So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ohkanda, Junko; Lockman, Jeffrey W.; Kothare, Mohit A.; Qian, Yimin; Blaskovich, Michelle A.; Sebti, Said M.; Hamilton, Andrew D. researched the compound: 3-Bromo-4-chloronitrobenzene( cas:16588-26-4 ).Safety of 3-Bromo-4-chloronitrobenzene.They published the article 《Design and Synthesis of Potent Nonpeptidic Farnesyltransferase Inhibitors Based on a Terphenyl Scaffold》 about this compound( cas:16588-26-4 ) in Journal of Medicinal Chemistry. Keywords: terphenylcarboxylate aminomercaptopropylamino imidazolylmethylamino preparation farnesyl transferase inhibitor. We’ll tell you more about this compound (cas:16588-26-4).
By modification of key carboxylate, hydrophobic, and zinc-binding groups projected from a sterically restricted terphenyl scaffold, a series of simple and nonpeptide mimetics of the Cys-Val-Ile-Met tetrapeptide substrate of protein farnesyltransferase (FTase) have been designed and synthesized. A crystal structure of 4-nitro-2-phenyl-3′-methoxycarbonylbiphenyl shows that the terphenyl fragment provides a large hydrophobic surface that potentially mimics the hydrophobic side chains of the three terminal residues in the tetrapeptide. 2-Phenyl-3-{N-[1-(4-cyanobenzyl)-1H-imidazol-5-yl]methyl}amino-3′-carboxylbiphenyl, in which the free thiol group was replaced with a 1-(4-cyanobenzyl)imidazole group, shows submicromolar inhibition activity against FTase in vitro and inhibits H-Ras processing in whole cells.
In some applications, this compound(16588-26-4)Safety of 3-Bromo-4-chloronitrobenzene is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
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