The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ) is researched.Category: alcohols-buliding-blocks.Gholivand, Khodayar; Maghsoud, Yazdan; Kahnouji, Mohammad; Hosseini, Mahdieh; Satari, Mohammad; Abdolmaleki, Parviz; Roe, Stephen Mark published the article 《Platinum(II) complexes containing hydrazide-based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents》 about this compound( cas:12080-32-9 ) in Applied Organometallic Chemistry. Keywords: DFT FMO platinum chloride diphenylphosphinoamino complex; antitumor activity platinum chloride diphenylphosphinoamino complex; crystal structure platinum chloride diphenylphosphinoamino complex preparation. Let’s learn more about this compound (cas:12080-32-9).
Four new N,N-bis(diphenylphosphino)amine ligands (amine = 1-amino-4-methylpiperazine (L1), N-aminophthalimide (L2), 4-aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using IR and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single-crystal x-ray diffraction techniques. The antitumor activities of the synthesized complexes determined using MTT assay on MDA-MB-231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose- and time-dependent manner (e.g. at a complex concentration of 100 μg ml-1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1-C4, resp.). Theor. approaches were also used to investigate the energy and the nature of metal-ligand and metal-chlorine interactions in the complexes, which could explain their biol. activities. The interaction between ligand and Pt is stronger in C2, while the Pt-Cl interaction is weaker in this complex in comparison with the other complexes.
As far as I know, this compound(12080-32-9)Category: alcohols-buliding-blocks can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
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