Month: March 2022

Application of 205877-13-0 ,Some common heterocyclic compound, 205877-13-0, molecular formula is C8H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A solution of 4-toluene sulfonyl chloride (4.58 g, 1.2 equiv) or methanesulfonyl chloride (1.9 mL, 1.2 equiv) and pyridine (2 mL, 1.3 equiv) in 20 mL CH2Cl2 was added slowly to the solution of compound 11 (0.02 mol) in 40 mL CH2Cl2. The mixture was stirred overnight at room temperature. Then 30 mL diluted HCl solution was added to the reaction mixture, the organic layer was separated using separating funnel. Subequently, the aqueous phase was extracted with 15 mL CH2Cl2 three times, the combined organic layers were washed separately with saturated NaHCO3 (30 mL) and saturated NaCl (30 mL) three times. The organic layer was dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using petroleum ether/EtOAc = 1/1 to give the product 12.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,205877-13-0, its application will become more common.

Reference:
Article; Xu, Changrui; Wu, Zhengxing; Chen, Jianzhong; Xie, Fang; Zhang, Wanbin; Tetrahedron; vol. 73; 14; (2017); p. 1904 – 1910;,
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Reference of 81156-68-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.81156-68-5, name is 2,4-Dichlorophenethyl alcohol, molecular formula is C8H8Cl2O, molecular weight is 191.06, as common compound, the synthetic route is as follows.

(ii) 3-[2-(2,4-Dichlorophenyl)-Ethoxy]-4,5-Dimethoxy-Benzoic Acid 2 g (9.42 mmol) of 3-Hydroxy-4,5-dimethoxy-benzoic acid methyl ester was dissolved in 100 ml of anhydrous tetrahydrofuran. To this solution was added 1.98 g (10.37 mmol) of 2-(2,4-Dichlorophenyl)-ethanol, 9.415 g (equivalent to 28.27 mmol PPh3) of triphenylphosphine derivatized polystyrene and 4.924 g (28.27 mmol) of DEAD. The solution was shaken for 16 h at RT. The polymer was filtered off and washed with ethyl acetate. The solvent was removed under reduced pressure. The residue was taken-up in ethyl acetate and the solution was washed three times with water and twice with saturated aqueous sodium chloride. The organic phase was dried with magnesium sulphate, filtered and the solvent was removed under reduced pressure. The residue was dissolved in 20 ml of dioxan. 1 ml of water was added to the solution followed by 2N aqueous NaOH to give a pH of 13. The reaction solution was heated at 60 C. for 10 hours. The solution was cooled to 0 C., 5 ml water was added, followed by concentrated hydrochloric acid to give a pH of 1 to 2, whereupon the product precipitated from solution. The product was filtered off and dried under reduced pressure.

The chemical industry reduces the impact on the environment during synthesis 81156-68-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1013031-65-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1013031-65-6 as follows.

To a solution of (2,6-dibromophenyl)methanol (5 g, 18.8 mmol) in dichloromethane (50 mL) was added te^butylchlorodimethylsilane (4.25 g, 28.2 mmol) and lH-imidazole (1.91 g, 28.2 mmol) at 0 C. The reaction was stirred at ambient temperature for 16 h. Upon completion, the mixture was washed with water (3 x 100 mL), the organic layer was dried over Na2S04. The organic layer was filtered and concentrated to dryness. Purification by column chromatography (PE) gave the product (7 g, yield: 95%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1013031-65-6, its application will become more common.

Reference:
Patent; SUNOVION PHARMACEUTICALS INC.; BOWEN, Carrie, A.; BURDI, Douglas, F.; HEFFERNAN, Michele, L., R.; HERMAN, Lee, W.; XIE, Linghong; (266 pag.)WO2019/28165; (2019); A1;,
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Reference of 92409-15-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 92409-15-9, name is 2-(2-Methoxyphenoxy)-1-(4-methoxyphenyl)propane-1,3-diol, molecular formula is C17H20O5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The 152 mg type g shown in lignin of beta – O – 4 model compound, 8 mg double rhodium catalyst, 80 mg NaOH added 1 ml distilled water, under protection of argon 110 C reaction 18 hours, to complete the lignin complete degradation, wherein the degradation product to the methoxy acetophenone of yield is 24%, P-acetone to yield 34%, O-methoxyphenol of yield is 62%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 92409-15-9, 2-(2-Methoxyphenoxy)-1-(4-methoxyphenyl)propane-1,3-diol.

