The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (5aS,10bR)-2-(2,6-Diethylphenyl)-4,5a,6,10b-tetrahydro-2H-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-11-ium tetrafluoroborate( cas:1787246-78-9 ) is researched.Category: alcohols-buliding-blocks.Hovey, M. Todd; Cohen, Daniel T.; Walden, Daniel M.; Cheong, Paul H.-Y.; Scheidt, Karl A. published the article 《A Carbene Catalysis Strategy for the Synthesis of Protoilludane Natural Products》 about this compound( cas:1787246-78-9 ) in Angewandte Chemie, International Edition. Keywords: carbene catalysis mellolide protoilludane marasmane sesquiterpenoid synthesis; N-heterocyclic carbenes; armillaridin; marasmane; protoilludane; total synthesis. Let’s learn more about this compound (cas:1787246-78-9).
The Armillaria and Lactarius genera of fungi produce the antimicrobial and cytotoxic mellolide, protoilludane, and marasmane sesquiterpenoids. We report a unified synthetic strategy to access the protoilludane, mellolide, and marasmane families of natural products. The key features of these syntheses are (1) the organocatalytic, enantioselective construction of key chiral intermediates from a simple achiral precursor, (2) the utility of a key 1,2-cyclobutanediol intermediate to serve as a precursor to each natural product class, and (3) a direct chem. conversion of a protoilludane to a marasmane (I → II) through serendipitous ring contraction, which provides exptl. support for their proposed biosynthetic relationships.
There is still a lot of research devoted to this compound(SMILES：CCC1=C(C(CC)=CC=C1)N2N=C3[N+]([C@]4([C@@]([H])(OC3)CC5=C4C=CC=C5)[H])=C2.F[B-](F)(F)F)Category: alcohols-buliding-blocks, and with the development of science, more effects of this compound(1787246-78-9) can be discovered.
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