Safety of 3-Bromo-4-chloronitrobenzene. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Bromo-4-chloronitrobenzene, is researched, Molecular C6H3BrClNO2, CAS is 16588-26-4, about Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Author is Labadie, Sharada; Dragovich, Peter S.; Chen, Jinhua; Fauber, Benjamin P.; Boggs, Jason; Corson, Laura B.; Ding, Charles Z.; Eigenbrot, Charles; Ge, HongXiu; Ho, Qunh; Lai, Kwong Wah; Ma, Shuguang; Malek, Shiva; Peterson, David; Purkey, Hans E.; Robarge, Kirk; Salphati, Laurent; Sideris, Steven; Ultsch, Mark; VanderPorten, Erica; Wei, BinQing; Xu, Qing; Yen, Ivana; Yue, Qin; Zhang, Huihui; Zhang, Xuying; Zhou, Aihe.
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enone using structure-based design strategies resulted in inhibitors with considerable improvement in biochem. potency against human lactate dehydrogenase A (LDHA). These potent inhibitors were typically selective for LDHA over LDHB isoform (4-10 fold) and other structurally related malate dehydrogenases, MDH1 and MDH2 (>500 fold). An X-ray crystal structure of enzymically most potent mol. bound to LDHA revealed two addnl. interactions associated with enhanced biochem. potency.
In addition to the literature in the link below, there is a lot of literature about this compound(3-Bromo-4-chloronitrobenzene)Safety of 3-Bromo-4-chloronitrobenzene, illustrating the importance and wide applicability of this compound(16588-26-4).
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