Related Products of 7661-33-8. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Copper-catalyzed C-N coupling of amides and nitrogen-containing heterocycles in the presence of cesium fluoride. Author is Phillips, Dean P.; Zhu, Xue-Feng; Lau, Thomas L.; He, Xiaohui; Yang, Kunyong; Liu, Hong.
The copper-catalyzed C-N coupling of amides to aryl halides usually requires the use of strong alkali metal bases, such as K2CO3, K3PO4, and Cs2CO3, at high temperature We discovered that CsF is sufficiently basic to promote the cross-coupling of amides and carbamates with aryl halides. Most aryl iodides coupled in high yield at room temperature This alternative base may be a suitable replacement for substrates that are incompatible with high temperature and strongly basic conditions and can further enhance the chemoselectivity of this reaction.
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