Zheng, Yanling; Nie, Xufeng; Long, Yang; Ji, Li; Fu, Haiyan; Zheng, Xueli; Chen, Hua; Li, Ruixiang published the article 《Ruthenium-catalyzed synthesis of N-substituted lactams by acceptorless dehydrogenative coupling of diols with primary amines》. Keywords: lactam preparation green chem; diol amine dehydrogenative coupling ruthenium catalyst.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.
The first example of synthesis of N-substituted lactams I (R = Ph, 4-(propan-2-yl)phenyl, 2H-1,3-benzodioxol-5-yl, naphthalen-2-yl, etc.; n = 1,2,3) and N-(p-tolyl)isoindolin-2-one via an acceptorless dehydrogenative coupling of diols HO(CH2)2(CH2)nCH2OH and [2-(hydroxymethyl)phenyl]methanol with primary amines RNH2 in one step, which was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene-phosphine-phosphine ligand as the catalyst have been reported.
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