Reference:
Patent; Shaanxi Normal University; Dalian Institute of Chemical Physics; Wang Chao; Liu Yuxuan; Li Changzhi; Xiao Jianliang; Wang Aiqin; Zhang Tao; Li Junjun; Xue Dong; Tang Weijun; (9 pag.)CN107253904; (2017); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 666747-06-4, name is (2,4-Dibromophenyl)methanol, molecular formula is C7H6Br2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of (2,4-Dibromophenyl)methanol

Zinc cyanide (1.01 g, 8.65 mmol) and tetrakis(triphenylphosphine) palladium (Pd(PPh3)4, 0.50 g, 0.43 mmol) were added into a solution of 2,4-dibromobenzyl alcohol (1-1, 2.3 g, 8.65 mmol) in DMF (20 mL). After deoxygenated via argon bubbling, the reaction mixture was heated at 80 °C and reacted for 5 hours, cooled down to room temperature, diluted with ethyl acetate (80 mL), washed successively with water (80 mLx3) and saturated brine (80 mLx3), dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated to obtain a crude product. The crude product was then purified by column chromatography (elution system: petroleum ether: ethyl acetate = 15/1-4/1) to obtain a white solid product (0.81 g, 44percent yield). The molecular ion peak shown by liquid chromatography-mass spectrometry was: MS (ESI): m/z 211.9/213.9 [M+H]+. NMR: 1HNMR (400 MHz, CDCl3) delta: 7.82 (s, 1 H), 7.69 (d, J = 8.0 Hz, 1 H), 7.65 (d, J = 8.0 Hz, 1 H), 4.80 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 666747-06-4.

Reference:
Patent; SUZHOU CONNECT BIOPHARMACEUTICALS, LTD.; ZHENG, Wei; PAN, Wubin; YANG, Xin; (47 pag.)EP3048103; (2016); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. A new synthetic method of this compound is introduced below., SDS of cas: 81335-87-7

General procedure: A test tube (25 mL) wascharged with 2-aminobenzyl alcohol 1 (0.5 mmol, 1equiv), alkynes 2 (0.75 mmol, 1.5 equiv), AgOTf (0.025 mmol, 5 mol %), HOTf (0.05mmol, 10 mol%), LiBr (0.05 mmol, 10mol%), H2O (0.2 mL), and toluene (3 mL) were added. Themixture was stirred at 40 oC in air for 8 hours, the reaction wascooled down to room temperature, the mixture was quenched by sat. aq. NaHCO3,and diluted with 10 mL dichloromethane and washed with 10 mL H2O.The aqueous layer was extracted twice with dichloromethane (10 mL) and thecombined organic phase was dried over Na2SO4. Afterevaporation of the solvents, the residue was purified by silica gelchromatography (hexane/AcOEt = 30:1).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Xu, Xuefeng; Zhang, Xu; Liu, Wenming; Zhao, Qiang; Wang, Zhiqiang; Yu, Lintao; Shi, Fu; Tetrahedron Letters; vol. 56; 24; (2015); p. 3790 – 3792;,
Alcohol – Wikipedia,
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Reference of 81335-87-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 81335-87-7, name is (2-Amino-4-methylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Benzyl alcohol derivative 11 (1 eq.) was dissolved in CH2Cl2 (0.4 M). Manganese (IV) oxide (2.1 eq.)was added under argon and the solution was left to stir at room temperature for 48 h. The progress ofthe reaction was monitored by TLC analysis. After completion, manganese oxide was filtered off andthe resulting filtrate was concentrated under reduced pressure. The crude product was purified by silicacolumn chromatography employing mixtures of n-hexane and ethyl acetate as eluents to obtain thedesired product 10.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 81335-87-7, (2-Amino-4-methylphenyl)methanol.

