Adding a certain compound to certain chemical reactions, such as: 222978-01-0, (4-Bromo-3-fluorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H6BrFO, blongs to alcohols-buliding-blocks compound. Computed Properties of C7H6BrFO
To a solution of (4-bromo-3-fluoro-phenyl)-methanol (410 mg, 2.0 mmol) and imidazole (163 mg, 2.4 mmol) in DMF (10 mL) was added triisopropylsilyl chloride (0.472 mL, 2.2 mmol). The reaction mixture was stirred at room temperature for 18 hours and then partitioned between ethyl acetate and water. The organic layer was isolated, washed with brine, dried (Na2SO4), filtered and concentrated in vacuo. The resultant residue was purified by flash chromatography (Si-SPE, pentane) to provide the title compound as a colourless oil (643 mg, 89%). IH NMR (CDCl3, 400MHz) 7.48 (dd, J=8.1, 7.0 Hz, IH), 7.16 (d, J = 9.7 Hz, IH), 6.99 (d, J=8.7 Hz, IH), 4.78 (s, 2H), 1.04-1.24 (m, 21H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,222978-01-0, (4-Bromo-3-fluorophenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; GENENTECH, INC.; WO2008/24725; (2008); A1;,
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