Tan, Bryan Yong-Hao; Teo, Yong-Chua published the article 《Mild and Efficient Cobalt-Catalyzed Cross-Coupling of Aliphatic Amides and Aryl Iodides in Water》. Keywords: aryl iodide aliphatic amide cross coupling cobalt catalyst water; arylamide flutamide preparation.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Related Products of 7661-33-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.
A convenient protocol for the C-N cross-coupling of aliphatic amides and iodobenzene is demonstrated using a simple and inexpensive Co(C2O4)·2H2O/N,N’-dimethylethylenediamine (DMEDA) catalytic system in water. Good yields of N-arylated products I [R1 = Pr, i-Pr, Bu, etc; R2 = Ph, 2-F-C6H4, 4-Me-C6H4, etc.] were isolated (up to 85%) and the protocol has been successfully applied to the synthesis of the anticancer drug, flutamide.
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