Month: March 2022

Application of 123206-83-7, Adding some certain compound to certain chemical reactions, such as: 123206-83-7, name is 4-(2-Bromophenyl)butan-1-ol,molecular formula is C10H13BrO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 123206-83-7.

Step C: To a solution of 4-(o-bromophenyl)-1-butanol (1.222 g, ca 0.0053 mol) and tetrakis(triphenylphosphine) palladium (0) (650 mg, 0.562 mmol) in 1,2-dimethoxyethane (55 mL) was added thiophene-2-boronic acid (2.057 g, 0.016 mol) and 1 N aqueous NaHCO3 (15 mL). The resulting mixture was heated at reflux under nitrogen atmosphere for 3 days. The dark reaction mixture was diluted with water (50 mL) and extracted with EtOAc (100 mL). The organic layer was dried over Na2SO4, filtered through a bed of Celite and concentrated to yield a crude which was purified by flash chromatography (30% EtOAc in hexane) to yield 4-(2-thien-2-yl-phenyl)-butan-1-ol as a light brown oil. 1H NMR (300 MHz, DMSO d6) delta ??1.37-1.56 (m, 4H), 2.66-2.71 (m, 2H), 3.31-3.35 (m, 2H), 4.33 (br s, 1 H), 7.10-7.15 (m, 2H), 7.21-7.26 (m, 1 H), 7.31-7.34 (m, 3H), 7.59-7.61 (m, 1 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 123206-83-7, 4-(2-Bromophenyl)butan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Janssen Pharmaceuticals, Inc.; JORDAN, Alfonzo; PAN, Kevin; REITZ, Allen, B.; (71 pag.)EP1392687; (2017); B1;,
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Electric Literature of 92409-15-9 ,Some common heterocyclic compound, 92409-15-9, molecular formula is C17H20O5, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: The catalytic hydrogenolysis of lignin model compounds was performedusing a 50 mL Zr-alloy autoclave provided by Anhui KemiMachinery Technology Co., Ltd. For a typical procedure, lignin modelcompounds (0.5 mmol or 1 mmol) or organosolv lignin (35 mg), heterogeneousFe catalyst (100 mg), and solvent (20 mL) were added intothe autoclave with a quartz lining. After purging the reactor with H2,the reaction was conducted with 1 MPa H2 (at room temperature) at240 C for 12 h with a stirring speed of 800 rpm. After reaction, internalstandards are added to the product solution, and then the liquid productswere analyzed by using both GC and GC-MS. For the conversionof alpha-O-4 lignin model compound, 2-phenylethanol is used as internalstandard to determine the yields of benzyl alcohol and phenol, anddodecane is used to determine the yield of toluene. For the conversionof beta-O-4 lignin model compounds, benzyl alcohol and dodecane areused as internal standards to determine the yields of phenolic fragmentsand aromatic fragments, respectively. A representative GC spectrumcan be seen in Fig. S11 in supporting information. GC-MS analyses wereperformed on an Agilent 7890 Gas Chromatograph equipped with a DBWAXETR30m×0.25 mm×0.25mm capillary column (Agilent) or aHP-5MS 30m×0.25 mm×0.25mm capillary column (Agilent).Although HP-5MS column is unsuitable for the determination of productsyields due to the low polarity, it can be used to confirm whethersome complex lignin model compounds were completely converted.The GC was directly interfaced to an Agilent 5977 mass selective detector(EI, 70 eV). The following GC oven temperature programs wereused: 40 C hold for 1 min, ramp 5 C min-1 to a temperature of 120 C,and then ramp 10 C min-1 to 300 C and hold for 5 min. To get the representative GC spectrum of gaseous products, the gaseous phase wascollected and injected into a Fuli 9790II Gas Chromatograph equippedwith a TDX-01 packed column and a thermal conductivity detector(TCD) through a six-way valve to analyze the composition.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,92409-15-9, its application will become more common.

Reference:
Article; Li, Jiang; Sun, Hui; Liu, Jia-xing; Zhang, Jun-jie; Li, Zhen-xing; Fu, Yao; Molecular catalysis; vol. 452; (2018); p. 36 – 45;,
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Reference of 666747-06-4, Adding some certain compound to certain chemical reactions, such as: 666747-06-4, name is (2,4-Dibromophenyl)methanol,molecular formula is C7H6Br2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 666747-06-4.

Step 2:Synthesis of 2,4-dibromo-1-(1-methoxy-1-methylethoxymethyl)benzeneUnder a nitrogen atmosphere, to a solution of 2,4-dibromobenzyl alcohol (40 g, 0.15 mol) in tetrahydrofuran (300 ml) was added 2-methoxypropene (144 ml, 1.5 mol) at room temperature, and then the mixture was cooled to 0°C.At the same temperature, pyridinium p-toluenesulfonic acid (75 mg, 0.30 mmol) was added and the mixture was stirred for 1 hour.The reaction mixture was poured into a saturated aqueous solution of sodium hydrogen carbonate cooled to 0°C, and extracted with toluene.The organic layer was washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the titled compound as an oil in quantitative yield.The product was used in the next step without further purification.1H-NMR (CDCl3) delta: 1.44 (6H, s), 3.22 (3H, s), 4.48 (2H, s), 7.42 (1H, d, J=8.0Hz), 7.44 (1H, dd, J=1.5, 8.0Hz), 7.68 (1H, d, J=1.5Hz).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 666747-06-4, (2,4-Dibromophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chugai Seiyaku Kabushiki Kaisha; EP2308886; (2011); A1;,
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Synthetic Route of 6214-45-5, Adding some certain compound to certain chemical reactions, such as: 6214-45-5, name is (4-Butoxyphenyl)methanol,molecular formula is C11H16O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6214-45-5.

To a solution of different benzyl alcohols (7.82 mmol) in acetonitrile (27 mL), chlorotrimethylsilane (8.73 mmol) was added and then sodium iodide (8.05 mmol) was slowly added. This mixture was allowed to reflux with constant stirring at 90 C for 2 h, under nitrogen.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6214-45-5, (4-Butoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lopez, Jhon J.; Perez, Edwin G.; Synthetic Communications; vol. 49; 5; (2019); p. 715 – 723;,
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Related Products of 41570-61-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 41570-61-0, name is 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol, molecular formula is C12H18ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 1, 1.8 g (7.9 mmol), was dissolved in 30 mL of diethyl ether, 0.9 mL (7.9 mmol) of a 8.5 M solution of HCl in propan-2-ol was added, and the precipitate was filtered off, washed with diethyl ether, and dried over phosphoric anhydride. Yield 1.9 g (91%), white crystals, mp 165-167C. 1H NMR spectrum (DMSO-d6), delta, ppm: 1.31 s (9H, t-Bu), 2.70 d (1H, CH2, J = 12.3 Hz), 3.07 d (1H,CH2, J = 12.4 Hz), 5.31 d (1H, CH, J = 10.1 Hz), 6.37 s(1H, OH), 7.37 d.d (1H, Harom, J = 7.3, 1.5 Hz), 7.41-7.49 m (2H, Harom), 7.69 d (1H, Harom, J = 8.8 Hz),8.64 br.s (1H, NH), 9.20 br.s (1H, NH). 13C NMR spectrum(DMSO-d6), deltaC, ppm: 25.4 [(CH3)3C], 47.1[C(CH3)3], 57.0 (CH2), 66.3 (CHOH), 128.0 (C4?, C5?),128.5 (C3?), 129.7 (C6?), 131.4 (C2?), 139.5 (C1?). Lowresolutionmass spectrum: m/z: 228.23 [M + H]+. Highresolutionmass spectrum: m/z 228.11490 [M + H]+.Mass spectrum (EI), m/z: 141 [M – CH2=NHC(CH3)3]+,86 [CH2=NHC(CH3)3]+.f

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 41570-61-0, 2-(tert-Butylamino)-1-(2-chlorophenyl)ethanol.

Reference:
Article; Burdeinyi, M. L.; Glushkova, M. A.; Popkov, S. V.; Russian Journal of Organic Chemistry; vol. 56; 3; (2020); p. 390 – 394; Zh. Org. Khim.; vol. 56; 3; (2020); p. 379 – 383,5;,
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Application of 18385-82-5, Adding some certain compound to certain chemical reactions, such as: 18385-82-5, name is 7-Bromochroman-4-ol,molecular formula is C9H9BrO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18385-82-5.

To a solution of 7-Bromochroman-4-ol (Prepared as described in U52013/18055)(0.64g, 2.78 mmol), tert-Butyl 4-(2-hydroxy-5-(trifluoromethyl)phenyl)piperidine- 1 -carboxylate (Intermediate-iS) (0.80g, 2.3 16 mmol) and triphenylphosphine (0.91g, 3.47 mmol) in THF (25 ml) was added DIAD (0.901 ml, 4.63 mmol) stined at room temperature for 16h. Reaction mixture was diluted with ethyl actate and washed with aqueous NaOH solution, brine, dried over Na2SO4 and evaporated. The crude product was purified by flash column chromatography( 10% ethyl acetate/Petroleum ether) to obtain title compound(0.5g, 39 %). LCMS(ESI):m/z 578.12 (M+Na).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 18385-82-5, 7-Bromochroman-4-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LUPIN LIMITED; RAMDAS, Vidya; LORIYA, Rajeshkumar, Maganlal; WALKE, Deepak, Sahebrao; DAS, Amit, Kumar; KHAN, Talha, Hussain; BANERJEE, Moloy; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; (187 pag.)WO2015/151001; (2015); A1;,
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Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6Br2O, blongs to alcohols-buliding-blocks compound. Formula: C7H6Br2O

