-26-4)SDS of cas: 16588-26-4, numerous studies have shown that this compound(SMILES:BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts