Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 438630-64-9, is researched, SMILESS is ClS(=O)(=O)C1=CNN=C1, Molecular C3H3ClN2O2SJournal, Organic Chemistry Frontiers called A robust and facile method for desulfonation to amines, Author is Li, Chen; Huang, Yilei; Cao, Sheng; Luo, Yunhao; Zhang, Ying; Yang, Guang, the main research direction is amine preparation; aromatic aliphatic sulfonamide desulfonation.Product Details of 438630-64-9.
In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chem. yields. Moreover, the functional groups tested were generally well tolerated.
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