Month: March 2022

Electric Literature of C8H12Cl2Pt. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Synthesis and catalytic performance of highly dispersed platinum nanoparticles supported on alumina via supercritical fluid deposition. Author is Jiang, Haoxi; Yao, Chuanxu; Wang, Yaodong; Zhang, Minhua.

Highly dispersed platinum nanoparticles (NPs) supported on alumina were prepared by supercritical fluid deposition (SFD) with the aid of co-solvent ethanol using inorganometallic Na2PtCl6·6H2O as Pt precursor. The mean Pt particle size (1.5 nm) was obtained at the optimized deposition conditions of 40°C and 110 bar and 3 h of deposition time. The catalysts were characterized by high-resolution transmission electron microscopy (HR-TEM), X-ray diffraction (XRD), CO diffuse reflectance IR Fourier transform spectroscopy (CO-DRIFTS), XPS, inductively coupled plasma optical emission spectrometry (ICP-OES) and hydrogen-oxygen titrations to investigate the structure-activity relationship. Compared with the catalyst prepared via an impregnation method, the Pt was highly dispersed to smaller particles for Pt/Al2O3 catalysts prepared by SFD and showed much higher catalytic activity of catalytic reforming of cyclohexane dehydrogenation.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-(4-Chlorophenyl)pyrrolidin-2-one(SMILESS: O=C1N(C2=CC=C(Cl)C=C2)CCC1,cas:7661-33-8) is researched.Name: (S)-5-(Hydroxymethyl)dihydrofuran-2(3H)-one. The article 《Amidation of Aryl Chlorides Using a Microwave-Assisted, Copper-Catalyzed Concurrent Tandem Catalytic Methodology》 in relation to this compound, is published in Organometallics. Let’s take a look at the latest research on this compound (cas:7661-33-8).

A copper iodide-catalyzed concurrent tandem catalytic (CTC) methodol. has been developed for the amidation of aryl chlorides where the aryl chloride is first converted to an aryl iodide via halogen exchange and the aryl iodide is subsequently transformed into the N-aryl secondary or tertiary amide. A variety of aryl chlorides were converted to aryl amides in up to 85% isolated yield using 20 mol% CuI, 60 mol% N,N’-cyclohexane-1,2-diamine, 2.2 equiv of K2CO3, and 1.05-1.5 equiv of amide in acetonitrile at 200° after 0.75-1 h. The same copper/ligand system served as multifunctional catalyst for both steps of the concurrent catalytic process with iodide present in substoichiometric amounts Mechanistic studies are consistent with CTC amidation occurring via a nonradical mechanism. Kinetic modeling was conducted to investigate the effect of competitive direct amidation of an aryl chloride or aryl bromide on the formation of product over time during a CTC amidation reaction.

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HPLC of Formula: 12080-32-9. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about pH-mediated colorimetric and luminescent sensing of aqueous nitrate anions by a platinum(II) luminophore@mesoporous silica composite. Author is Norton, Amie E.; Sharma, Malvika; Cashen, Christina; Dourges, Marie-Anne; Toupance, Thierry; Krause, Jeanette A.; Motkuri, Radha Kishan; Connick, William B.; Chatterjee, Sayandev.

Increased levels of nitrate (NO3-) in the environment can be detrimental to human health. Herein, we report a robust, cost-effective, and scalable, hybrid material-based colorimetric/luminescent sensor technol. for rapid, selective, sensitive, and interference-free in situ NO3- detection. These hybrid materials are based on a square-planar platinum(II) salt [Pt(tpy)Cl]PF6 (tpy = 2,2′;6′,2′′-terpyridine) supported on mesoporous silica. The platinum salt undergoes a vivid change in color and luminescence upon exposure to aqueous NO3- anions at pH ≤ 0 caused by substitution of the PF6- anions by aqueous NO3-. This change in photophysics of the platinum salt is induced by a rearrangement of its crystal lattice that leads to an extended Pt···Pt···Pt interaction, along with a concomitant change in its electronic structure. Furthermore, incorporating the material into mesoporous silica enhances the surface area and increases the detection sensitivity. A NO3- detection limit of 0.05 mM (3.1 ppm) is achieved, which is sufficiently lower than the ambient water quality limit of 0.16 mM (10 ppm) set by the United States Environmental Protection Agency. The colorimetric/luminescence of the hybrid material is highly selective to aqueous NO3- anions in the presence of other interfering anions, suggesting that this material is a promising candidate for the rapid NO3- detection and quantification in practical samples without separation, concentration, or other pretreatment steps.

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Application of 651780-02-8. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate, is researched, Molecular C12H13BrN2O2, CAS is 651780-02-8, about Accelerated Zincations for an Efficient and Mild Functionalization of Aromatics and Heterocycles. Author is Unsinn, Andreas; Wunderlich, Stefan H.; Knochel, Paul.

An improved process for the preparation of aromatic and heteroaromatic diorganozinc reagents and their subsequent reaction with electrophiles is presented. The new method, featuring the use of a 2,2,6,6-tetramethylpiperidyl (TMP) magnesium base in the presence of zinc chloride, is superior to the previous methods, which require the preparation of zinc bases. Specifically, the shorter reaction times under mild conditions provide an easier and more practical process, while the use of only a slight excess of the amide allows the isolation of products in high yields. These improvements are particularly significant for the large-scale preparation of organozincs and their subsequent reactions. Remarkably, beside the high kinetic activity, a wide range of functional groups is tolerated and sensitive heteroaromatics can easily be converted into the corresponding organometallic reagents and reacted with various electrophiles.

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Kukalenko, S. S.; Gracheva, N. A. published the article 《New synthesis of N-aryl- and N-alkylpyrrolidones, and some of their properties》. Keywords: aryl pyrrolidinones.They researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Reference of 1-(4-Chlorophenyl)pyrrolidin-2-one. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:7661-33-8) here.

N-Aryl pyrrolidinones (I) [R = 2,3-Me2C6H3, 2-ClC6H4, 4-ClC6H4, 3,4-Cl2C6H3, 4-BrC6H4, and 2,4-(MeO)BrC6H3] were prepared with 85-98% yield by heating equimolar amounts of γ-butyrolactone (II) and hydrochlorides of primary aromatic amines at 60-210° for 4-20 hr. The reaction of II with hydrochlorides of aliphatic amines proceeds with difficulty and the yield of the corresponding N-alkyl pyrrolidinones is 20-33%. All the pyrrolidinones are active fungicides.

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HPLC of Formula: 12080-32-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Multifunctional Pt(II)-Based Metallo-Supramolecular Polymer with Carboxylic Acid Groups: Electrochemical, Mechanochemical, Humidity, and pH Response. Author is Chakraborty, Chanchal; Rana, Utpal; Moriyama, Satoshi; Higuchi, Masayoshi.

We report multifunctional Pt(II)-based metallo-supramol. polymer with carboxylic acid groups (polyPtC). The polymer showed multi-stimuli-responsive emission to electrochem. redox, mech. force, humidity, and pH. It also exhibited humidity-responsive ionic conductivity Furthermore, it displayed electrofluorochromism. The emission switching between the two transition states (3MLCT/3LLCT and 3MMLCT) was based on the reversible changes of the interchain Pt-Pt interaction in polyPtC, which was caused by the secondary interaction or the crystalline-amorphous transition. The ionic conductivity of polyPtC was responsible for the humidity and the real-time humidity sensor with the polymer film was demonstrated on interdigitated Pt-electrodes. A solid-state electrochromic device with the polymer film was successfully fabricated to show reversible yellow-to-black electrochromism. In addition, it was revealed by the electrofluorochromic study that the pristine 3MLCT/3LLCT emission was quenched in the electrochem. reduced state (the black state), because the radical anion species of the ligand (tpy·-) generated at the neg. potential caused the repulsion among the polymer chains, expanded the Pt-Pt distance, and prevented the emission.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl 5-bromo-1H-indazole-1-carboxylate(SMILESS: CC(C)(C)OC(=O)N1N=CC2=CC(Br)=CC=C12,cas:651780-02-8) is researched.Product Details of 12080-32-9. The article 《Discovery of inhibitors of plasminogen activator inhibitor-1: Structure-activity study of 5-nitro-2-phenoxybenzoic acid derivatives》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:651780-02-8).

Two novel series of 5-nitro-2-phenoxybenzoic acid derivatives are designed as potent PAI-1 inhibitors using hybridization and conformational restriction strategy in the tiplaxtinin and piperazine chemo types. The lead compounds 5a, 6c, and 6e exhibited potent PAI-1 inhibitory activity and favorable oral bioavailability in the rodents.

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Radhakrishna, Latchupatula; Kunchur, Harish S.; Namdeo, Pavan K.; Butcher, Ray J.; Balakrishna, Maravanji S. researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Product Details of 12080-32-9.They published the article 《New 1,2,3-triazole based bis- and trisphosphine ligands: synthesis, transition metal chemistry and catalytic studies》 about this compound( cas:12080-32-9 ) in Dalton Transactions. Keywords: crystal structure transition metal complex containing triazolebisphosphine triazoletrisphosphine ligand; mol structure transition metal complex containing triazolebisphosphine triazoletrisphosphine ligand; transition metal complex containing triazolebisphosphine ligand preparation Heck catalyst; Heck reaction aryl bromide alkene metal triazolephosphine catalyst. We’ll tell you more about this compound (cas:12080-32-9).