Reference:
Article; Jarrige, Lucie; Merad, Jeremy; Zaied, Siwar; Blanchard, Florent; Masson, Geraldine; Synlett; vol. 28; 14; (2017); p. 1724 – 1728;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 155310-11-5, name is 3-Amino-2,2-difluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 3-Amino-2,2-difluoropropan-1-ol

EXAMPLE 28; Preparation of Compound 79; Step 1 & Step 2; Into the solution of 2,2-difluoro-3-aminopropionic acid (2 g, 14.4 mmol) in 40 mL of THF, was added 2N LAH solution in THF at 0 C. The mixture was heated to reflux for 3 h. After cooling to 0 C., 1.75 mL of 5N KOH water solution was added and the mixture was filtered. The solid was washed with 40 ml of THF. The combined filtrates were dried with MgSO4. After removal of the solvent in vacuo, 525 mg of the desired compound 73 was obtained.To the crude compound 73 in 100 mL of toluene, was added TEA (552 mg, 5.46 mmol) and phthalic anhydrite (740 mg, 5 mmol). After azeotroping for 3 h, the toluene was removed in vacuo and the residue was purified by preparative flash chromatography (silica gel, ethyl acetate/hexane, 1:4) to afford the desired product 74 (358 mg): 1H NMR (CDCl3); 7.92 (2H, m), 7.8 (2H, m), 4.21(2H, t), 3.74 (2H, m) 3.23(1H, br; OH) MS [M+H]=241.89

The synthetic route of 155310-11-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Gilead Sciences, Inc.; US2010/22508; (2010); A1;,
Alcohol – Wikipedia,
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Application of 1051899-73-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1051899-73-0, name is (3-Amino-2-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2,4-dichloropyrimidine (300 mg, 2.01 mmol), (3-amino-2- fluorophenyl)methanol (256 mg, 1.81 mmol) and triethylamine (309 mul, 2.22 mmol) in 2- propanol (5 ml) was stirred over a period of 15 hrs at 90C as described in Method 1. Work-up and purification gave (3-(2-chloropyrimidin-4-ylamino)-2 -fluorophenyl) methanol (206 mg, 40.3 %) as a white solid. Mass Spectrum: M+H+ 254. NMR Spectrum (DMSOdbeta): 4.44 (s, 2H), 5.39 (bs, IH), 6.51 (bs, IH), 7.13 (ddd, IH), 7.30 (dd, IH), 7.36 (dd, IH), 8.09 (d, IH), 9.41 (bs, IH)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1051899-73-0, (3-Amino-2-fluorophenyl)methanol.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/104754; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 81156-68-5 ,Some common heterocyclic compound, 81156-68-5, molecular formula is C8H8Cl2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

5-[2-(2,4-Dichloro-phenyl)-ethoxy]-isophthalic acid dimethyl ester 1.75 g of triphenylphosphine and 1 g of 5-Hydroxy-isophthalic acid dimethyl ester were dissolved in 17 ml of anhydrous THF. The solution was cooled to 0-10 C. and a solution of 1 ml DEAD in 1 ml anhydrous THF was added dropwise over 20 min. The reaction was warmed to RT and stirred for 45 min. A solution of 11.3 ml 2-(2,4-Dichlorophenyl)-ethanol in 1 ml anhydrous THF was added with cooling. The reaction was stirred at RT for 16 h, then the solvents were removed under reduced pressure. The residue was treated with n-hepane:ethyl acetate/1:1. The filtrate was dried under reduced pressure and the product was purified by silica gel chromatography, eluding with n-heptane:ethyl acetate/4:1 to n-heptane:ethyl acetate/3:1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,81156-68-5, its application will become more common.

Reference:
Patent; Nazare, Marc; Will, David William; Peyman, Anuschirwan; Matter, Hans; Zoller, Gerhard; Gerlach, Uwe; US2002/198195; (2002); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts