Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 651780-02-8, is researched, Molecular C12H13BrN2O2, about Indazoles: Regioselective Protection and Subsequent Amine Coupling Reactions, the main research direction is indazole regioselective protection Buchwald amine coupling.Application of 651780-02-8.
Indazoles are unselectively protected under strongly basic conditions to give a mixture at positions N-1 and N-2. Under mildly acidic conditions, regioselective protection at N-2 takes place. Thermodn. conditions lead to regioselective protection at N-1. This trend applies to various substituted indazoles. Protected 5-bromoindazoles participate in Buchwald reactions with a range of amines to generate novel derivatives
In addition to the literature in the link below, there is a lot of literature about this compound(tert-Butyl 5-bromo-1H-indazole-1-carboxylate)Application of 651780-02-8, illustrating the importance and wide applicability of this compound(651780-02-8).
Reference:
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