The syntheses and transition metal chem. of triazole-based bis- and tris-phosphines, 5-(diphenylphosphanyl)-1-(2-(diphenylphosphanyl)phenyl)-4-phenyl-1H-1,2,3-triazole (2), 5-(diphenylphosphanyl)-4-(2-(diphenylphosphanyl)phenyl)-1-phenyl-1H-1,2,3-triazole (5), 1,4-bis(2-(diphenylphosphanyl)phenyl)-1H-1,2,3-triazole (6) and 5-(diphenylphosphanyl)-1,4-bis(2-(diphenylphosphanyl)phenyl)-1H-1,2,3-triazole (7), are described. Bisphosphines 5 and 6 show versatile coordination behavior due to the presence of at least four donor atoms. The reactions of 5 and 6 with Group VI metal carbonyl derivatives are highly sensitive to the reaction conditions. Bisphosphine 5 upon treatment with [M(CO)4(piperidine)2] (M = Mo and W) yielded both P,P and P,N coordinated complexes [M(CO)4(5)] [M = Mo-κ2-P,N (8); W-κ2-P,N (9); Mo-κ2-P,P (10); W-κ2-P,P (11)], whereas 6 afforded only P,N coordinated complexes [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))CH}-κ2-P,N}Mo(CO)4] (12) and [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))CH}-κ2-P,N}W(CO)4] (13). The reactions of 5 with [M(COD)Cl2] (M = Pd and Pt) yielded κ2-P,P chelate complexes 14 and 15, resp., whereas the treatment of 6 with [Pd(COD)Cl2] at ambient temperature gave a rare fused six-membered PCP pincer complex [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))C}-κ3-P,C,P}PdCl] (16). Similar reactions of 6 with [NiCl2(DME)] and [Pt(COD)Cl2] in the presence of LiHMDS yielded [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))C}-κ3-P,C,P}NiCl] (17) and [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))C}-κ3-P,C,P}PtCl] (18), resp. The reaction between 6 and [M(COD)Cl]2 (M = Rh and Ir) produced cationic complexes [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))CH}-κ2-P,N}Rh(C8H12)]Cl (19) and [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))CH}-κ2-P,N}Ir(C8H12)]Cl (20), resp., whereas the reaction with [Rh(acac)(CO)2] resulted in a pincer complex [{o-Ph2P(C6H4){1,2,3-N3C(o-Ph2P(C6H4))C}-κ3-P,C,P}Rh(CO)] (21). The structures of most of the compounds were determined by single crystal x-ray analyses. The fused six-membered PCP Pd pincer complex 16 is an excellent catalyst for the Mizoroki-Heck coupling reaction.

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Category: alcohols-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Synthesis and structure of thienyl Fischer carbene complexes of PtII for application in alkyne hydrosilylation.

Transmetalation of Group 6 thienylene Fischer carbene complexes to Pt(II) precursors yielded new examples of neutral Pt(II) bisethoxycarbene complexes with either 2-thienyl (T) or 5-thieno[2,3-b]thienylene (TT) carbene substituents. The use of analogous aminocarbene group 6 precursors proceeded to give isomeric Pt(II) product mixtures where the resultant bisaminocarbene ligands displayed different orientations due to restricted rotation around the Pt-aminocarbene bond caused by the sterically demanding TT substituents. The well-defined Pt(II) ethoxycarbene complexes were screened as catalyst precursors in the benchmark hydrosilylation reaction employing phenylacetylene and triethylsilane substrates. Marked selectivity for the β-E isomer (E)-triethyl(styryl)silane was observed, and the (pre)catalysts proved recyclable, active in solvent-free reactions, and displaying a high alkyne functional group tolerance.

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Category: alcohols-buliding-blocks. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6-Bromo-5-iodopyridin-3-amine, is researched, Molecular C5H4BrIN2, CAS is 697300-68-8, about 5-Substituted Derivatives of 6-Halogeno-3-((2-(S)-azetidinyl)methoxy)pyridine and 6-Halogeno-3-((2-(S)-pyrrolidinyl)methoxy)pyridine with Low Picomolar Affinity for α4β2 Nicotinic Acetylcholine Receptor and Wide Range of Lipophilicity: Potential Probes for Imaging with Positron Emission Tomography.

Potential positron emission tomog. (PET) ligands with low picomolar affinity at the nicotinic acetylcholine receptor (nAChR) and with lipophilicity (log D) ranging from -1.6 to +1.5 have been synthesized. Most members of the series, which are derivatives of 5-substituted-6-halo-A-85380, exhibited a higher binding affinity at α4β2-nAChRs than epibatidine. An anal., by mol. modeling, revealed an important role of the orientation of the addnl. heterocyclic ring on the binding affinity of the ligands with nAChRs. The existing nicotinic pharmacophore models do not accommodate this finding. Two compounds of the series, 6-[18F]fluoro-5-(3-pyridinyl)-A-85380 (I) and 6-chloro-3-[[2-(S)-azetidinyl]methoxy]-5-[(2-[18F]fluoro-5-pyridinyl)pyridine], were radiolabeled with 18F. Comparison of PET data for [18F]-I and 2-[18F]FA shows the influence of lipophilicity on the binding potential. Recent PET studies with [18F]-I demonstrated that its binding potential values in Rhesus monkey brain were ca. 2.5 times those of 2-[18F]FA. Therefore, [18F]35 and several other members of the series, when radiolabeled, will be suitable for quant. imaging of extrathalamic nAChRs.

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