The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ) is researched.Name: Dichloro(1,5-cyclooctadiene)platinum(II).Sayadi, Mohsen; Sabounchei, Seyyed Javad; Sedghi, Asieh; Bayat, Mehdi; Hosseinzadeh, Leila; Gable, Robert W. published the article 《Synthesis, characterization, theoretical and cytotoxicity studies of Pd(II) and Pt(II) complexes with new bidentate carbon donor ligand》 about this compound( cas:12080-32-9 ) in Polyhedron. Keywords: palladium platinum bidentate phosphorus ylide complex preparation DFT calculation; crystal structure bidentate phosphorus ylide ligand; fluorescence palladium platinum bidentate phosphorus ylide complex; antitumor activity palladium platinum bidentate phosphorus ylide complex. Let’s learn more about this compound (cas:12080-32-9).
The new phosphonium salt, the C,C-chelating phosphorus ylide ligand, (MeOC6H5C(O)CH:PPh2(CH2)2PPh2:CHC(O)C6H5OMe), and its Pd(II) and Pt(II) complexes were synthesized and the cytotoxic activity of the synthesized complexes against three human cancer cell lines, including HeLa (Human cervix cancer cell line), KB (human oral cancer cell line) and U87 MG (human glioblastoma cell line) were evaluated using an MTT assay. The new compounds were identified and characterized using multinuclear (1H, 13C and 31P) NMR, IR spectroscopy, elemental anal., and through UV absorption and fluorescence emission spectra. Also, the crystal structure of the phosphorus ylide ligand was determined by single-crystal x-ray diffraction anal. According to the obtained results from the MTT assay, the Pd(II) and Pt(II) complexes demonstrated a higher cytotoxic activity against KB human oral cancer cells in comparison with other cell lines, rendering these compounds into suitable candidates for further anti-oral cancer studies. Furthermore, a theor. study on structure and nature of the M-C bonding between the Y ligand (ylide) and MCl2 fragment in the [YMCl2] (M = Pd, Pt and Y = (MeOC6H5C(O)CH:PPh2(CH2)2PPh2:CHC(O)C6H5OMe)) complexes are reported via NBO and energy-decomposition anal. (EDA).
As far as I know, this compound(12080-32-9)Name: Dichloro(1,5-cyclooctadiene)platinum(II) can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
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