So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Prince, Robin J.; Gao, Fang; Pazienza, Jessica E.; Marx, Isaac E.; Schulz, Jurgen; Hopkins, Brian T. researched the compound: 1-(4-Chlorophenyl)pyrrolidin-2-one( cas:7661-33-8 ).Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one.They published the article 《Utilization of Cyclic Amides as Masked Aldehyde Equivalents in Reductive Amination Reactions》 about this compound( cas:7661-33-8 ) in Journal of Organic Chemistry. Keywords: cyclic amide masked aldehyde equivalent reductive amination. We’ll tell you more about this compound (cas:7661-33-8).
An operationally simple protocol has been discovered that couples primary or secondary amines with N-aryl-substituted lactams to deliver differentiated diamines in moderate to high yields. The process allows for the partial reduction of a lactam in the presence of Cp2ZrHCl (Schwartz’s reagent), followed by a reductive amination between the resulting hemiaminal and primary or secondary amine. These reactions can be telescoped in a one-pot fashion to significantly simplify the operation. The scope of amines and substituted lactams of various ring sizes was demonstrated through the formation of a range of differentiated diamine products. Furthermore, this methodol. was expanded to include N-aryl pyrrolidinone substrates with an enantiopure ester group at the 5-position, and α-amino piperidinones were prepared with complete retention of stereochem. information. The development of this chem. has enabled the consideration of lactams as useful synthons.
If you want to learn more about this compound(1-(4-Chlorophenyl)pyrrolidin-2-one)Quality Control of 1-(4-Chlorophenyl)pyrrolidin-2-one, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(7661-33-8).
Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts