Month: March 2022

Related Products of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

Was synthesized following the same general procedure as that for the preparation of 4-ethoxybenzyl chloride; thionyl chloride (7.42 g, 69.2 mmol), 4-butoxybenzyl alcohol (9.45 g, 52.4 mmol), CH2Cl2 (145 mL). Oil, 10.4 g (99%). 1H NMR (300 MHz, CDCl3) delta=7.28 (d, 2H, J=6.6 Hz), 6.86 (d, 2H, J=6.6 Hz), 4.56 (s, 2H), 3.95 (t, 2H, J=6.6 Hz), 1.76 (m, 2H), 1.48 (m, 2H), 0.97 (t, 3H, J=7.5 Hz). 13C NMR (75 MHz, CDCl3) delta=159.5, 130.2, 129.7, 114.9, 67.9, 46.6, 31.5, 19.4, 14.0.

Statistics shows that 6214-45-5 is playing an increasingly important role. we look forward to future research findings about (4-Butoxyphenyl)methanol.

Reference:
Patent; Percec, Virgil; US2006/88499; (2006); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1875-89-4, name is 2-(m-Tolyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C9H12O

3-methyl phenethyl alcohol (5 g, 36.7 MMOL) was diluted in 30 mL of chloroform and ammonium nitrate (3.12 g, 38.9 MMOL) was added. The reaction mixture was cooled to 0 °C and trifluor acetic acid anhydride (16.02 mL, 113 MMOL) was added dropwise. The reaction stirred at 0 °C for 3 hours before water was added to slowly quench the reaction. The chloroform layer was washed with water then collected and dried over NA2SO4 then concentrated. The desired isomer crystallized out of the crude solution in ethyl acetate and was then triturated with acetonitrile to afford 5.25 g of the desired isomer as a brown solid. Yield 87percent; MS (APCI) : 199 [M-H]-.

With the rapid development of chemical substances, we look forward to future research findings about 1875-89-4.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/41793; (2004); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81335-87-7, name is (2-Amino-4-methylphenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.18, as common compound, the synthetic route is as follows.SDS of cas: 81335-87-7

General procedure: To a solution of 1a (1.2 g, 7.61 mmol) in CH2Cl2 (20 mL) was added MnO2 (2.6 g, 30.1 mmol) and stirred at rt under an Ar atmosphere. After 23 h with stirring, the reaction mixture was filtrated and evaporated. The residue was crystallized from AcOEt to give 7a (1.0 g, 85%) as a yellow needle crystal.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,81335-87-7, (2-Amino-4-methylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Article; Ida, Yoshihiro; Matsubara, Ayaka; Nemoto, Toru; Saito, Manabu; Hirayama, Shigeto; Fujii, Hideaki; Nagase, Hiroshi; Bioorganic and Medicinal Chemistry; vol. 20; 19; (2012); p. 5810 – 5831;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 94687-10-2, name is Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C20H24O7

£’rytftro-l-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)-l,3-propanediol (2g): (0178) (0179) 2g (0180) Scheme 8. Synthesis of i?? i zro-l-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)-l,3- propanediol (2g). This compound was prepared according to a literature procedure. (Buendia, J. ; (0181) Mottweiler, J.; Bolm, C. Chem. Eur. J. 2011, 17, 13877.) Spectral data were consistent with those reported in the literature. *H NMR (400 MHz, CDC13) delta 7.07 (ddd, J = 8.2 Hz, 7.2, 1.6, 1.6 Hz, 1H), 7.02-6.84 (M, 5H), 6.82 (D, J = 8.2 Hz, 1H), 4.98 (b t, J = 4.8 Hz, 1 H), 4.16 (ddd, J = 6.0, 4.8, 3.5 Hz, 1 H), 3.95-3.90 (m, 1H), 3.87 (s, 3H), 3.86 (s, 6H), 3.66 (ddd, J = 12.0, 7.2, 3.5 Hz, 1H), 2.87 ppm (b s, 1H). HRMS (EI) calculated for C18H2206Na [M + Na]+ 357.1314, found 357.1311.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 94687-10-2, Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate.