To a stirred solution of commercially available 2,4-dibromobenzyl alcohol SI-i(500 mg, 1.88 mmol) in DMF (4 mL), under inert atmosphere, were added imidazole(153 mg, 2.25 mmol, i.2 eq.) and TBSC1 (340 mg, 2.25 mmol, 1.2 eq.). The resultingmixture was stirred for 12 h, then hydrolyzed with water and extracted with a mixture9:1 cyclohexane/CH2C12 (three times). The combined organic extracts were washed withwater, brine, dried over Mg504, filtered and concentrated under reduced pressure. The cmde product was then purified by chromatography (100percent petroleum ether) to afford the title compound SI-2 (638 mg, 1.68 mmol, 89percent) as a colorless oil.?H NMR (CDC13, 300 MHz): 7.66 (d, J = 1.8 Hz, 1H), 7.49-7.42 (m, 2H), 4.67 (s, 2H), 0.97 (s, 9H), 0.14 (s, 6H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,666747-06-4, (2,4-Dibromophenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE DE BORDEAUX; UNIVERSITE DE RENNES 1; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; WODRICH, Harald; CHEVET, Eric; VAN DE WEGHE, Pierre; (73 pag.)WO2018/178167; (2018); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 666747-06-4, (2,4-Dibromophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (2,4-Dibromophenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (2,4-Dibromophenyl)methanol

To the solution of (2,4-dibromophenyl)methanol (10.0 g, 37.6 mmol) was added TBSC1 (6.8 g, 45.1 mmol), imidazole (5.1 g, 75.2 mmol). The mixture was stirred at 40 °C overnight. After the reaction completed, the mixture was washed by water and DCM was removed under vacuo. The residue was purified by column chromatography on silica gel by elution with petroleum ether : ethyl acetate =50: 1 to give tert-butyl(2,4-dibromobenzyloxy)dimethylsilane (14 g, yield 98percent) as a light yellow liquid. XH NMR (400 MHz, CDC13) delta 7.68 (d, 1 H), 7.47 (m, 2H), 4.69 (s, 2H), 0.94 (s, 9 H), 0.15 (s, 6 H).

The synthetic route of 666747-06-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; BILL AND MELINDA GATES FOUNDATION; LI, Xianfeng; LUNDE, Christopher, S.; JACOBS, Robert, T.; HERNANDEZ, Vincent, S.; XIA, Yi; PLATTNER, Jacob, J.; CAO, Kathy, Jingyuan; ZHANG, Yong-kang; Perry, Matthew; (268 pag.)WO2017/151489; (2017); A1;,
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Related Products of 2576-29-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2576-29-6, name is 2-((2-Chloroethyl)amino)ethanol hydrochloride, molecular formula is C4H11Cl2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Similarly, a suspension of 2-[(2-chloroethyl)amino]ethanol hydrochloride (2.0 g, 8.4 mmol) in 1,4-dioxane (150 mL) was treated with Et3N (1.8 g), cooled with ice bath and then 15 (2.0 g,5.4 mmol) was added. The reaction was kept at 20 0C overnight, then water (100 mL) was added and the mixture was extracted with EtOAc (3×150 mL). The combined organic phases were washed with pre-cooled dilute HCl, water, aqueous NaHCO3, and brine, dried and concentrated under pressure, and then passed through a short column of silica gel, eluting with heptane/EtOAc (1:1), to give 16a (4.1 g, 37%).

According to the analysis of related databases, 2576-29-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AUCKLAND UNISERVICES LIMITED; WO2008/30112; (2008); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.54410-90-1, name is 4-Pentylcyclohexanol, molecular formula is C11H22O, molecular weight is 170.2918, as common compound, the synthetic route is as follows.SDS of cas: 54410-90-1

EXAMPLE 11 Preparation of 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester 2.10 g of 6-ethyl-trans-decalin-2-carboxylic acid, prepared according to Example 5, are dissolved in 30 ml of absolute methylene chloride and treated with a solution 1.87 g of 4-pentyl-trans-cyclohexanol in 20 ml of absolute methylene chloride. Subsequently, there are added 0.20 g of 4-(dimethylamino)pyridine and, after cooling to 5 C., while stirring 2.48 g of solid dicyclohexylcarbodiimide. Dicyclohexylurea begins to separate out after a short time. After 1 hour at 2 C. and 1.25 hours at room temperature, the precipitate is removed by filtration under suction and back-washed with methylene chloride and hexane. By evaporating the filtrate in vacuo, there are obtained 4.80 g of crude 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester which, for purification, is chromatographed on 90 g of silica gel. Elution with hexane/toluene (1:1) yields 3.22 g of substance which is recrystallized from hexane up to constant melting point and clearing point and dried up to constant weight in a high vacuum (0.01 mbar). There is obtained 6-ethyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester as colorless crystals; m.p. 50.4 C., cl.p. 86.3 C. The following compound can be prepared in an analogous manner: 6-Butyl-trans-decalin-2-carboxylic acid trans-4-pentyl-1-cyclohexyl ester; m.p. 62.2-65.4 C.; cl.p. 109.3 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,54410-90-1, 4-Pentylcyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; Hoffmann-La Roche Inc.; US4391731; (1983); A;,
Alcohol – Wikipedia,
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