Month: March 2022

Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Cyclization of ω-halo amides to lactams. Author is Manhas, Maghar S.; Jeng, Stella J..

N-Aryl-β-bromopropionamides and -γ-bromobutyramides, where the aryl group is Ph or 3 α-cholestanyl, are treated with Na in liquid NH3 to give 1 aryl-2-azetidionones (I) (Ar = Ph, o- and p-BrC6H4, etc.) and 1-aryl-2-pyrrolidinones. Lactams are also prepared from bromo amides and NaH in Me2SO and KOBu-tert in Me2SO.

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Safety of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one, is researched, Molecular C10H10ClNO, CAS is 7661-33-8, about Iridium(III)-catalyzed regioselective direct arylation of sp2 C-H bonds with diaryliodonium salts. Author is Gao, Pan; Liu, Li; Shi, Zhuangzhi; Yuan, Yu.

A regioselective direct arylation of arenes and olefins with aryliodonium salts at the ortho position to provide biaryl compounds, e.g., I was reported. The key to the high selectivity was the appropriate choice of aryliodonium salts as the arylating reagent in presence of a cationic iridium(III) catalyst. The coordination of the metal with an oxygen atom or a nitrogen atom and subsequent C-H activation allowed for direct arylation with coupling partners. This reaction proceeded under mild reaction conditions and with a high tolerance of various functional groups including many halide functional groups.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Organic Chemistry called Continuous Flow Nucleophilic Aromatic Substitution with Dimethylamine Generated in Situ by Decomposition of DMF, Author is Petersen, Trine P.; Larsen, Anders F.; Ritzen, Andreas; Ulven, Trond, which mentions a compound: 16588-26-4, SMILESS is BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl, Molecular C6H3BrClNO2, Formula: C6H3BrClNO2.

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis, characterization, and photophysical properties of cyclometalated N-Heterocyclic carbene Platinum(II) complexes, published in 2019-02-01, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, SDS of cas: 12080-32-9.

Cyclometalated platinum complexes I (R = Me, 3-thienylmethyl; X1, X2 = H, benzo) were prepared by a two-step, one-pot procedure and characterized; the complexes showed photoluminescence at 450-550 nm. Thiophene and benzothiophene ligands containing N-heterocyclic carbene (NHC) moieties were used to synthesize five and six-membered Pt(II) metallacycles. Ligand scaffolding was synthesized using two methods. The ligands were synthesized using a coupling reaction, utilizing Cu2O as the catalyst or were synthesized using a nucleophilic substitution reaction. The ligands were then metalated by chelate-assisted C-H activation. The synthesis, characterization, reactivity, and photophys. properties of these NHC-functionalized, cyclometalated products are reported.

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Application In Synthesis of tert-Butyl 5-bromo-1H-indazole-1-carboxylate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate, is researched, Molecular C12H13BrN2O2, CAS is 651780-02-8, about Scaffold oriented synthesis. Part 4: Design, synthesis and biological evaluation of novel 5-substituted indazoles as potent and selective kinase inhibitors employing heterocycle forming and multicomponent reactions. Author is Akritopoulou-Zanze, Irini; Wakefield, Brian D.; Gasiecki, Alan; Kalvin, Douglas; Johnson, Eric F.; Kovar, Peter; Djuric, Stevan W..

The synthesis and biol. evaluation of 5-substituted indazoles as kinase inhibitors is reported. The compounds were synthesized in a parallel synthesis fashion from readily available starting materials employing heterocycle forming and multicomponent reactions and were evaluated against a panel of kinase assays. Potent inhibitors were identified for Gsk3β, Rock2, and Egfr.

There is still a lot of research devoted to this compound(SMILES：CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12)Application In Synthesis of tert-Butyl 5-bromo-1H-indazole-1-carboxylate, and with the development of science, more effects of this compound(651780-02-8) can be discovered.

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The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Nuclear-substituted derivatives of 4,4′-diaminodiphenyl sulfone》. Authors are Berg, S. S..The article about the compound:3-Bromo-4-chloronitrobenzenecas:16588-26-4,SMILESS:BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl).Quality Control of 3-Bromo-4-chloronitrobenzene. Through the article, more information about this compound (cas:16588-26-4) is conveyed.

The therapeutic effect of (4-H3NC6H4)3SO3 prompted the investigation of the halogen derivatives; these were tested orally in vivo against Staphylococcus aureus and Streptococcus pyogenes in mice; a decrease in toxicity in the order Cl < Br < iodine, together with corresponding decrease in activity, was observed 2,4-Br(O2N)C6H3NH2 (18.5 g.), through the diazo reaction, gives 12.5 g. 1-chloro-2-bromo-4-nitrobenzene, b0.1 100°, m. 61°. p-O2NC6H4SH (1.55 g.) and 0.4 g. NaOH in 20 cc. EtOH, added to 1.9 g. 3,4-Cl2C6H3NO2 in 10 cc. EtOH and refluxed 2 h., give 1.3 g. 2-chloro-4,4'-dinitrodiphenyl sulfide (I), yellow, m. 144°; the 2-Br analog, yellow, m. 159°, and the 2-I analog, yellow, m. 168°. 3,4-Cl2C6H3NO2 (15 g.) in 60 cc. EtOH, treated (5 min.) with 10 g. Na2S.9H2O in 40 cc. 25% aqueous EtOH and refluxed 6 h., gives 7.2 g. [2,4-Cl(O2N)C6H3]2S, yellow, m. 163°; the portion (3 g.) insoluble in 95% AcOH is the compound C24H12O5N4Cl4S2, probably RN(→O):NR, where R = 3,4-Cl[2,4-Cl(O2N)C6H3S]C6H3S-, red, m. 195°. 2,2'-Diiodo-4,4'-dinitrodiphenyl sulfide (II), pale red, m. 186°. 2,4-Br(O2N)C6H3OH yields an acetate (III), pale yellow, m. 86°; 13 g. III, 7.8 g. p-O2NC6H4SH, 3 g. K2CO3, and 100 cc. Me2CO, refluxed 2 h., yield 6 g. 4,4'-dinitro-2-acetoxydiphenyl sulfide (IV), yellow, m. 100°. Dropwise addition of 7.5 g. KMnO4 in 50 cc. hot H2O to 10 g. I in 150 cc. boiling AcOH gives 8 g. 2-chloro-4,4'-dinitrodiphenyl sulfone (V), m. 182-3°; 2-Br analog, m. 162°, 2-I analog, pale yellow, m. 165°; the sulfone from II, yellow, m. 260°. IV yields 4,4'-dinitro-2-hydroxydiphenyl disulfone, yellow, m. 216°. Reduced Fe (10 g.), added slowly to 5 g. V in 200 cc. boiling AcOH and the mixture heated 10 min. at 90°, gives 3 g. 2-chloro-4,4'-diaminodiphenyl sulfone, pale yellow, m. 114°; 2-Br analog, yellow, m. 157°; 2-I analog, buff, m. 207°. 2,2'-Dichloro-4,4'-diaminodiphenyl sulfone, orange, m. 263°; 2,2'-di-I analog, m. 280°. 4,4'-Diamino-2-hydroxydiphenyl sulfone, m. 134-5° [sulfate, m. 208° (decomposition)] (cf. Burton and Hoggarth, C.A. 39, 4854.7). There is still a lot of research devoted to this compound(SMILES：BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl)Quality Control of 3-Bromo-4-chloronitrobenzene, and with the development of science, more effects of this compound(16588-26-4) can be discovered.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ji, Radhe Shyam; Raghuvanshi, Abhinav; Jha, Badrinath; Mathur, Pradeep researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Synthetic Route of C8H12Cl2Pt.They published the article 《Reactions of [Ru6(μ6–C)(C6H5CH3)(CO)14]: Synthesis of some new Ru-Pt carbonyl clusters and diphosphine substitution》 about this compound( cas:12080-32-9 ) in Journal of Organometallic Chemistry. Keywords: carbido ruthenium carbonyl cluster reaction platinum diphosphine; crystal mol structure carbido ruthenium carbonyl platinum diphosphine complex. We’ll tell you more about this compound (cas:12080-32-9).

Three new RuPt clusters [Ru6Pt(μ6-C)(C6H5CH3)(CO)13(COD)] (2), [Ru6Pt(μ6-C)(C6H5CH3)(CO)14(PPh3)] (3) and [Ru6Pt2(μ6-C)(C6H5CH3)(CO)13(PPh3)3] (4) were obtained from the reaction of [Ru6(μ6-C)(C6H5CH3)(CO)14] (1) with two different Pt precursors. Both 2 and 3 consists of a Ru6Pt cluster with face capped octahedron metal core, whereas, 4 has a unique Ru6Pt2 cluster core structure with doubly capped octahedron. Further, CO substitution behavior of 1 was studied with diphosphine ligands, which results in the formation of mono and bi substituted products, which also show the removal of the toluene cap by the dppe ligand. All the compounds were characterized structurally by x-ray diffraction anal.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called In Situ Synthesized Silica-Supported Co@N-Doped Carbon as Highly Efficient and Reusable Catalysts for Selective Reduction of Halogenated Nitroaromatics, published in 2020-09-15, which mentions a compound: 16588-26-4, Name is 3-Bromo-4-chloronitrobenzene, Molecular C6H3BrClNO2, Recommanded Product: 3-Bromo-4-chloronitrobenzene.

Silica-supported Co@N-doped carbon (Co@CN/SiO2) catalysts were first prepared by a one-step impregnation with a mixed solution of cobalt nitrate, glucose and urea, followed by in situ carbonization and reduction The Co@CN/SiO2 catalysts were investigated for the selective reduction of nitro aromatics RNO2 (R = Ph, 4,5-dichloro-2-nitroaniline, 2-chloro-3-nitropyridine, etc.) to the corresponding anilines RNH2 using hydrazine hydrate. The Co@CN/SiO2-500 carbonized at 500°C exhibited the highest catalytic activity and excellent stability without any decay of activity after 6 cycles for the reduction of nitrobenzene. Both metallic Co atoms and Co-N species formed in the Co@CN/SiO2 catalysts were active, but the Co-N species were dominant active sites. The high activities of the Co@CN/SiO2 catalysts were attributed to the synergistic effect between the Co and N atoms, promoting heterolytic cleavage of hydrazine to form H+/H- pairs. Representative examples demonstrated that the Co@CN/SiO2-500 could completely transform various halogen-substituted nitro aromatics to the corresponding halogenated anilines with high TOFs and selectivity of >99.5%.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 3-Bromo-4-chloronitrobenzene(SMILESS: BrC1=C(C=CC(=C1)[N+](=O)[O-])Cl,cas:16588-26-4) is researched.Application In Synthesis of 2-Bromomethyl-1,3-dioxolane. The article 《Structurally Simple Inhibitors of Lanosterol 14α-Demethylase Are Efficacious In a Rodent Model of Acute Chagas Disease》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:16588-26-4).

We report structure-activity studies of a large number of dialkyl imidazoles as inhibitors of Trypanosoma cruzi lanosterol-14α-demethylase (L14DM). The compounds have a simple structure compared to posaconazole, another L14DM inhibitor that is an anti-Chagas drug candidate. Several compounds display potency for killing T. cruzi amastigotes in vitro with values of EC50 in the 0.4-10 nM range. Two compounds were selected for efficacy studies in a mouse model of acute Chagas disease. At oral doses of 20-50 mg/kg given after establishment of parasite infection, the compounds reduced parasitemia in the blood to undetectable levels, and anal. of remaining parasites by PCR revealed a lack of parasites in the majority of animals. These dialkyl imidazoles are substantially less expensive to produce than posaconazole and are appropriate for further development toward an anti-Chagas disease clin. candidate.

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Tosolini, Massimo; Avo, Joao; Parola, Antonio Jorge; Balducci, Gabriele; Tecilla, Paolo published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Safety of Dichloro(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

A new sterically encumbered sym. substituted 4,5-bis(diphenylphosphino)acenaphthene ligand (L) has been prepared The ligand readily forms distorted square-planar complexes with group 10 metal ions [Ni(II), Pd(II), Pt(II)] and a dimeric tetrahedral complex with Cu(I). The x-ray structures of the ligand and of the complexes show a notably short distance between the two phosphorus atoms, well below than twice the van der Waals radius of P, due to the steric requirements of the rigid acenaphthene backbone. Moreover, in the complexes a stabilizing π-π interaction between two Ph rings belonging to the two P atoms is present. The [LCuCl]2 complex is weakly fluorescent both in solution and in the solid state with higher quantum yield as a solid where it exhibits thermally-activated delayed fluorescence and phosphorescence. [LPdCl2] and [LCuCl]2 behave as chloride transporters across a liposomal phospholipid membrane with the Pd(II) complex displaying a very high activity.

If you want to learn more about this compound(Dichloro(1,5-cyclooctadiene)platinum(II))Safety of Dichloro(1,5-cyclooctadiene)platinum(II), you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(12080-32-9).

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