Reference:
Patent; WISCONSIN ALUMNI RESEARCH FOUNDATION; STAHL, Shannon, S.; COON, Joshua; RAHIMI, Alireza; ULBRICH, Arne; WO2015/138563; (2015); A1;,
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Synthetic Route of 813-99-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 813-99-0, name is 3-Chloro-2,2-bis(chloromethyl)propan-1-ol, molecular formula is C5H9Cl3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The product from the previous step (0.66 g, 1.25 mmol) was dissolved in dichloromethane (30 mL). Then 3-chloro-2,2-di(chloromethyl)propane-1-ol(0.24 g, 1.25 mmol) and DMAP (catalytic amount) were added. The reactantswere cooled to 0 C. EDAC (0.24 g, 1.25 mmol) was then added. The reactant was stirred at room temperature for 24h, and distilled under reduced pressure. The residue was purified by silica gel column chromatography (gradient elutionwith eluent: N-hexane/ethyl acetate) to give 3-chloro-2,2-di(chloromethyl)propyl 4-(2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-2,6-dimethyl-phenoxy] butyl)-4-oxo-2-acetamino-butyrate (0.57 g, yield 65%).

According to the analysis of related databases, 813-99-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd; Shanghai Synergy Pharmaceutical Sciences Co., Ltd; GE, Jian; LI, Yunfei; ZHANG, Zhen; WANG, Yijin; WANG, Jiamiao; CHENG, Tao; (57 pag.)EP3348548; (2018); A1;,
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Adding a certain compound to certain chemical reactions, such as: 103694-68-4, 2,2-Dimethyl-3-(m-tolyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2,2-Dimethyl-3-(m-tolyl)propan-1-ol, blongs to alcohols-buliding-blocks compound. name: 2,2-Dimethyl-3-(m-tolyl)propan-1-ol

EXAMPLE 6 Manufacture of 1-methoxy-2,2-dimethyl-3-(3-methylphenyl)-propane In a 250 ml three-necked flask flushed with argon, 4.5 g of 2,2-dimethyl-3-(3-methylphenyl)-propan-1-ol (according to Example 5) in 50 ml of dry tetrahydrofuran were boiled for 11/2 hours under reflux with 0.7 g of sodium hydride. 3.2 g of dimethyl sulfate in 30 ml of tetrahydrofuran were then added dropwise thereto and the mixture was boiled under reflux for a further hour. After leaving the reaction mixture to stand for 24 hours, it was extracted by shaking with 20 ml of 10% by weight sodium hydroxide solution. Finally, the organic phase was dried with potassium carbonate and subjected to fractional distillation. 3.6 g of end product were obtained at 52 C./0.12 mbar.

The synthetic route of 103694-68-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Consortium fur Elektrochemische Industrie GmbH; US4710316; (1987); A;,
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Related Products of 54410-90-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54410-90-1, name is 4-Pentylcyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

(R)-4-(6-Hydroxnaphthalen-2-yl)-4-methyl-oxazolidin-2-one (Example 4, 0.3303 g, 0.001358 mol) was added to a capped 40 mL vial equipped with a magnetic stir bar. 4-o Pentyl-cyclohexanol (0.277 g, 0.00163 mol) was added, followed by tetrahydrofuran (6.00 mL, 0.0740 mol). Triphenylphosphine polymer-bound (1.17 g, 0.00217 mol) was then added and the mixture was stirred for 5 minutes. Diisopropyl azodicarboxylate (0.428 mL, 0.00217 mol) was then added and the mixture was stirred for 48 hours at room temperature. The mixture was diluted in ethyl acetate, filtered through CELITE, concentrated unders vacuum and purified by flash chromatography (0-5% MeOH in dichloromethane) to give 0.3672 g of the title compound (68% yield).

According to the analysis of related databases, 54410-90-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN IDEC MA INC.; GUCKIAN, Kevin, M.; CALDWELL, Richard, D.; KUMARAVEL, Gnanasambandam; LEE, Wen-cherng; LIN, Edward, Yin-shiang; LIU, Xiaogao; MA, Bin; SCOTT, Daniel, M.; SHI, Zhan; ZHENG, Guo, Zhu; TAVERAS, Arthur, G.; THOMAS, Jermaine; WO2010/51030; (2010); A1;,
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Application of 155310-11-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, molecular formula is C3H7F2NO, molecular weight is 111.0906, as common compound, the synthetic route is as follows.

50 mL of THF was added to 50 mL of aqueous solution of the compound 41, and then reacted with 1.13 g (1.0 eq., 5.17 mmol) of Boc2O at 0 C. It was then stirred overnight. After confirming by TLC the disappearance of the reacting materials, THF was removed by using an evaporator. The residual liquid was added with ethyl acetate, and liquid fractionation extraction was performed 3 times. The collected organic layer was washed with a saturated aqueous solution of NaCl. After drying over magnesium sulfate, it was concentrated under reduced pressure by using an evaporator in water bath at 40 C. As a result, the solids are obtained, which were then washed with hexane to obtain 1.08 g of the desired compound 42 (2 step yield of 99% from the compound 18). 1H-NMR signal assignment is given in the following. 1H-NMR (500 MHz, CDCl3) delta1.46 (9H, s), 3.54 (2H, ddd), 3.67 (2H, ddd), 3.95 (1H, m), 4.98 (1H, br).

The chemical industry reduces the impact on the environment during synthesis 155310-11-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Seikagaku Corporation; Miyamoto, Kenji; Yasuda, Yosuke; Takeuchi, Hisayuki; Yoshioka, Keiji; (69 pag.)US2016/151506; (2016); A1;,
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Synthetic Route of 6214-45-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6214-45-5, name is (4-Butoxyphenyl)methanol, molecular formula is C11H16O2, molecular weight is 180.24, as common compound, the synthetic route is as follows.

To a mixture of the compound of Example 58 (200 mg, 1.0 mmol) and pyridine (177 mul, 2.2 mmol) in anhydrous acetonitrile (3 ml), at 0 C. and under nitrogen, was added diphosgene (132 mul, 1.1 mmol). The mixture was allowed to warm to room temperature and stirred for 10 min, before addition to (4-butoxyphenyl)methanol (198 mg, 1.1 mmol) via syringe. The reaction mixture was stirred at room temperature for 30 min and filtered.The filtrate was purified by automated preparative liquid chromatography (Gilson system, 150 mm×22.4 mm LUNA C18(2) 10 mum column, 24 ml/min) using an acetonitrile:water gradient [15:85 (3 min) to 98:2 (16 min)]. The appropriate fractions were combined and concentrated to give the title compound (6 mg).Experimental MH+ 364.0; expected 363.2 (compound de-carboxylates)1H-NMR (d6-Acetone): 0.92-0.98 (3H), 1.43-1.55 (5H), 1.69-1.78 (2H), 2.24-2.30 (6H), 3.97-4.01 (2H), 5.04-5.09 (1H), 5.17-5.18 (2H), 6.48-6.50 (1H), 6.83-6.88 (3H), 6.95-6.98 (2H), 7.10-7.13 (2H), 7.44-7.45 (1H)Rhip. Funct. ED100 mg/cm2=0.03

The chemical industry reduces the impact on the environment during synthesis 6214-45-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; US2007/167506; (2007); A1;,
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Related Products of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.

[0332j A solution of 7-bromochroman-4-ol (200 mg, 0.88 mmol, 1.0 equiv) in toluene (5 mL) was cooled in an ice bath under N2 and treated with DPPA (532 mg, 1.93 mmol, 2.2 equiv) in one portion followed by DBU (293 mg, 1.93 mmol, 2.2 equiv). The reaction temperature was kept at 0 C for 1 h and then was warmed to room temperature for 16 h. The mixture was diluted with EtOAc (50 mL), washed with 2N HC1 (2 x 30 mL), brine and the organic layer was dried over Na2504, filtered then concentrated. The crude product was purified by silica gel column (eluted with PE). 4-azido-7-bromochroman (188 mg, yield: 90%) was obtained as a white solid. ?H NMR (400 MHz, CDC13) 5: 7.07-7.06 (m, 3H), 4.56 (t, J= 3.6 Hz, 1H), 4.30-4.17 (m, 2H), 2.19-1.99 (m, 2H).

According to the analysis of related databases, 18385-82-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; HOPKINS, Brian, T.; MA, Bin; CHAN, Timothy, Raymond; SUN, Lihong; ZHANG, Lei; KUMARAVEL, Gnanasambandam; LYSSIKATOS, Joseph, P.; KOCH, Kevin; MIAO, Hua; WO2015/89337; (2015); A1;,
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